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Clinical trials of targeted toxins.
Frankel AE, Tagge EP, Willingham MC. Frankel AE, et al. Semin Cancer Biol. 1995 Oct;6(5):307-17. doi: 10.1006/scbi.1995.0039. Semin Cancer Biol. 1995. PMID: 8562908 Review.
GMP production and characterization of the bivalent anti-human T cell immunotoxin, A-dmDT390-bisFv(UCHT1) for phase I/II clinical trials.
Woo JH, Liu JS, Kang SH, Singh R, Park SK, Su Y, Ortiz J, Neville DM Jr, Willingham MC, Frankel AE. Woo JH, et al. Protein Expr Purif. 2008 Mar;58(1):1-11. doi: 10.1016/j.pep.2007.11.006. Epub 2007 Nov 22. Protein Expr Purif. 2008. PMID: 18160309
Toxin conjugate therapy of cancer.
Wong L, Suh DY, Frankel AE. Wong L, et al. Semin Oncol. 2005 Dec;32(6):591-5. doi: 10.1053/j.seminoncol.2005.08.002. Semin Oncol. 2005. PMID: 16338425 Review.
Targeted toxins.
Frankel AE, Kreitman RJ, Sausville EA. Frankel AE, et al. Clin Cancer Res. 2000 Feb;6(2):326-34. Clin Cancer Res. 2000. PMID: 10690507 Review.
Expression of oligohistidine-tagged ricin B chain in Spodoptera frugiperda.
Afrin LB, Gulick H, Vesely J, Willingham M, Frankel AE. Afrin LB, et al. Bioconjug Chem. 1994 Nov-Dec;5(6):539-46. doi: 10.1021/bc00030a009. Bioconjug Chem. 1994. PMID: 7533004
Therapy of patients with T-cell lymphomas and leukemias using an anti-CD7 monoclonal antibody-ricin A chain immunotoxin.
Frankel AE, Laver JH, Willingham MC, Burns LJ, Kersey JH, Vallera DA. Frankel AE, et al. Leuk Lymphoma. 1997 Jul;26(3-4):287-98. doi: 10.3109/10428199709051778. Leuk Lymphoma. 1997. PMID: 9322891 Clinical Trial.
Ricin fusion toxin targeted to the human granulocyte-macrophage colony stimulating factor receptor is selectively toxic to acute myeloid leukemia cells.
Burbage C, Tagge EP, Harris B, Hall P, Fu T, Willingham MC, Frankel AE. Burbage C, et al. Leuk Res. 1997 Jul;21(7):681-90. doi: 10.1016/s0145-2126(97)00043-x. Leuk Res. 1997. PMID: 9301690
Ricin toxin contains three lectin sites which contribute to its in vivo toxicity.
Fu T, Burbage C, Tagge EP, Brothers T, Willingham MC, Frankel AE. Fu T, et al. Int J Immunopharmacol. 1996 Dec;18(12):685-92. doi: 10.1016/s0192-0561(97)85550-6. Int J Immunopharmacol. 1996. PMID: 9172011
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