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Epidemiological time-trend of amyotrophic lateral sclerosis (ALS) over two decades: The French population-based register of ALS in Limousin (FRALim register).
Luna J, Defressigne O, Erazo D, Lautrette G, Raymondeau-Moustafa M, Preux PM, Boumediene F, Couratier P. Luna J, et al. Rev Neurol (Paris). 2022 Nov;178(9):914-923. doi: 10.1016/j.neurol.2022.05.004. Epub 2022 Sep 24. Rev Neurol (Paris). 2022. PMID: 36163089
INTRODUCTION: Population-based registers are key to understanding disease patterns. Taking advantage of the long-standing operation of the French register of amyotrophic lateral sclerosis (ALS) in Limousin (FRALim register), we sought to …
INTRODUCTION: Population-based registers are key to understanding disease patterns. Taking advantage of the long-standing operation o …
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial.
Bateman RJ, Li Y, McDade EM, Llibre-Guerra JJ, Clifford DB, Atri A, Mills SL, Santacruz AM, Wang G, Supnet C, Benzinger TLS, Gordon BA, Ibanez L, Klein G, Baudler M, Doody RS, Delmar P, Kerchner GA, Bittner T, Wojtowicz J, Bonni A, Fontoura P, Hofmann C, Kulic L, Hassenstab J, Aschenbrenner AJ, Perrin RJ, Cruchaga C, Renton AE, Xiong C, Goate AA, Morris JC, Holtzman DM, Snider BJ, Mummery C, Brooks WS, Wallon D, Berman SB, Roberson E, Masters CL, Galasko DR, Jayadev S, Sanchez-Valle R, Pariente J, Kinsella J, van Dyck CH, Gauthier S, Hsiung GR, Masellis M, Dubois B, Honig LS, Jack CR, Daniels A, Aguillón D, Allegri R, Chhatwal J, Day G, Fox NC, Huey E, Ikeuchi T, Jucker M, Lee JH, Levey AI, Levin J, Lopera F, Roh J, Rosa-Neto P, Schofield PR; Dominantly Inherited Alzheimer's Disease–Trials Unit. Bateman RJ, et al. Lancet Neurol. 2025 Apr;24(4):316-330. doi: 10.1016/S1474-4422(25)00024-9. Lancet Neurol. 2025. PMID: 40120616 Free PMC article. Clinical Trial.
DIAN-TU-001 (NCT01760005) and the OLE (NCT06424236) are registered with ClinicalTrials.gov. FINDINGS: Of 74 participants who were recruited into the OLE study between June 3, 2020, and April 22, 2021, 73 were enrolled and received gantenerumab treatment. 47 (64%) stopped d …
DIAN-TU-001 (NCT01760005) and the OLE (NCT06424236) are registered with ClinicalTrials.gov. FINDINGS: Of 74 participants who were rec …
Population-based epidemiology of amyotrophic lateral sclerosis (ALS) in an ageing Europe--the French register of ALS in Limousin (FRALim register).
Marin B, Hamidou B, Couratier P, Nicol M, Delzor A, Raymondeau M, Druet-Cabanac M, Lautrette G, Boumediene F, Preux PM; French register of ALS in Limousin. Marin B, et al. Eur J Neurol. 2014 Oct;21(10):1292-300, e78-9. doi: 10.1111/ene.12474. Epub 2014 Jun 9. Eur J Neurol. 2014. PMID: 24909935
BACKGROUND AND PURPOSE: The main objective of establishing the French register of amyotrophic lateral sclerosis (ALS) in the Limousin region (FRALim), was to assess the incidence of ALS, in this ageing region of Europe, over a 12-year period (20 …
BACKGROUND AND PURPOSE: The main objective of establishing the French register of amyotrophic lateral sclerosis (ALS) i …
Validity of death certificates in the identification of cases of amyotrophic lateral sclerosis (ALS) in the Limousin region, France. A population-based study.
Baldin E, Preux PM, Couratier P, Pugliatti M, Marin B; FRALIM CONSORTIUM. Baldin E, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2020 May;21(3-4):228-234. doi: 10.1080/21678421.2020.1746811. Epub 2020 Apr 10. Amyotroph Lateral Scler Frontotemporal Degener. 2020. PMID: 32276555
This study aims to assess the accuracy of DCs in the identification of ALS cases. Methods: This is a retrospective population-based validation study. DC information, provided by the "Centre d'epidemiologie sur les causes medicales de deces", including ICD10 codes for speci …
This study aims to assess the accuracy of DCs in the identification of ALS cases. Methods: This is a retrospective population-based v …
Checkpoint immunotherapy is associated with preferential activation of tumor antigen-specific CD4+ T cells in MDS.
Griffiths EA, Srivastava P, Gomez EC, Matsuzaki J, Odunsi K, Dillon LW, Mukherjee D, Hourigan CS, Peng J, Bandyopadhyay S, Tan K, Attwood KM, Kuechle JB, Singh PK, Wang J, Nemeth MJ. Griffiths EA, et al. Blood Neoplasia. 2025 Apr 25;2(3):100106. doi: 10.1016/j.bneo.2025.100106. eCollection 2025 Aug. Blood Neoplasia. 2025. PMID: 40809194 Free PMC article. Clinical Trial.
Approaches to augment the number and function of cDC1 populations in myeloid disease might overcome this defect and enhance the efficacy of immunotherapy for patients with MDS. This trial was registered at www.ClinicalTrials.gov as #NCT03358719....
Approaches to augment the number and function of cDC1 populations in myeloid disease might overcome this defect and enhance the efficacy of …
Reducing clinical trial eligibility barriers for patients with MDS: an icMDS position statement.
Borate U, Pugh K, Waller A, Welkie RL, Huang Y, Bewersdorf JP, Stahl M, DeZern AE, Platzbecker U, Sekeres MA, Wei AH, Buckstein RJ, Roboz GJ, Savona MR, Loghavi S, Hasserjian RP, Fenaux P, Sallman DA, Hourigan CS, Della Porta MG, Nimer S, Little RF, Santini V, Efficace F, Taylor J, Garcia-Manero G, Odenike O, Kim TK, Halene S, Komrokji RS, Griffiths EA, Greenberg PL, Xu ML, Xie Z, Bejar R, Sanz GF, Patnaik MM, Figueroa M, Carraway HE, Abdel-Wahab O, Starczynowski D, Padron E, Boultwood J, Gore S, Daver NG, Churpek JE, Majeti R, Bennett JM, List AF, Brunner AM, Zeidan AM. Borate U, et al. Blood. 2025 Mar 27;145(13):1369-1381. doi: 10.1182/blood.2023023717. Blood. 2025. PMID: 40146152 Free PMC article.
This study aims to evaluate the most common eligibility criteria according to phase of trial and to determine whether criteria correspond with drug safety signals. We identified MDS clinical trials registered on ClinicalTrials.gov from 1 January 2000 to 1 September 2023 an …
This study aims to evaluate the most common eligibility criteria according to phase of trial and to determine whether criteria correspond wi …
CPX-351 vs daunorubicin, cytarabine, and gemtuzumab ozogamicin in older adults with non-adverse-risk AML: the NCRI AML18 trial.
Knapper S, Dillon LW, Babu M, Thomas A, Thomas I, Hourigan CS, Andrew G, Dillon R, Gilkes A, Marquez Almuina N, King S, McCarthy N, Bahr R, Al-Ali RW, Stone L, Coats T, Byrne J, Green S, Overgaard UM, Sellar RS, Dennis M, Mehta P, Hills R, Freeman SD, Russell NH. Knapper S, et al. Blood. 2026 Mar 5;147(10):1048-1057. doi: 10.1182/blood.2025031006. Blood. 2026. PMID: 41237344 Free PMC article. Clinical Trial.
CPX did not benefit patients with MDS-related mutations over DAGO2. This trial was registered at www.ClinicalTrials.gov as #NCT02272478....
CPX did not benefit patients with MDS-related mutations over DAGO2. This trial was registered at www.ClinicalTrials.gov as #NCT022724 …
Why Does the Face Predict the Brain? Neural Crest Induction, Craniofacial Morphogenesis, and Neural Circuit Development.
LaMantia AS. LaMantia AS. Front Physiol. 2020 Dec 11;11:610970. doi: 10.3389/fphys.2020.610970. eCollection 2020. Front Physiol. 2020. PMID: 33362582 Free PMC article. Review.
This organizational principle is paralleled by central nervous system circuits that receive and process information from facial structures whose A-P identity is in register with that in the brain. Prior to morphogenesis of the face and its circuits, however, neural crest c …
This organizational principle is paralleled by central nervous system circuits that receive and process information from facial structures w …
Predictors of smoking cessation outcomes identified by machine learning: A systematic review.
Bickel WK, Tomlinson DC, Craft WH, Ma M, Dwyer CL, Yeh YH, Tegge AN, Freitas-Lemos R, Athamneh LN. Bickel WK, et al. Addict Neurosci. 2023 Jun;6:100068. doi: 10.1016/j.addicn.2023.100068. Epub 2023 Jan 31. Addict Neurosci. 2023. PMID: 37214256 Free PMC article.
In the current study, multiple searches occurred through December 9, 2022 in MEDLINE, Science Citation Index, Social Science Citation Index, EMBASE, CINAHL Plus, APA PsycINFO, PubMed, Cochrane Central Register of Controlled Trials, and the IEEE Xplore were performed. Inclu …
In the current study, multiple searches occurred through December 9, 2022 in MEDLINE, Science Citation Index, Social Science Citation Index, …
Aberrant early growth of individual trigeminal sensory and motor axons in a series of mouse genetic models of 22q11.2 deletion syndrome.
Motahari Z, Maynard TM, Popratiloff A, Moody SA, LaMantia AS. Motahari Z, et al. Hum Mol Genet. 2020 Nov 4;29(18):3081-3093. doi: 10.1093/hmg/ddaa199. Hum Mol Genet. 2020. PMID: 32901287 Free PMC article.
We assessed these phenotypes in three 22q11.2-related genotypes to determine whether individual CN V motor and sensory axons wander, branch and sprout aberrantly in register with altered anterior-posterior hindbrain patterning and gross morphological disruption of CN V see …
We assessed these phenotypes in three 22q11.2-related genotypes to determine whether individual CN V motor and sensory axons wander, branch …
20 results