Freedman CJ - Search Results

1

A potent and selective inhibitor targeting human and murine 12/15-LOX.

Armstrong MM, Freedman CJ, Jung JE, Zheng Y, Kalyanaraman C, Jacobson MP, Simeonov A, Maloney DJ, van Leyen K, Jadhav A, Holman TR. Armstrong MM, et al. Among authors: freedman cj. Bioorg Med Chem. 2016 Mar 15;24(6):1183-90. doi: 10.1016/j.bmc.2016.01.042. Epub 2016 Jan 21. Bioorg Med Chem. 2016. PMID: 26899595 Free PMC article.

2

Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.

Freedman C, Tran A, Tourdot BE, Kalyanaraman C, Perry S, Holinstat M, Jacobson MP, Holman TR. Freedman C, et al. Biochemistry. 2020 May 19;59(19):1832-1844. doi: 10.1021/acs.biochem.0c00233. Epub 2020 May 7. Biochemistry. 2020. PMID: 32324389 Free PMC article.

3

Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase.

Deschamps JD, Ogunsola AF, Jameson JB 2nd, Yasgar A, Flitter BA, Freedman CJ, Melvin JA, Nguyen JV, Maloney DJ, Jadhav A, Simeonov A, Bomberger JM, Holman TR. Deschamps JD, et al. Among authors: freedman cj. Biochemistry. 2016 Jun 14;55(23):3329-40. doi: 10.1021/acs.biochem.6b00338. Epub 2016 Jun 3. Biochemistry. 2016. PMID: 27226387 Free PMC article.

4

5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.

Green AR, Freedman C, Tena J, Tourdot BE, Liu B, Holinstat M, Holman TR. Green AR, et al. Biochemistry. 2018 Dec 4;57(48):6726-6734. doi: 10.1021/acs.biochem.8b00889. Epub 2018 Nov 15. Biochemistry. 2018. PMID: 30407793 Free PMC article.

5

Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPARα-dependent manner.

Yeung J, Adili R, Yamaguchi A, Freedman CJ, Chen A, Shami R, Das A, Holman TR, Holinstat M. Yeung J, et al. Among authors: freedman cj. Blood Adv. 2020 Sep 22;4(18):4522-4537. doi: 10.1182/bloodadvances.2020002493. Blood Adv. 2020. PMID: 32946570 Free PMC article.

6

12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via Gαs Signaling in Platelets.

Yeung J, Tourdot BE, Adili R, Green AR, Freedman CJ, Fernandez-Perez P, Yu J, Holman TR, Holinstat M. Yeung J, et al. Among authors: freedman cj. Arterioscler Thromb Vasc Biol. 2016 Oct;36(10):2068-77. doi: 10.1161/ATVBAHA.116.308050. Epub 2016 Jul 28. Arterioscler Thromb Vasc Biol. 2016. PMID: 27470510 Free PMC article.

7

DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway.

Yamaguchi A, Stanger L, Freedman CJ, Standley M, Hoang T, Adili R, Tsai WC, van Hoorebeke C, Holman TR, Holinstat M. Yamaguchi A, et al. Among authors: freedman cj. J Thromb Haemost. 2021 Mar;19(3):839-851. doi: 10.1111/jth.15184. Epub 2020 Dec 16. J Thromb Haemost. 2021. PMID: 33222370 Free PMC article.

8

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium.

Dar HH, Tyurina YY, Mikulska-Ruminska K, Shrivastava I, Ting HC, Tyurin VA, Krieger J, St Croix CM, Watkins S, Bayir E, Mao G, Armbruster CR, Kapralov A, Wang H, Parsek MR, Anthonymuthu TS, Ogunsola AF, Flitter BA, Freedman CJ, Gaston JR, Holman TR, Pilewski JM, Greenberger JS, Mallampalli RK, Doi Y, Lee JS, Bahar I, Bomberger JM, Bayır H, Kagan VE. Dar HH, et al. Among authors: freedman cj. J Clin Invest. 2018 Oct 1;128(10):4639-4653. doi: 10.1172/JCI99490. Epub 2018 Sep 10. J Clin Invest. 2018. PMID: 30198910 Free PMC article.

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