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One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology.
Ringholm A, Fredriksson R, Poliakova N, Yan YL, Postlethwait JH, Larhammar D, Schiöth HB. Ringholm A, et al. J Neurochem. 2002 Jul;82(1):6-18. doi: 10.1046/j.1471-4159.2002.00934.x. J Neurochem. 2002. PMID: 12091460
There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.
Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. Fredriksson R, et al. Biochem Biophys Res Commun. 2003 Feb 14;301(3):725-34. doi: 10.1016/s0006-291x(03)00026-3. Biochem Biophys Res Commun. 2003. PMID: 12565841
Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system.
Ringholm A, Klovins J, Fredriksson R, Poliakova N, Larson ET, Kukkonen JP, Larhammar D, Schiöth HB. Ringholm A, et al. Eur J Biochem. 2003 Jan;270(2):213-21. doi: 10.1046/j.1432-1033.2003.03371.x. Eur J Biochem. 2003. PMID: 12605672
Association of feather colour with constitutively active melanocortin 1 receptors in chicken.
Ling MK, Lagerström MC, Fredriksson R, Okimoto R, Mundy NI, Takeuchi S, Schiöth HB. Ling MK, et al. Eur J Biochem. 2003 Apr;270(7):1441-9. doi: 10.1046/j.1432-1033.2003.03506.x. Eur J Biochem. 2003. PMID: 12653999
Three of the cMC1 receptors; e(b), E and E(R), did not show any specific binding to the radioligand, but were found to be constitutively active in the cAMP assay. The E and E(R) alleles are associated with black feather colour in chicken while the eb allele gives ri …
Three of the cMC1 receptors; e(b), E and E(R), did not show any specific binding to the radioligand, but were found to be constitutiv …
Functional role, structure, and evolution of the melanocortin-4 receptor.
Schiöth HB, Lagerström MC, Watanobe H, Jonsson L, Vergoni AV, Ringholm A, Skarphedinsson JO, Skuladottir GV, Klovins J, Fredriksson R. Schiöth HB, et al. Ann N Y Acad Sci. 2003 Jun;994:74-83. doi: 10.1111/j.1749-6632.2003.tb03164.x. Ann N Y Acad Sci. 2003. PMID: 12851300 Review.
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