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Altered lung antioxidant status in patients with mild asthma.
Kelly FJ, Mudway I, Blomberg A, Frew A, Sandström T. Kelly FJ, et al. Among authors: frew a. Lancet. 1999 Aug 7;354(9177):482-3. doi: 10.1016/S0140-6736(99)01812-7. Lancet. 1999. PMID: 10465176
Differences in basal airway antioxidant concentrations are not predictive of individual responsiveness to ozone: a comparison of healthy and mild asthmatic subjects.
Mudway IS, Stenfors N, Blomberg A, Helleday R, Dunster C, Marklund SL, Frew AJ, Sandström T, Kelly FJ. Mudway IS, et al. Among authors: frew aj. Free Radic Biol Med. 2001 Oct 15;31(8):962-74. doi: 10.1016/s0891-5849(01)00671-2. Free Radic Biol Med. 2001. PMID: 11595381 Clinical Trial.
These responses have been proposed to arise as a consequence of the oxidizing nature of ozone, depleting endogenous antioxidant defenses with ensuing tissue injury. ...We observed a significant loss of ascorbate (ASC) from proximal (-45.1%, p <.01) and distal RTL …
These responses have been proposed to arise as a consequence of the oxidizing nature of ozone, depleting endogenous antioxidant defen …
Persistent airway inflammation but accommodated antioxidant and lung function responses after repeated daily exposure to nitrogen dioxide.
Blomberg A, Krishna MT, Helleday R, Söderberg M, Ledin MC, Kelly FJ, Frew AJ, Holgate ST, Sandström T. Blomberg A, et al. Among authors: frew aj. Am J Respir Crit Care Med. 1999 Feb;159(2):536-43. doi: 10.1164/ajrccm.159.2.9711068. Am J Respir Crit Care Med. 1999. PMID: 9927370 Clinical Trial.

Repeated NO2 exposure resulted in a decrease in neutrophil numbers in the bronchial epithelium. The BW revealed a twofold increase in content of neutrophils (p < 0.05) and a 1.5-fold increase in myeloperoxidase (MPO) (p < 0.01) indicative of both migrat

Repeated NO2 exposure resulted in a decrease in neutrophil numbers in the bronchial epithelium. The BW revealed a twofold incr …
Nasal cavity lining fluid ascorbic acid concentration increases in healthy human volunteers following short term exposure to diesel exhaust.
Blomberg A, Sainsbury C, Rudell B, Frew AJ, Holgate ST, Sandström T, Kelly FJ. Blomberg A, et al. Among authors: frew aj. Free Radic Res. 1998 Jan;28(1):59-67. doi: 10.3109/10715769809097876. Free Radic Res. 1998. PMID: 9554833 Clinical Trial.
To determine if diesel exhaust (DE) exposure modifies the antioxidant defense network within the respiratory tract lining fluids, a randomized, single blinded, crossover control study using nasal lavage and flexible video bronchoscopy with bronchial and bronchoalveolar lav …
To determine if diesel exhaust (DE) exposure modifies the antioxidant defense network within the respiratory tract lining fluids, a r …
Compromised concentrations of ascorbate in fluid lining the respiratory tract in human subjects after exposure to ozone.
Mudway IS, Krishna MT, Frew AJ, MacLeod D, Sandstrom T, Holgate ST, Kelly FJ. Mudway IS, et al. Among authors: frew aj. Occup Environ Med. 1999 Jul;56(7):473-81. doi: 10.1136/oem.56.7.473. Occup Environ Med. 1999. PMID: 10472319 Free PMC article. Clinical Trial.
Firstly, directly as a consequence of its oxidising character during exposure, and secondly, indirectly by engendering inflammation. ...These results imply that ascorbate has a critical protective role against inflammatory oxidative stress induced by O3....
Firstly, directly as a consequence of its oxidising character during exposure, and secondly, indirectly by engendering inflammation. …
Health effects of acute exposure to air pollution. Part I: Healthy and asthmatic subjects exposed to diesel exhaust.
Holgate ST, Sandström T, Frew AJ, Stenfors N, Nördenhall C, Salvi S, Blomberg A, Helleday R, Söderberg M. Holgate ST, et al. Among authors: frew aj. Res Rep Health Eff Inst. 2003 Dec;(112):1-30; discussion 51-67. Res Rep Health Eff Inst. 2003. PMID: 14738208 Clinical Trial.
We previously exposed control subjects for 1 hour to a high ambient concentration of diesel exhaust (particle concentration 300 pg/m3--a level comparable with that found in North Sea ferries, highway underpasses, etc). ...For this study, we used a lower conce …
We previously exposed control subjects for 1 hour to a high ambient concentration of diesel exhaust (particle concentration 300 pg/m3 …
Vitamin supplementation does not protect against symptoms in ozone-responsive subjects.
Mudway IS, Behndig AF, Helleday R, Pourazar J, Frew AJ, Kelly FJ, Blomberg A. Mudway IS, et al. Among authors: frew aj. Free Radic Biol Med. 2006 May 15;40(10):1702-12. doi: 10.1016/j.freeradbiomed.2005.10.050. Free Radic Biol Med. 2006. PMID: 16767844 Clinical Trial.
To confirm whether supplementation with vitamins C and E could reduce lung function decrements, airway inflammation, and epithelial injury in subjects sensitive to ozone, a double-blinded, crossover control study was performed. ...Similarly, ozone-induced neutrophilia were …
To confirm whether supplementation with vitamins C and E could reduce lung function decrements, airway inflammation, and epithelial injury i …
Effects of controlled diesel exhaust exposure on apoptosis and proliferation markers in bronchial epithelium - an in vivo bronchoscopy study on asthmatics, rhinitics and healthy subjects.
Behndig AF, Shanmuganathan K, Whitmarsh L, Stenfors N, Brown JL, Frew AJ, Kelly FJ, Mudway IS, Sandström T, Wilson SJ. Behndig AF, et al. Among authors: frew aj. BMC Pulm Med. 2015 Aug 25;15:99. doi: 10.1186/s12890-015-0096-x. BMC Pulm Med. 2015. PMID: 26303256 Free PMC article.
BACKGROUND: Epidemiological evidence demonstrates that exposure to traffic-derived pollution worsens respiratory symptoms in asthmatics, but controlled human exposure studies have failed to provide a mechanism for this effect. ...Bronchial biopsies were taken 18 h post-exp …
BACKGROUND: Epidemiological evidence demonstrates that exposure to traffic-derived pollution worsens respiratory symptoms in asthmatics, but …
An in vitro and in vivo investigation of the effects of diesel exhaust on human airway lining fluid antioxidants.
Mudway IS, Stenfors N, Duggan ST, Roxborough H, Zielinski H, Marklund SL, Blomberg A, Frew AJ, Sandström T, Kelly FJ. Mudway IS, et al. Among authors: frew aj. Arch Biochem Biophys. 2004 Mar 1;423(1):200-12. doi: 10.1016/j.abb.2003.12.018. Arch Biochem Biophys. 2004. PMID: 14871482
Immediately following DE exposure, subjects displayed an increase in subjective symptoms and a mild bronchoconstriction. Six hours following the cessation of DE exposure neither airway inflammation, nor antioxidant depletion (ascorbate, urate, and reduced glutathione), was …
Immediately following DE exposure, subjects displayed an increase in subjective symptoms and a mild bronchoconstriction. Six hours fo …
Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans.
Behndig AF, Mudway IS, Brown JL, Stenfors N, Helleday R, Duggan ST, Wilson SJ, Boman C, Cassee FR, Frew AJ, Kelly FJ, Sandström T, Blomberg A. Behndig AF, et al. Among authors: frew aj. Eur Respir J. 2006 Feb;27(2):359-65. doi: 10.1183/09031936.06.00136904. Eur Respir J. 2006. PMID: 16452593 Clinical Trial.
Pulmonary cells exposed to diesel exhaust (DE) particles in vitro respond in a hierarchical fashion with protective antioxidant responses predominating at low doses and inflammation and injury only occurring at higher concentrations. ...A total of 15 volunteers were …
Pulmonary cells exposed to diesel exhaust (DE) particles in vitro respond in a hierarchical fashion with protective antioxidant respo …
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