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Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.
Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Wesolowski SR, et al. Among authors: friedman je. Mol Metab. 2018 Dec;18:25-41. doi: 10.1016/j.molmet.2018.09.008. Epub 2018 Sep 28. Mol Metab. 2018. PMID: 30337225 Free PMC article.
Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B. Barbour LA, et al. Among authors: friedman je. J Biol Chem. 2005 Nov 11;280(45):37489-94. doi: 10.1074/jbc.M506967200. Epub 2005 Sep 8. J Biol Chem. 2005. PMID: 16166093 Free article.
CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice.
Schroeder-Gloeckler JM, Rahman SM, Janssen RC, Qiao L, Shao J, Roper M, Fischer SJ, Lowe E, Orlicky DJ, McManaman JL, Palmer C, Gitomer WL, Huang W, O'Doherty RM, Becker TC, Klemm DJ, Jensen DR, Pulawa LK, Eckel RH, Friedman JE. Schroeder-Gloeckler JM, et al. Among authors: friedman je. J Biol Chem. 2007 May 25;282(21):15717-29. doi: 10.1074/jbc.M701329200. Epub 2007 Mar 26. J Biol Chem. 2007. PMID: 17387171 Free PMC article.
Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.
Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, Friedman JE, Eckel RH. Wang H, et al. Among authors: friedman je. Diabetes. 2009 Jan;58(1):116-24. doi: 10.2337/db07-1839. Epub 2008 Oct 24. Diabetes. 2009. PMID: 18952837 Free PMC article.
248 results