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Effects of RNA secondary structure on cellular antisense activity.
Vickers TA, Wyatt JR, Freier SM. Vickers TA, et al. Nucleic Acids Res. 2000 Mar 15;28(6):1340-7. doi: 10.1093/nar/28.6.1340. Nucleic Acids Res. 2000. PMID: 10684928 Free PMC article.
Evaluation of pyrimidine PNA binding to ssDNA targets from nonequilibrium melting experiments.
Lesnik EA, Risen LM, Driver DA, Griffith MC, Sprankle K, Freier SM. Lesnik EA, et al. Nucleic Acids Res. 1997 Feb 1;25(3):568-74. doi: 10.1093/nar/25.3.568. Nucleic Acids Res. 1997. PMID: 9016597 Free PMC article.
Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo.
Monia BP, Sasmor H, Johnston JF, Freier SM, Lesnik EA, Muller M, Geiger T, Altmann KH, Moser H, Fabbro D. Monia BP, et al. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15481-4. doi: 10.1073/pnas.93.26.15481. Proc Natl Acad Sci U S A. 1996. PMID: 8986837 Free PMC article.
Kinetics of G-quartet-mediated tetramer formation.
Wyatt JR, Davis PW, Freier SM. Wyatt JR, et al. Biochemistry. 1996 Jun 18;35(24):8002-8. doi: 10.1021/bi960124h. Biochemistry. 1996. PMID: 8672504
Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets.
Kawasaki AM, Casper MD, Freier SM, Lesnik EA, Zounes MC, Cummins LL, Gonzalez C, Cook PD. Kawasaki AM, et al. J Med Chem. 1993 Apr 2;36(7):831-41. doi: 10.1021/jm00059a007. J Med Chem. 1993. PMID: 8464037
Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines.
Sanghvi YS, Hoke GD, Freier SM, Zounes MC, Gonzalez C, Cummins L, Sasmor H, Cook PD. Sanghvi YS, et al. Nucleic Acids Res. 1993 Jul 11;21(14):3197-203. doi: 10.1093/nar/21.14.3197. Nucleic Acids Res. 1993. PMID: 8393563 Free PMC article.
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