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Genetic interactions between mutants of the 'error-prone' repair group of Saccharomyces cerevisiae and their effect on recombination and mutagenesis.
Liefshitz B, Steinlauf R, Friedl A, Eckardt-Schupp F, Kupiec M. Liefshitz B, et al. Among authors: friedl a. Mutat Res. 1998 Mar;407(2):135-45. doi: 10.1016/s0921-8777(97)00070-0. Mutat Res. 1998. PMID: 9637242
Liefshitz, A. Parket, R. Maya, M. Kupiec, The role of DNA repair genes in recombination between repeated sequences in yeast, Genetics 140 (1995) 1199-1211.]. ...In contrast, RAD5 and RAD18 play alternative roles in mutagenic repair: mutations in each of these genes elevate …
Liefshitz, A. Parket, R. Maya, M. Kupiec, The role of DNA repair genes in recombination between repeated sequences in yeast, Genetics …
A new X-ray sensitive CHO cell mutant of ionizing radiation group 7,XR-C2, that is defective in DSB repair but has only a mild defect in V(D)J recombination.
Errami A, Overkamp WJ, He DM, Friedl AA, Gell DA, Eckardt-Schupp F, Jackson SP, Hendrickson EA, Lohman PH, Zdzienicka MZ. Errami A, et al. Among authors: friedl aa. Mutat Res. 2000 Sep 15;461(1):59-69. doi: 10.1016/s0921-8777(00)00038-0. Mutat Res. 2000. PMID: 10980412
The DNA-dependent protein kinase (DNA-PK) complex plays a key role in DNA double-strand break (DSB) repair and V(D)J recombination. ...In contrast to other IR group 7 mutants, which contain undetectable or low levels of DNA-PKcs protein and which show a severe defec …
The DNA-dependent protein kinase (DNA-PK) complex plays a key role in DNA double-strand break (DSB) repair and V(D)J recombination. . …
Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts.
Kraakman-van der Zwet M, Overkamp WJ, Friedl AA, Klein B, Verhaegh GW, Jaspers NG, Midro AT, Eckardt-Schupp F, Lohman PH, Zdzienicka MZ. Kraakman-van der Zwet M, et al. Among authors: friedl aa. Mutat Res. 1999 May 14;434(1):17-27. doi: 10.1016/s0921-8777(99)00009-9. Mutat Res. 1999. PMID: 10377945
Nijmegen Breakage Syndrome (NBS) is a very rare autosomal recessive chromosomal instability disorder characterized by microcephaly, growth retardation, immunodeficiency and a high incidence of malignancies. ...NBS is caused by mutations in the NBS1 gene on chromosom …
Nijmegen Breakage Syndrome (NBS) is a very rare autosomal recessive chromosomal instability disorder characterized by microcephaly, g …
Role of Artemis in DSB repair and guarding chromosomal stability following exposure to ionizing radiation at different stages of cell cycle.
Darroudi F, Wiegant W, Meijers M, Friedl AA, van der Burg M, Fomina J, van Dongen JJ, van Gent DC, Zdzienicka MZ. Darroudi F, et al. Among authors: friedl aa. Mutat Res. 2007 Feb 3;615(1-2):111-24. doi: 10.1016/j.mrfmmm.2006.11.029. Epub 2006 Dec 12. Mutat Res. 2007. PMID: 17169382
Irradiation in G(2) resulted in a higher frequency of chromatid-type aberrations (1.5-3-fold) than in normal cells, indicating that a fraction of DSB requires Artemis for proper repair. Our data are consistent with a function of Artemis protein in processing …
Irradiation in G(2) resulted in a higher frequency of chromatid-type aberrations (1.5-3-fold) than in normal cells, indicating that …
Promoter-trapping in Saccharomyces cerevisiae by radiation-assisted fragment insertion.
Kiechle M, Manivasakam P, Eckardt-Schupp F, Schiestl RH, Friedl AA. Kiechle M, et al. Among authors: friedl aa. Nucleic Acids Res. 2002 Dec 15;30(24):e136. doi: 10.1093/nar/gnf136. Nucleic Acids Res. 2002. PMID: 12490727 Free PMC article.
Non-homologous insertion (NHI) of DNA fragments into genomic DNA is a method widely used in insertional mutagenesis screens. ...In a pilot study, we generated 102 transformant clones expressing a lacZ reporter gene under standard conditions (30 degrees C, ric …
Non-homologous insertion (NHI) of DNA fragments into genomic DNA is a method widely used in insertional mutagenesis screens. ...In …
Subtelomeric repeat amplification is associated with growth at elevated temperature in yku70 mutants of Saccharomyces cerevisiae.
Fellerhoff B, Eckardt-Schupp F, Friedl AA. Fellerhoff B, et al. Among authors: friedl aa. Genetics. 2000 Mar;154(3):1039-51. Genetics. 2000. PMID: 10757752 Free PMC article.
Inactivation of the Saccharomyces cerevisiae gene YKU70 (HDF1), which encodes one subunit of the Ku heterodimer, confers a DNA double-strand break repair defect, shortening of and structural alterations in the telomeres, and a severe growth defect at 37 degrees. ... …
Inactivation of the Saccharomyces cerevisiae gene YKU70 (HDF1), which encodes one subunit of the Ku heterodimer, confers a DNA double …
The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination.
Siede W, Friedl AA, Dianova I, Eckardt-Schupp F, Friedberg EC. Siede W, et al. Among authors: friedl aa. Genetics. 1996 Jan;142(1):91-102. Genetics. 1996. PMID: 8770587 Free PMC article.
In the yeast Saccharomyces cerevisiae, we have examined the phenotype conferred by a deletion of HDF1, the putative homologue of the 70-kD subunit of the DNA-end binding Ku complex of DNA-PK. The yeast gene does not play a role in radiation-induced cell cycle checkp …
In the yeast Saccharomyces cerevisiae, we have examined the phenotype conferred by a deletion of HDF1, the putative homologue of the …
Radiation-induced chromosome aberrations in Saccharomyces cerevisiae: influence of DNA repair pathways.
Friedl AA, Kiechle M, Fellerhoff B, Eckardt-Schupp F. Friedl AA, et al. Genetics. 1998 Mar;148(3):975-88. Genetics. 1998. PMID: 9539418 Free PMC article.
In the rad52 and the rad54 strains, enhanced formation of aberrations, mostly exchange-type aberrations, was detected, demonstrating the misrepair activity of a rejoining mechanism other than homologous recombination. ...Hence, misrepair resulting in exchange-type aberrati …
In the rad52 and the rad54 strains, enhanced formation of aberrations, mostly exchange-type aberrations, was detected, demonstrating the mis …
Deletion of the SRS2 gene suppresses elevated recombination and DNA damage sensitivity in rad5 and rad18 mutants of Saccharomyces cerevisiae.
Friedl AA, Liefshitz B, Steinlauf R, Kupiec M. Friedl AA, et al. Mutat Res. 2001 Jul 12;486(2):137-46. doi: 10.1016/s0921-8777(01)00086-6. Mutat Res. 2001. PMID: 11425518
We propose a model in which the Srs2 protein has pro-recombinogenic or anti-recombinogenic activity, depending on the context of the DNA damage....
We propose a model in which the Srs2 protein has pro-recombinogenic or anti-recombinogenic activity, depending on the context of the …
Nanoscopic analysis of 53BP1, BRCA1 and Rad51 reveals new insights in temporal progression of DNA-repair and pathway choice.
Schwarz B, Friedl AA, Girst S, Dollinger G, Reindl J. Schwarz B, et al. Among authors: friedl aa. Mutat Res. 2019 Nov;816-818:111675. doi: 10.1016/j.mrfmmm.2019.111675. Epub 2019 Jun 28. Mutat Res. 2019. PMID: 31302572
At this stage, almost all IRIF in a given Rad51-positive cell show Rad51 accumulation, suggesting that repair via homologous recombination is attempted at almost all residual DSB sites. ...Correlation analysis showed a high degree of correlation of Rad51 with BRCA1, …
At this stage, almost all IRIF in a given Rad51-positive cell show Rad51 accumulation, suggesting that repair via homologous recombin …
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