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The following term was not found in PubMed: Freselestat
Page 1
ONO-6818 Cortech/Ono.
Trifilieff A. Trifilieff A. Curr Opin Investig Drugs. 2002 Aug;3(8):1161-4. Curr Opin Investig Drugs. 2002. PMID: 12211408 Review.
ONO-6818 (CP-955) is the lead compound in a series of orally bioavailable neutrophil elastase inhibitors licensed from Cortech and under investigation by Ono for the potential treatment of inflammatory conditions, such as rheumatoid arthritis, inflammatory bowel dis …
ONO-6818 (CP-955) is the lead compound in a series of orally bioavailable neutrophil elastase inhibitors licensed from Cortech …
ONO-6818, a novel, potent neutrophil elastase inhibitor, reduces inflammatory mediators during simulated extracorporeal circulation.
Yoshimura Y, Hiramatsu Y, Sato Y, Homma S, Enomoto Y, Jikuya T, Sakakibara Y. Yoshimura Y, et al. Ann Thorac Surg. 2003 Oct;76(4):1234-9. doi: 10.1016/s0003-4975(03)00878-6. Ann Thorac Surg. 2003. PMID: 14530017
RESULTS: Neutrophil elastase levels were significantly lower in the ONO-6818 group. ONO-6818 significantly reduced interleukin 8 and C5b-9 production. ONO-6818 did not modulate changes of CD11b and L-selectin during recirculation. ...
RESULTS: Neutrophil elastase levels were significantly lower in the ONO-6818 group. ONO-6818 significantly reduc …
A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats.
Kuraki T, Ishibashi M, Takayama M, Shiraishi M, Yoshida M. Kuraki T, et al. Am J Respir Crit Care Med. 2002 Aug 15;166(4):496-500. doi: 10.1164/rccm.2103118. Am J Respir Crit Care Med. 2002. PMID: 12186827
Young male Wistar rats were divided into four treatment groups: (1) control group (saline); (2) HNE group (HNE 200 U + 0.5% carboxymethyl-cellulose [solution for ONO-6818]); (3) low-dose ONO-6818 group (HNE 200 U + ONO-6818 10 mg/kg); and …
Young male Wistar rats were divided into four treatment groups: (1) control group (saline); (2) HNE group (HNE 200 U + 0.5% carboxymethyl-ce …
Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters.
Hirota Y, Suzuki M, Yamaguchi K, Fujita T, Katsube N. Hirota Y, et al. J Vet Med Sci. 2004 Oct;66(10):1223-8. doi: 10.1292/jvms.66.1223. J Vet Med Sci. 2004. PMID: 15528853 Free article.
We investigated the effects of an orally active NE inhibitor, ONO-6818, on acetic acid induced colitis in Syrian hamsters. The ulcer area, hemoglobin level in the colonic lumen, NE activity, and tissue myeloperoxidase (MPO) activity in the colitis control animals we …
We investigated the effects of an orally active NE inhibitor, ONO-6818, on acetic acid induced colitis in Syrian hamsters. The …
The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase.
Odagaki Y, Ohmoto K, Matsuoka S, Hamanaka N, Nakai H, Toda M, Katsuya Y. Odagaki Y, et al. Bioorg Med Chem. 2001 Mar;9(3):647-51. doi: 10.1016/s0968-0896(00)00277-7. Bioorg Med Chem. 2001. PMID: 11310599
The crystal structure of a new inhibitor of human neutrophil elastase (HNE), N-[2-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-(IRS)-1-(methylethyl)-2-oxoethyl]-2-(5-amino-6-oxo-2-phenyl-6H-pyrimidin-1-ly)acetamide (ONO-6818, 1) complexed to porcine pancreatic elastase (PP …
The crystal structure of a new inhibitor of human neutrophil elastase (HNE), N-[2-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-(IRS)-1-(methylethyl …
Neutrophil elastase inhibitors as treatment for COPD.
Ohbayashi H. Ohbayashi H. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. doi: 10.1517/13543784.11.7.965. Expert Opin Investig Drugs. 2002. PMID: 12084007 Review.
In the application of chronic obstructive pulmonary disease therapy, the human neutrophil elastase inhibitors mainly focused upon include ONO-5046, MR-889, L-694,458, CE-1037, GW-311616 and TEI-8362 as the acyl-enzyme inhibitors; and ONO-6818, AE-3763, FK-706, ICI-2 …
In the application of chronic obstructive pulmonary disease therapy, the human neutrophil elastase inhibitors mainly focused upon include ON …
Therapy for chronic obstructive pulmonary disease in the 21st century.
Donnelly LE, Rogers DF. Donnelly LE, et al. Drugs. 2003;63(19):1973-98. doi: 10.2165/00003495-200363190-00002. Drugs. 2003. PMID: 12962514 Review.
New antiproteases include acyl-enzyme and transition state inhibitors of neutrophil elastase (e.g. sivelestat and ONO-6818), matrix metalloprotease inhibitors (e.g. batimastat), cathepsin inhibitors and peptide protease inhibitors (e.g. ...
New antiproteases include acyl-enzyme and transition state inhibitors of neutrophil elastase (e.g. sivelestat and ONO-6818), m …
Novel benzoxazinone derivative as potent human neutrophil elastase inhibitor: Potential implications in lung injury.
Sengupta S, Reddy JR, Rajesh N, Jaiswal A, Mabalirajan U, Palakodety RK, Mukherjee P, Bandyopadhyay A. Sengupta S, et al. Eur J Pharmacol. 2022 Sep 15;931:175187. doi: 10.1016/j.ejphar.2022.175187. Epub 2022 Aug 8. Eur J Pharmacol. 2022. PMID: 35952844
While this inhibition is competitive based on substrate dilution assay, PD05 showed a high binding affinity for human neutrophil elastase (Kd = 1.63 nM) with faster association and dissociation rate compared to notable elastase inhibitors like ONO 6818 and AZD9668, …
While this inhibition is competitive based on substrate dilution assay, PD05 showed a high binding affinity for human neutrophil elastase (K …
Pathophysiological studies of trinitrobenzene sulfonic acid-induced colitis in Syrian hamsters (Mesocricetus auratus).
Hirota Y, Suzuki M, Yamaguchi K, Fujita T, Katsube N. Hirota Y, et al. Comp Med. 2005 Feb;55(1):45-54. Comp Med. 2005. PMID: 15766209
Although prednisolone had little effect on the tissue MPO activity, prednisolone inhibited the ulcer area and NE activity. In addition, the effects of an NE-specific inhibitor (ONO-6818) on our TNBS-induced colitis model were examined. In the subcutaneous treatment …
Although prednisolone had little effect on the tissue MPO activity, prednisolone inhibited the ulcer area and NE activity. In addition, the …
Design and synthesis of new orally active inhibitors of human neutrophil elastase.
Ohmoto K, Okuma M, Yamamoto T, Kijima H, Sekioka T, Kitagawa K, Yamamoto S, Tanaka K, Kawabata K, Sakata A, Imawaka H, Nakai H, Toda M. Ohmoto K, et al. Bioorg Med Chem. 2001 May;9(5):1307-23. doi: 10.1016/s0968-0896(01)00007-4. Bioorg Med Chem. 2001. PMID: 11377188
To identify new orally active inhibitors, further modification of 1 (ONO-6818) was performed. Peptidic derivatives 4b, 4c and 4n showed more potent inhibitory activity than nonpeptidic derivatives 3a-c. ...
To identify new orally active inhibitors, further modification of 1 (ONO-6818) was performed. Peptidic derivatives 4b, 4c and …
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