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Page 1
Beneficial Effects of Flavonoids on Skeletal Muscle Health: A Systematic Review and Meta-Analysis.
Munguía L, Ortiz M, González C, Portilla A, Meaney E, Villarreal F, Nájera N, Ceballos G. Munguía L, et al. Among authors: villarreal f. J Med Food. 2022 May;25(5):465-486. doi: 10.1089/jmf.2021.0054. Epub 2022 Apr 8. J Med Food. 2022. PMID: 35394826
The following search terms were used: "flavonoids" OR "flavanols" OR "flavones" OR "anthocyanidins" OR "flavanones" OR "flavan-3-ols" OR "catechins" OR "epicatechin" OR "(-)-epicatechin" AND "skeletal muscle." The studies included in this review were preclinical stu …
The following search terms were used: "flavonoids" OR "flavanols" OR "flavones" OR "anthocyanidins" OR "flavanones" OR "flavan-3-ols" OR "ca …
(-)-Epicatechin Is a Biased Ligand of Apelin Receptor.
Portilla-Martínez A, Ortiz-Flores MÁ, Meaney E, Villarreal F, Nájera N, Ceballos G. Portilla-Martínez A, et al. Among authors: villarreal f. Int J Mol Sci. 2022 Aug 11;23(16):8962. doi: 10.3390/ijms23168962. Int J Mol Sci. 2022. PMID: 36012227 Free PMC article.
(-)-Epicatechin (EC) is part of a large family of biomolecules called flavonoids and is widely distributed in the plant kingdom. ...
(-)-Epicatechin (EC) is part of a large family of biomolecules called flavonoids and is widely distributed in the plant kingdom. ...
Enhancement of Statin Effects on Lipid Lowering and Reduction of Cardiovascular Risk Score by (-)-Epicatechin in Proof-of-Concept Pilot Study.
Ormiston CK, Pazargadi A, Rosander A, Ceballos G, Villarreal F, Taub PR. Ormiston CK, et al. Among authors: villarreal f. Clin Transl Sci. 2025 May;18(5):e70236. doi: 10.1111/cts.70236. Clin Transl Sci. 2025. PMID: 40387782 Free PMC article. Clinical Trial.
There remains an unmet need for strategies that improve statin tolerance and synergize their effect on atherogenic lipids. (-)-Epicatechin (Epi) is a natural flavonoid that can improve lipid biomarkers and mitochondrial function. ...
There remains an unmet need for strategies that improve statin tolerance and synergize their effect on atherogenic lipids. (-)-Epicatechi …
Is it possible to treat nonalcoholic liver disease using a flavanol-based nutraceutical approach? Basic and clinical data.
Hidalgo I, Ortiz-Flores M, Villarreal F, Fonseca-Coronado S, Ceballos G, Meaney E, Nájera N. Hidalgo I, et al. Among authors: villarreal f. J Basic Clin Physiol Pharmacol. 2022 Feb 4;33(6):703-714. doi: 10.1515/jbcpp-2021-0285. eCollection 2022 Nov 1. J Basic Clin Physiol Pharmacol. 2022. PMID: 35119232 Review.
In this article, the beneficial effects of epigallocatechin-3-gallate (EGCG) and (-)-epicatechin (EC) are discussed. EGCG is the main catechin in green tea, which has shown in various studies its potential effect preventing and treating NAFLD since it has shown anti …
In this article, the beneficial effects of epigallocatechin-3-gallate (EGCG) and (-)-epicatechin (EC) are discussed. EGCG is the main …
Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation.
Gutierrez-Salmean G, Ciaraldi TP, Nogueira L, Barboza J, Taub PR, Hogan MC, Henry RR, Meaney E, Villarreal F, Ceballos G, Ramirez-Sanchez I. Gutierrez-Salmean G, et al. Among authors: villarreal f. J Nutr Biochem. 2014 Jan;25(1):91-4. doi: 10.1016/j.jnutbio.2013.09.007. Epub 2013 Oct 18. J Nutr Biochem. 2014. PMID: 24314870 Free PMC article.
Flavonoids are known for their healthy effects and limited toxicity. The flavanol (-)-epicatechin (Epi) enhances exercise capacity in mice, and Epi-rich cocoa improves skeletal muscle structure in heart failure patients. (-)-Epicatechin may thus hold promise as trea …
Flavonoids are known for their healthy effects and limited toxicity. The flavanol (-)-epicatechin (Epi) enhances exercise capacity in …
(-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle.
Nogueira L, Ramirez-Sanchez I, Perkins GA, Murphy A, Taub PR, Ceballos G, Villarreal FJ, Hogan MC, Malek MH. Nogueira L, et al. Among authors: villarreal fj. J Physiol. 2011 Sep 15;589(Pt 18):4615-31. doi: 10.1113/jphysiol.2011.209924. Epub 2011 Jul 25. J Physiol. 2011. PMID: 21788351 Free PMC article.
The flavanol (-)-epicatechin, a component of cacao (cocoa), has been shown to have multiple health benefits in humans. ...Twenty-five male mice (C57BL/6N) were randomized into four groups: (1) water, (2) water-exercise (W-Ex), (3) (-)-epicatechin ((-)-Epi), and (4) …
The flavanol (-)-epicatechin, a component of cacao (cocoa), has been shown to have multiple health benefits in humans. ...Twenty-five …
11-beta-hydroxysterols as possible endogenous stimulators of mitochondrial biogenesis as inferred from epicatechin molecular mimicry.
Dugar S, Villarreal F, Hollinger FH, Mahajan D, Ramirez-Sanchez I, Moreno-Ulloa A, Ceballos G, Schreiner G. Dugar S, et al. Among authors: villarreal f. Pharmacol Res. 2020 Jan;151:104540. doi: 10.1016/j.phrs.2019.104540. Epub 2019 Nov 10. Pharmacol Res. 2020. PMID: 31722227
The molecular size of the cacao flavanols (epicatechin and catechin) highly resembles that of sterols and epicatechin has been reported to activate cells surface receptors leading to the stimulation of MB in endothelial and skeletal muscle cells translating i …
The molecular size of the cacao flavanols (epicatechin and catechin) highly resembles that of sterols and epicatechin h …
(-)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy.
McDonald CM, Ramirez-Sanchez I, Oskarsson B, Joyce N, Aguilar C, Nicorici A, Dayan J, Goude E, Abresch RT, Villarreal F, Ceballos G, Perkins G, Dugar S, Schreiner G, Henricson EK. McDonald CM, et al. Among authors: villarreal f. Muscle Nerve. 2021 Feb;63(2):239-249. doi: 10.1002/mus.27108. Epub 2020 Dec 16. Muscle Nerve. 2021. PMID: 33125736 Free PMC article.
INTRODUCTION: We conducted an open-label study to examine the effects of the flavonoid (-)-epicatechin in seven ambulatory adult patients with Becker muscular dystrophy (BMD). METHODS: Seven participants received (-)-epicatechin 50 mg twice per day for 8 weeks. ...T …
INTRODUCTION: We conducted an open-label study to examine the effects of the flavonoid (-)-epicatechin in seven ambulatory adult pati …
Positive Effects of (+)-Epicatechin on Traumatic Spinal Cord Injury Recovery.
Gonzalez-Ruiz C, Mondragón-Lozano R, Salgado-Ceballos H, Villarreal F, Martínez-Meza Y, Meaney E, Nájera N, Ceballos G. Gonzalez-Ruiz C, et al. Among authors: villarreal f. Biomolecules. 2025 Jun 14;15(6):869. doi: 10.3390/biom15060869. Biomolecules. 2025. PMID: 40563509 Free PMC article.
We evaluated the protective effects of the flavanol (+)-epicatechin (EC) in a rat model of moderate trauma-induced SCI on protein markers of damage events. ...The reduction in damage translates into better movement. The results suggest that (+)-epicatechin may be a …
We evaluated the protective effects of the flavanol (+)-epicatechin (EC) in a rat model of moderate trauma-induced SCI on protein mar …
Arginase inhibition by (-)-Epicatechin reverses endothelial cell aging.
Garate-Carrillo A, Navarrete-Yañez V, Ortiz-Vilchis P, Guevara G, Castillo C, Mendoza-Lorenzo P, Ceballos G, Ortiz-Flores M, Najera N, Bustamante-Pozo MM, Rubio-Gayosso I, Villarreal F, Ramirez-Sanchez I. Garate-Carrillo A, et al. Among authors: villarreal f. Eur J Pharmacol. 2020 Oct 15;885:173442. doi: 10.1016/j.ejphar.2020.173442. Epub 2020 Aug 11. Eur J Pharmacol. 2020. PMID: 32795514 Free PMC article.
The inhibition of Ar activity can reverse EnD and (-)-epicatechin (Epi) inhibits myocardial Ar activity. In this study, through in silico modeling we demonstrate that Epi interacts with Ar similarly to its inhibitor Norvaline (Norv). ...
The inhibition of Ar activity can reverse EnD and (-)-epicatechin (Epi) inhibits myocardial Ar activity. In this study, through in si …
60 results