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Biological interpretation of genome-wide association studies using predicted gene functions.
Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, Frayling T, Speliotes EK; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Boehnke M, Raychaudhuri S, Fehrmann RS, Hirschhorn JN, Franke L. Pers TH, et al. Among authors: frayling t. Nat Commun. 2015 Jan 19;6:5890. doi: 10.1038/ncomms6890. Nat Commun. 2015. PMID: 25597830 Free PMC article.
The role of the HNF4alpha enhancer in type 2 diabetes.
Mitchell SM, Gloyn AL, Owen KR, Hattersley AT, Frayling TM. Mitchell SM, et al. Among authors: frayling tm. Mol Genet Metab. 2002 Jun;76(2):148-51. doi: 10.1016/S1096-7192(02)00027-6. Mol Genet Metab. 2002. PMID: 12083813
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM. Gloyn AL, et al. Among authors: frayling tm. Diabetes. 2003 Feb;52(2):568-72. doi: 10.2337/diabetes.52.2.568. Diabetes. 2003. PMID: 12540637
A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity.
Frayling TM, Lindgren CM, Chevre JC, Menzel S, Wishart M, Benmezroua Y, Brown A, Evans JC, Rao PS, Dina C, Lecoeur C, Kanninen T, Almgren P, Bulman MP, Wang Y, Mills J, Wright-Pascoe R, Mahtani MM, Prisco F, Costa A, Cognet I, Hansen T, Pedersen O, Ellard S, Tuomi T, Groop LC, Froguel P, Hattersley AT, Vaxillaire M. Frayling TM, et al. Diabetes. 2003 Mar;52(3):872-81. doi: 10.2337/diabetes.52.3.872. Diabetes. 2003. PMID: 12606533
468 results