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Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.
Bioorg Med Chem Lett. 2011 Dec 1;21(23):7089-93. doi: 10.1016/j.bmcl.2011.09.109. Epub 2011 Oct 5.
Bioorg Med Chem Lett. 2011.
PMID: 22030030
Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket.
Frazzetto M, Suphioglu C, Zhu J, Schmidt-Kittler O, Jennings IG, Cranmer SL, Jackson SP, Kinzler KW, Vogelstein B, Thompson PE.
Frazzetto M, et al.
Biochem J. 2008 Sep 15;414(3):383-90. doi: 10.1042/BJ20080512.
Biochem J. 2008.
PMID: 18489260
Free PMC article.
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Synthesis and Pharmacological Evaluation of 4-Iminothiazolidinones for Inhibition of PI3 Kinase.
Pinson JA, Schmidt-Kittler O, Frazzetto M, Zheng Z, Jennings IG, Kinzler KW, Vogelstein B, Chalmers DK, Thompson PE.
Pinson JA, et al.
Aust J Chem. 2012 Jan 10;65(10):1396-1404. doi: 10.1071/CH12140.
Aust J Chem. 2012.
PMID: 23997244
Free PMC article.
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Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha.
Cranmer SL, Pikovski I, Mangin P, Thompson PE, Domagala T, Frazzetto M, Salem HH, Jackson SP.
Cranmer SL, et al.
Biochem J. 2005 May 1;387(Pt 3):849-58. doi: 10.1042/BJ20041836.
Biochem J. 2005.
PMID: 15574123
Free PMC article.
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CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo.
Burns CJ, Fantino E, Phillips ID, Su S, Harte MF, Bukczynska PE, Frazzetto M, Joffe M, Kruszelnicki I, Wang B, Wang Y, Wilson N, Dilley RJ, Wan SS, Charman SA, Shackleford DM, Fida R, Malcontenti-Wilson C, Wilks AF.
Burns CJ, et al.
Mol Cancer Ther. 2009 Nov;8(11):3036-45. doi: 10.1158/1535-7163.MCT-09-0076. Epub 2009 Nov 3.
Mol Cancer Ther. 2009.
PMID: 19887548
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