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The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor.
Freeman M. Freeman M. Mech Dev. 1994 Oct;48(1):25-33. doi: 10.1016/0925-4773(94)90003-5. Mech Dev. 1994. PMID: 7833286
Rhomboids: 7 years of a new protease family.
Freeman M. Freeman M. Semin Cell Dev Biol. 2009 Apr;20(2):231-9. doi: 10.1016/j.semcdb.2008.10.006. Epub 2008 Oct 17. Semin Cell Dev Biol. 2009. PMID: 19022390 Review.
Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway.
Brown KE, Baonza A, Freeman M. Brown KE, et al. Among authors: freeman m. Dev Biol. 2006 Dec 15;300(2):710-21. doi: 10.1016/j.ydbio.2006.08.003. Epub 2006 Aug 9. Dev Biol. 2006. PMID: 16963016
Mammalian EGF receptor activation by the rhomboid protease RHBDL2.
Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M. Adrain C, et al. Among authors: freeman m. EMBO Rep. 2011 May;12(5):421-7. doi: 10.1038/embor.2011.50. Epub 2011 Apr 15. EMBO Rep. 2011. PMID: 21494248 Free PMC article.
Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.
Strisovsky K, Sharpe HJ, Freeman M. Strisovsky K, et al. Among authors: freeman m. Mol Cell. 2009 Dec 25;36(6):1048-59. doi: 10.1016/j.molcel.2009.11.006. Mol Cell. 2009. PMID: 20064469 Free PMC article.
The EGFR ligands Spitz and Keren act cooperatively in the Drosophila eye.
Brown KE, Kerr M, Freeman M. Brown KE, et al. Among authors: freeman m. Dev Biol. 2007 Jul 1;307(1):105-13. doi: 10.1016/j.ydbio.2007.04.025. Epub 2007 May 4. Dev Biol. 2007. PMID: 17512517
Control of cell proliferation in the Drosophila eye by Notch signaling.
Baonza A, Freeman M. Baonza A, et al. Among authors: freeman m. Dev Cell. 2005 Apr;8(4):529-39. doi: 10.1016/j.devcel.2005.01.019. Dev Cell. 2005. PMID: 15809035
EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development.
Urban S, Brown G, Freeman M. Urban S, et al. Among authors: freeman m. Development. 2004 Apr;131(8):1835-45. doi: 10.1242/dev.01058. Epub 2004 Mar 17. Development. 2004. PMID: 15084467
Proteolysis within the membrane: rhomboids revealed.
Freeman M. Freeman M. Nat Rev Mol Cell Biol. 2004 Mar;5(3):188-97. doi: 10.1038/nrm1334. Nat Rev Mol Cell Biol. 2004. PMID: 14990999 Review. No abstract available.
Diverse substrate recognition mechanisms for rhomboids; thrombomodulin is cleaved by Mammalian rhomboids.
Lohi O, Urban S, Freeman M. Lohi O, et al. Among authors: freeman m. Curr Biol. 2004 Feb 3;14(3):236-41. doi: 10.1016/j.cub.2004.01.025. Curr Biol. 2004. PMID: 14761657
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