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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1972 2
1973 1
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1984 1
1985 1
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1987 2
1988 1
1991 1
1994 3
1995 3
1996 3
1997 5
1998 3
1999 8
2000 8
2001 11
2002 5
2003 8
2004 8
2005 4
2006 8
2007 8
2008 5
2009 10
2010 10
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2016 13
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2018 5
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2024 10

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207 results

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Page 1
Friedreich ataxia: clinical features and new developments.
Keita M, McIntyre K, Rodden LN, Schadt K, Lynch DR. Keita M, et al. Neurodegener Dis Manag. 2022 Oct;12(5):267-283. doi: 10.2217/nmt-2022-0011. Epub 2022 Jun 29. Neurodegener Dis Manag. 2022. PMID: 35766110 Free PMC article. Review.
Friedreich's ataxia (FRDA), a neurodegenerative disease characterized by ataxia and other neurological features, affects 1 in 50,000-100,000 individuals in the USA. ...Finally, new perspectives on the neuroanatomy of FRDA and its developmental features …
Friedreich's ataxia (FRDA), a neurodegenerative disease characterized by ataxia and other neurological features, affect …
Friedreich's ataxia: clinical features, pathogenesis and management.
Cook A, Giunti P. Cook A, et al. Br Med Bull. 2017 Dec 1;124(1):19-30. doi: 10.1093/bmb/ldx034. Br Med Bull. 2017. PMID: 29053830 Free PMC article. Review.
INTRODUCTION: Friedreich's ataxia is the most common inherited ataxia. SOURCES OF DATA: Literature search using PubMed with keywords Friedreich's ataxia together with published papers known to the authors. ...AREAS TIMELY FOR DEVELOPING RESEARCH …
INTRODUCTION: Friedreich's ataxia is the most common inherited ataxia. SOURCES OF DATA: Literature search using PubMed …
Evaluation of Cerebellar Ataxic Patients.
Radmard S, Zesiewicz TA, Kuo SH. Radmard S, et al. Neurol Clin. 2023 Feb;41(1):21-44. doi: 10.1016/j.ncl.2022.05.002. Epub 2022 Aug 31. Neurol Clin. 2023. PMID: 36400556 Free PMC article. Review.
There are many genetic causes for cerebellar ataxia, and the common autosomal dominant and recessive ataxia are due to genetic repeat expansions. ...Symptomatic and potential disease-modifying therapies may benefit patients with cerebellar ataxia....
There are many genetic causes for cerebellar ataxia, and the common autosomal dominant and recessive ataxia are due to genetic …
Friedreich ataxia- pathogenesis and implications for therapies.
Delatycki MB, Bidichandani SI. Delatycki MB, et al. Neurobiol Dis. 2019 Dec;132:104606. doi: 10.1016/j.nbd.2019.104606. Epub 2019 Sep 5. Neurobiol Dis. 2019. PMID: 31494282 Free article. Review.
Friedreich ataxia is the most common of the hereditary ataxias. It is due to homozygous/compound heterozygous mutations in FXN. ...In about 96% of affected individuals there is homozygosity for a GAA repeat expansion in intron 1 of the FXN gene. Studies of pe …
Friedreich ataxia is the most common of the hereditary ataxias. It is due to homozygous/compound heterozygous mutations in FXN …
Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders.
Islam MT. Islam MT. Neurol Res. 2017 Jan;39(1):73-82. doi: 10.1080/01616412.2016.1251711. Epub 2016 Nov 3. Neurol Res. 2017. PMID: 27809706 Review.
Oxidative stress has been considered to be linked to the etiology of many diseases, including neurodegenerative diseases (NDDs) such as Alzheimer diseases, Amyotrophic lateral sclerosis, Friedreich's ataxia, Huntington's disease, Multiple sclerosis, and Parkinson's …
Oxidative stress has been considered to be linked to the etiology of many diseases, including neurodegenerative diseases (NDDs) such as Alzh …
Molecular mechanisms of ferroptosis and their involvement in brain diseases.
Costa I, Barbosa DJ, Benfeito S, Silva V, Chavarria D, Borges F, Remião F, Silva R. Costa I, et al. Pharmacol Ther. 2023 Apr;244:108373. doi: 10.1016/j.pharmthera.2023.108373. Epub 2023 Mar 8. Pharmacol Ther. 2023. PMID: 36894028 Free article. Review.
On the other side, ferroptosis inhibitors include ferrostatin-1, liproxstatin-1, alpha-tocopherol, zileuton, FSP1, CoQ10 and BH4, which interrupt the lipid peroxidation cascade. ...Increased evidence has established the involvement of ferroptosis in distinct brain d …
On the other side, ferroptosis inhibitors include ferrostatin-1, liproxstatin-1, alpha-tocopherol, zileuton, FSP1, CoQ10 and B …
The inherited cerebellar ataxias: an update.
Coarelli G, Wirth T, Tranchant C, Koenig M, Durr A, Anheim M. Coarelli G, et al. J Neurol. 2023 Jan;270(1):208-222. doi: 10.1007/s00415-022-11383-6. Epub 2022 Sep 24. J Neurol. 2023. PMID: 36152050 Free PMC article. Review.
We also report on key clinical points for the diagnosis of the main ICAs, including Friedreich ataxia, CANVAS, polyglutamine spinocerebellar ataxias, Fragile X-associated tremor/ataxia syndrome. ...To complicate the phenotype, cerebellar cognitive affective s …
We also report on key clinical points for the diagnosis of the main ICAs, including Friedreich ataxia, CANVAS, polyglutamine s …
The global epidemiology of hereditary ataxia and spastic paraplegia: a systematic review of prevalence studies.
Ruano L, Melo C, Silva MC, Coutinho P. Ruano L, et al. Neuroepidemiology. 2014;42(3):174-83. doi: 10.1159/000358801. Epub 2014 Mar 5. Neuroepidemiology. 2014. PMID: 24603320 Free article. Review.
The prevalence range of dominant HCA was 0.0-5.6/10(5), with an average of 2.7/10(5) (1.5-4.0/10(5)). Spinocerebellar ataxia type 3 (SCA3)/Machado-Joseph disease was the most common dominant ataxia, followed by SCA2 and SCA6. The autosomal recessive (AR) HCA …
The prevalence range of dominant HCA was 0.0-5.6/10(5), with an average of 2.7/10(5) (1.5-4.0/10(5)). Spinocerebellar ataxia t …
Diagnosis and Management of Cardiovascular Involvement in Friedreich Ataxia.
Monda E, Lioncino M, Rubino M, Passantino S, Verrillo F, Caiazza M, Cirillo A, Fusco A, Di Fraia F, Fimiani F, Amodio F, Borrelli N, Mauriello A, Natale F, Scarano G, Girolami F, Favilli S, Limongelli G. Monda E, et al. Heart Fail Clin. 2022 Jan;18(1):31-37. doi: 10.1016/j.hfc.2021.07.001. Epub 2021 Oct 25. Heart Fail Clin. 2022. PMID: 34776081 Review.
Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by a homozygous GAA triplet repeat expansion in the frataxin gene. ...
Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by a homozygous GAA triplet repeat expans …
New and Emerging Drug and Gene Therapies for Friedreich Ataxia.
Scott V, Delatycki MB, Tai G, Corben LA. Scott V, et al. CNS Drugs. 2024 Oct;38(10):791-805. doi: 10.1007/s40263-024-01113-z. Epub 2024 Aug 8. CNS Drugs. 2024. PMID: 39115603 Free PMC article. Review.
The life shortening nature of Friedreich Ataxia (FRDA) demands the search for therapies that can delay, stop or reverse its relentless trajectory. This review provides a contemporary position of drug and gene therapies for FRDA currently in phase 1 clinical t …
The life shortening nature of Friedreich Ataxia (FRDA) demands the search for therapies that can delay, stop or reverse its re …
207 results