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Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease.
Salcedo C, Andersen JV, Vinten KT, Pinborg LH, Waagepetersen HS, Freude KK, Aldana BI. Salcedo C, et al. Among authors: freude kk. Front Aging Neurosci. 2021 Sep 17;13:736580. doi: 10.3389/fnagi.2021.736580. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34603012 Free PMC article.
Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B.
Zhang Y, Schmid B, Nikolaisen NK, Rasmussen MA, Aldana BI, Agger M, Calloe K, Stummann TC, Larsen HM, Nielsen TT, Huang J, Xu F, Liu X, Bolund L, Meyer M, Bak LK, Waagepetersen HS, Luo Y, Nielsen JE; FReJA Consortium; Holst B, Clausen C, Hyttel P, Freude KK. Zhang Y, et al. Among authors: freude kk. Stem Cell Reports. 2017 Mar 14;8(3):648-658. doi: 10.1016/j.stemcr.2017.01.012. Epub 2017 Feb 16. Stem Cell Reports. 2017. PMID: 28216144 Free PMC article.
Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons.
Aldana BI, Zhang Y, Lihme MF, Bak LK, Nielsen JE, Holst B, Hyttel P, Freude KK, Waagepetersen HS. Aldana BI, et al. Among authors: freude kk. Neurochem Int. 2017 Jun;106:48-61. doi: 10.1016/j.neuint.2017.02.010. Epub 2017 Feb 24. Neurochem Int. 2017. PMID: 28237843
Implications of Glycosylation in Alzheimer's Disease.
Haukedal H, Freude KK. Haukedal H, et al. Among authors: freude kk. Front Neurosci. 2021 Jan 13;14:625348. doi: 10.3389/fnins.2020.625348. eCollection 2020. Front Neurosci. 2021. PMID: 33519371 Free PMC article. Review.
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease.
Andersen JV, Skotte NH, Christensen SK, Polli FS, Shabani M, Markussen KH, Haukedal H, Westi EW, Diaz-delCastillo M, Sun RC, Kohlmeier KA, Schousboe A, Gentry MS, Tanila H, Freude KK, Aldana BI, Mann M, Waagepetersen HS. Andersen JV, et al. Among authors: freude kk. Cell Death Dis. 2021 Oct 16;12(11):954. doi: 10.1038/s41419-021-04237-y. Cell Death Dis. 2021. PMID: 34657143 Free PMC article.
Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3.
Chandrasekaran A, Dittlau KS, Corsi GI, Haukedal H, Doncheva NT, Ramakrishna S, Ambardar S, Salcedo C, Schmidt SI, Zhang Y, Cirera S, Pihl M, Schmid B, Nielsen TT, Nielsen JE, Kolko M, Kobolák J, Dinnyés A, Hyttel P, Palakodeti D, Gorodkin J, Muddashetty RS, Meyer M, Aldana BI, Freude KK. Chandrasekaran A, et al. Among authors: freude kk. Stem Cell Reports. 2021 Nov 9;16(11):2736-2751. doi: 10.1016/j.stemcr.2021.09.013. Epub 2021 Oct 21. Stem Cell Reports. 2021. PMID: 34678206 Free PMC article.
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