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93 results
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Applying genetics in inflammatory disease drug discovery.
Folkersen L, Biswas S, Frederiksen KS, Keller P, Fox B, Fleckner J. Folkersen L, et al. Among authors: frederiksen ks. Drug Discov Today. 2015 Oct;20(10):1176-81. doi: 10.1016/j.drudis.2015.05.012. Epub 2015 Jun 4. Drug Discov Today. 2015. PMID: 26050580
Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.
Mogensen JP, Jeppesen L, Bury PS, Pettersson I, Fleckner J, Nehlin J, Frederiksen KS, Albrektsen T, Din N, Mortensen SB, Svensson LA, Wassermann K, Wulff EM, Ynddal L, Sauerberg P. Mogensen JP, et al. Among authors: frederiksen ks. Bioorg Med Chem Lett. 2003 Jan 20;13(2):257-60. doi: 10.1016/s0960-894x(02)00881-8. Bioorg Med Chem Lett. 2003. PMID: 12482434
Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo.
Sauerberg P, Bury PS, Mogensen JP, Deussen HJ, Pettersson I, Fleckner J, Nehlin J, Frederiksen KS, Albrektsen T, Din N, Svensson LA, Ynddal L, Wulff EM, Jeppesen L. Sauerberg P, et al. Among authors: frederiksen ks. J Med Chem. 2003 Nov 6;46(23):4883-94. doi: 10.1021/jm0309046. J Med Chem. 2003. PMID: 14584939
The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.
Perucha E, Melchiotti R, Bibby JA, Wu W, Frederiksen KS, Roberts CA, Hall Z, LeFriec G, Robertson KA, Lavender P, Gerwien JG, Taams LS, Griffin JL, de Rinaldis E, van Baarsen LGM, Kemper C, Ghazal P, Cope AP. Perucha E, et al. Among authors: frederiksen ks. Nat Commun. 2019 Jan 30;10(1):498. doi: 10.1038/s41467-019-08332-9. Nat Commun. 2019. PMID: 30700717 Free PMC article.
Identification of novel type 1 diabetes candidate genes by integrating genome-wide association data, protein-protein interactions, and human pancreatic islet gene expression.
Bergholdt R, Brorsson C, Palleja A, Berchtold LA, Fløyel T, Bang-Berthelsen CH, Frederiksen KS, Jensen LJ, Størling J, Pociot F. Bergholdt R, et al. Among authors: frederiksen ks. Diabetes. 2012 Apr;61(4):954-62. doi: 10.2337/db11-1263. Epub 2012 Feb 16. Diabetes. 2012. PMID: 22344559 Free PMC article.
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