Fraser PE - Search Results

1

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH. Sherrington R, et al. Among authors: fraser pe. Nature. 1995 Jun 29;375(6534):754-60. doi: 10.1038/375754a0. Nature. 1995. PMID: 7596406

2

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease.

Kisilevsky R, Lemieux LJ, Fraser PE, Kong X, Hultin PG, Szarek WA. Kisilevsky R, et al. Among authors: fraser pe. Nat Med. 1995 Feb;1(2):143-8. doi: 10.1038/nm0295-143. Nat Med. 1995. PMID: 7585011

3

Analysis of the functional effects of a mutation in SOD1 associated with familial amyotrophic lateral sclerosis.

Tsuda T, Munthasser S, Fraser PE, Percy ME, Rainero I, Vaula G, Pinessi L, Bergamini L, Vignocchi G, McLachlan DR, et al. Tsuda T, et al. Among authors: fraser pe. Neuron. 1994 Sep;13(3):727-36. doi: 10.1016/0896-6273(94)90039-6. Neuron. 1994. PMID: 7917302

4

Biochemistry of Alzheimer's disease amyloid plaques.

Fraser PE, Lévesque L, McLachlan DR. Fraser PE, et al. Clin Biochem. 1993 Oct;26(5):339-49. doi: 10.1016/0009-9120(93)90110-r. Clin Biochem. 1993. PMID: 8299204 Review.

5

Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: double-labeling immunohistochemical study.

Uchihara T, el Hachimi HK, Duyckaerts C, Foncin JF, Fraser PE, Levesque L, St George-Hyslop PH, Hauw JJ. Uchihara T, et al. Among authors: fraser pe. Acta Neuropathol. 1996 Oct;92(4):325-30. doi: 10.1007/s004010050526. Acta Neuropathol. 1996. PMID: 8891063

6

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.

Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ. Citron M, et al. Nat Med. 1997 Jan;3(1):67-72. doi: 10.1038/nm0197-67. Nat Med. 1997. PMID: 8986743

7

Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease.

Rogaev EI, Sherrington R, Wu C, Levesque G, Liang Y, Rogaeva EA, Ikeda M, Holman K, Lin C, Lukiw WJ, de Jong PJ, Fraser PE, Rommens JM, St George-Hyslop P. Rogaev EI, et al. Among authors: fraser pe. Genomics. 1997 Mar 15;40(3):415-24. doi: 10.1006/geno.1996.4523. Genomics. 1997. PMID: 9073509

8

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Seeger M, et al. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5090-4. doi: 10.1073/pnas.94.10.5090. Proc Natl Acad Sci U S A. 1997. PMID: 9144195 Free PMC article.

9

Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype.

Kwok JB, Taddei K, Hallupp M, Fisher C, Brooks WS, Broe GA, Hardy J, Fulham MJ, Nicholson GA, Stell R, St George Hyslop PH, Fraser PE, Kakulas B, Clarnette R, Relkin N, Gandy SE, Schofield PR, Martins RN. Kwok JB, et al. Among authors: fraser pe. Neuroreport. 1997 Apr 14;8(6):1537-42. doi: 10.1097/00001756-199704140-00043. Neuroreport. 1997. PMID: 9172170

10

Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.

Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Podlisny MB, et al. Neurobiol Dis. 1997;3(4):325-37. doi: 10.1006/nbdi.1997.0129. Neurobiol Dis. 1997. PMID: 9173929

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