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Page 1
Restorative effects of (+)-epicatechin in a rodent model of aging induced muscle atrophy: underlying mechanisms.
Ramirez-Sanchez I, Navarrete-Yañez V, Ramirez L, Galera L, Mendez-Bolaina E, Najera V, Ceballos G, Villarreal F. Ramirez-Sanchez I, et al. Among authors: villarreal f. Food Funct. 2024 Apr 2;15(7):3669-3679. doi: 10.1039/d3fo04004f. Food Funct. 2024. PMID: 38487922
The objective of this study, was to characterize the capacity of the flavanol (+)-epicatechin (+Epi) to favorably modulate SkM mass and function in a rat model of aging induced sarcopenia and profile candidate mechanisms. ...
The objective of this study, was to characterize the capacity of the flavanol (+)-epicatechin (+Epi) to favorably modulate SkM mass a …
(-)-Epicatechin Is a Biased Ligand of Apelin Receptor.
Portilla-Martínez A, Ortiz-Flores MÁ, Meaney E, Villarreal F, Nájera N, Ceballos G. Portilla-Martínez A, et al. Among authors: villarreal f. Int J Mol Sci. 2022 Aug 11;23(16):8962. doi: 10.3390/ijms23168962. Int J Mol Sci. 2022. PMID: 36012227 Free PMC article.
(-)-Epicatechin (EC) is part of a large family of biomolecules called flavonoids and is widely distributed in the plant kingdom. ...
(-)-Epicatechin (EC) is part of a large family of biomolecules called flavonoids and is widely distributed in the plant kingdom. ...
Beneficial Effects of Flavonoids on Skeletal Muscle Health: A Systematic Review and Meta-Analysis.
Munguía L, Ortiz M, González C, Portilla A, Meaney E, Villarreal F, Nájera N, Ceballos G. Munguía L, et al. Among authors: villarreal f. J Med Food. 2022 May;25(5):465-486. doi: 10.1089/jmf.2021.0054. Epub 2022 Apr 8. J Med Food. 2022. PMID: 35394826 Review.
The following search terms were used: "flavonoids" OR "flavanols" OR "flavones" OR "anthocyanidins" OR "flavanones" OR "flavan-3-ols" OR "catechins" OR "epicatechin" OR "(-)-epicatechin" AND "skeletal muscle." The studies included in this review were preclinical stu …
The following search terms were used: "flavonoids" OR "flavanols" OR "flavones" OR "anthocyanidins" OR "flavanones" OR "flavan-3-ols" OR "ca …
Is it possible to treat nonalcoholic liver disease using a flavanol-based nutraceutical approach? Basic and clinical data.
Hidalgo I, Ortiz-Flores M, Villarreal F, Fonseca-Coronado S, Ceballos G, Meaney E, Nájera N. Hidalgo I, et al. Among authors: villarreal f. J Basic Clin Physiol Pharmacol. 2022 Feb 4;33(6):703-714. doi: 10.1515/jbcpp-2021-0285. eCollection 2022 Nov 1. J Basic Clin Physiol Pharmacol. 2022. PMID: 35119232 Review.
In this article, the beneficial effects of epigallocatechin-3-gallate (EGCG) and (-)-epicatechin (EC) are discussed. EGCG is the main catechin in green tea, which has shown in various studies its potential effect preventing and treating NAFLD since it has shown anti …
In this article, the beneficial effects of epigallocatechin-3-gallate (EGCG) and (-)-epicatechin (EC) are discussed. EGCG is the main …
(-)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy.
McDonald CM, Ramirez-Sanchez I, Oskarsson B, Joyce N, Aguilar C, Nicorici A, Dayan J, Goude E, Abresch RT, Villarreal F, Ceballos G, Perkins G, Dugar S, Schreiner G, Henricson EK. McDonald CM, et al. Among authors: villarreal f. Muscle Nerve. 2021 Feb;63(2):239-249. doi: 10.1002/mus.27108. Epub 2020 Dec 16. Muscle Nerve. 2021. PMID: 33125736 Free PMC article.
INTRODUCTION: We conducted an open-label study to examine the effects of the flavonoid (-)-epicatechin in seven ambulatory adult patients with Becker muscular dystrophy (BMD). METHODS: Seven participants received (-)-epicatechin 50 mg twice per day for 8 weeks. ...T …
INTRODUCTION: We conducted an open-label study to examine the effects of the flavonoid (-)-epicatechin in seven ambulatory adult pati …
Arginase inhibition by (-)-Epicatechin reverses endothelial cell aging.
Garate-Carrillo A, Navarrete-Yañez V, Ortiz-Vilchis P, Guevara G, Castillo C, Mendoza-Lorenzo P, Ceballos G, Ortiz-Flores M, Najera N, Bustamante-Pozo MM, Rubio-Gayosso I, Villarreal F, Ramirez-Sanchez I. Garate-Carrillo A, et al. Among authors: villarreal f. Eur J Pharmacol. 2020 Oct 15;885:173442. doi: 10.1016/j.ejphar.2020.173442. Epub 2020 Aug 11. Eur J Pharmacol. 2020. PMID: 32795514 Free PMC article.
The inhibition of Ar activity can reverse EnD and (-)-epicatechin (Epi) inhibits myocardial Ar activity. In this study, through in silico modeling we demonstrate that Epi interacts with Ar similarly to its inhibitor Norvaline (Norv). ...
The inhibition of Ar activity can reverse EnD and (-)-epicatechin (Epi) inhibits myocardial Ar activity. In this study, through in si …
(-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle.
Nogueira L, Ramirez-Sanchez I, Perkins GA, Murphy A, Taub PR, Ceballos G, Villarreal FJ, Hogan MC, Malek MH. Nogueira L, et al. Among authors: villarreal fj. J Physiol. 2011 Sep 15;589(Pt 18):4615-31. doi: 10.1113/jphysiol.2011.209924. Epub 2011 Jul 25. J Physiol. 2011. PMID: 21788351 Free PMC article.
The flavanol (-)-epicatechin, a component of cacao (cocoa), has been shown to have multiple health benefits in humans. ...Twenty-five male mice (C57BL/6N) were randomized into four groups: (1) water, (2) water-exercise (W-Ex), (3) (-)-epicatechin ((-)-Epi), and (4) …
The flavanol (-)-epicatechin, a component of cacao (cocoa), has been shown to have multiple health benefits in humans. ...Twenty-five …
Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy.
Tanabe K, Tamura Y, Lanaspa MA, Miyazaki M, Suzuki N, Sato W, Maeshima Y, Schreiner GF, Villarreal FJ, Johnson RJ, Nakagawa T. Tanabe K, et al. Among authors: villarreal fj. Am J Physiol Renal Physiol. 2012 Nov 1;303(9):F1264-74. doi: 10.1152/ajprenal.00227.2012. Epub 2012 Aug 29. Am J Physiol Renal Physiol. 2012. PMID: 22933302 Free PMC article.
Epicatechin was administered 8 h after cisplatin injury was induced in the mouse kidney. ...Such a protective effect of epicatechin might be attributed to decreased oxidative stress and reduced ERK activity. Finally, we confirmed that epicatechin did not pert …
Epicatechin was administered 8 h after cisplatin injury was induced in the mouse kidney. ...Such a protective effect of epicatechi …
Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation.
Gutierrez-Salmean G, Ciaraldi TP, Nogueira L, Barboza J, Taub PR, Hogan MC, Henry RR, Meaney E, Villarreal F, Ceballos G, Ramirez-Sanchez I. Gutierrez-Salmean G, et al. Among authors: villarreal f. J Nutr Biochem. 2014 Jan;25(1):91-4. doi: 10.1016/j.jnutbio.2013.09.007. Epub 2013 Oct 18. J Nutr Biochem. 2014. PMID: 24314870 Free PMC article.
Flavonoids are known for their healthy effects and limited toxicity. The flavanol (-)-epicatechin (Epi) enhances exercise capacity in mice, and Epi-rich cocoa improves skeletal muscle structure in heart failure patients. (-)-Epicatechin may thus hold promise as trea …
Flavonoids are known for their healthy effects and limited toxicity. The flavanol (-)-epicatechin (Epi) enhances exercise capacity in …
PXR is a target of (-)-epicatechin in skeletal muscle.
Ortiz-Flores M, Portilla-Martínez A, Cabrera-Pérez F, Nájera N, Meaney E, Villarreal F, Pérez-Durán J, Ceballos G. Ortiz-Flores M, et al. Among authors: villarreal f. Heliyon. 2020 Oct 30;6(10):e05357. doi: 10.1016/j.heliyon.2020.e05357. eCollection 2020 Oct. Heliyon. 2020. PMID: 33163657 Free PMC article.
(-)-Epicatechin (EC) is a flavanol that has shown numerous biological effects such as: decrease risk of cardiovascular dysfunction, metabolism regulation, skeletal muscle (SkM) performance improvement and SkM cells differentiation induction, among others. ...In order to de …
(-)-Epicatechin (EC) is a flavanol that has shown numerous biological effects such as: decrease risk of cardiovascular dysfunction, m …
55 results