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Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action.
Francis SH, Corbin JD. Francis SH, et al. Crit Rev Clin Lab Sci. 1999 Aug;36(4):275-328. doi: 10.1080/10408369991239213. Crit Rev Clin Lab Sci. 1999. PMID: 10486703 Review.
Tyrosine-612 in PDE5 contributes to higher affinity for vardenafil over sildenafil.
Corbin J, Francis S, Zoraghi R. Corbin J, et al. Among authors: francis s. Int J Impot Res. 2006 May-Jun;18(3):251-7. doi: 10.1038/sj.ijir.3901411. Int J Impot Res. 2006. PMID: 16281046
PDE5 inhibitors: targeting erectile dysfunction in diabetics.
Francis SH, Corbin JD. Francis SH, et al. Curr Opin Pharmacol. 2011 Dec;11(6):683-8. doi: 10.1016/j.coph.2011.08.004. Epub 2011 Sep 15. Curr Opin Pharmacol. 2011. PMID: 21924956 Review.
Stimulation of serotonin transport by the cyclic GMP phosphodiesterase-5 inhibitor sildenafil.
Zhu CB, Hewlett WA, Francis SH, Corbin JD, Blakely RD. Zhu CB, et al. Among authors: francis sh. Eur J Pharmacol. 2004 Nov 3;504(1-2):1-6. doi: 10.1016/j.ejphar.2004.09.023. Eur J Pharmacol. 2004. PMID: 15507214
Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation.
Zoraghi R, Bessay EP, Corbin JD, Francis SH. Zoraghi R, et al. Among authors: francis sh. J Biol Chem. 2005 Mar 25;280(12):12051-63. doi: 10.1074/jbc.M413611200. Epub 2005 Jan 27. J Biol Chem. 2005. PMID: 15677448
cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake.
Steiner JA, Carneiro AM, Wright J, Matthies HJ, Prasad HC, Nicki CK, Dostmann WR, Buchanan CC, Corbin JD, Francis SH, Blakely RD. Steiner JA, et al. Among authors: francis sh. Mol Brain. 2009 Aug 5;2:26. doi: 10.1186/1756-6606-2-26. Mol Brain. 2009. PMID: 19656393 Free PMC article.
Cyclic GMP specifically suppresses Type-Ialpha cGMP-dependent protein kinase expression by ubiquitination.
Dey NB, Busch JL, Francis SH, Corbin JD, Lincoln TM. Dey NB, et al. Among authors: francis sh. Cell Signal. 2009 Jun;21(6):859-66. doi: 10.1016/j.cellsig.2009.01.014. Epub 2009 Jan 8. Cell Signal. 2009. PMID: 19168131 Free PMC article.
Mechanisms associated with cGMP binding and activation of cGMP-dependent protein kinase.
Wall ME, Francis SH, Corbin JD, Grimes K, Richie-Jannetta R, Kotera J, Macdonald BA, Gibson RR, Trewhella J. Wall ME, et al. Among authors: francis sh. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2380-5. doi: 10.1073/pnas.0534892100. Epub 2003 Feb 18. Proc Natl Acad Sci U S A. 2003. PMID: 12591946 Free PMC article.
cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5.
Kotera J, Grimes KA, Corbin JD, Francis SH. Kotera J, et al. Among authors: francis sh. Biochem J. 2003 Jun 1;372(Pt 2):419-26. doi: 10.1042/BJ20030107. Biochem J. 2003. PMID: 12617722 Free PMC article.
A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.
Blount MA, Zoraghi R, Ke H, Bessay EP, Corbin JD, Francis SH. Blount MA, et al. Among authors: francis sh. Mol Pharmacol. 2006 Nov;70(5):1822-31. doi: 10.1124/mol.106.028688. Epub 2006 Aug 22. Mol Pharmacol. 2006. PMID: 16926278
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