Friedrich S - Search Results

1

The pharmacokinetics and pharmacokinetic/pharmacodynamic relationships of evacetrapib administered as monotherapy or in combination with statins.

Friedrich S, Kastelein JJ, James D, Waterhouse T, Nissen SE, Nicholls SJ, Krueger KA. Friedrich S, et al. CPT Pharmacometrics Syst Pharmacol. 2014 Jan 22;3(1):e94. doi: 10.1038/psp.2013.70. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 24452615 Free PMC article.

2

Evacetrapib at a supratherapeutic steady state concentration does not prolong QT in a thorough QT/QTc study in healthy participants.

Suico JG, Friedrich S, Krueger KA, Zhang W. Suico JG, et al. Among authors: friedrich s. J Cardiovasc Pharmacol Ther. 2014 May;19(3):283-9. doi: 10.1177/1074248413510784. Epub 2013 Nov 22. J Cardiovasc Pharmacol Ther. 2014. PMID: 24271137 Clinical Trial.

3

Effects of the cholesteryl ester transfer protein inhibitor evacetrapib on lipoproteins, apolipoproteins and 24-h ambulatory blood pressure in healthy adults.

Suico JG, Wang MD, Friedrich S, Cannady EA, Konkoy CS, Ruotolo G, Krueger KA. Suico JG, et al. Among authors: friedrich s. J Pharm Pharmacol. 2014 Nov;66(11):1576-85. doi: 10.1111/jphp.12287. Epub 2014 Jun 24. J Pharm Pharmacol. 2014. PMID: 24961753 Free PMC article. Clinical Trial.

4

Assessment of the persistence of anacetrapib and evacetrapib concentrations using two pharmacokinetic modeling approaches.

Small DS, Ke AB, Hall SD, Mantlo N, Rotelli M, Friedrich S. Small DS, et al. Among authors: friedrich s. J Clin Pharmacol. 2015 Jul;55(7):757-67. doi: 10.1002/jcph.472. Epub 2015 Feb 20. J Clin Pharmacol. 2015. PMID: 25651523

5

CYP-mediated drug-drug interactions with evacetrapib, an investigational CETP inhibitor: in vitro prediction and clinical outcome.

Cannady EA, Suico JG, Wang MD, Friedrich S, Rehmel JR, Nicholls SJ, Krueger KA. Cannady EA, et al. Among authors: friedrich s. Br J Clin Pharmacol. 2015 Dec;80(6):1388-98. doi: 10.1111/bcp.12730. Epub 2015 Oct 27. Br J Clin Pharmacol. 2015. PMID: 26264702 Free PMC article. Clinical Trial.

6

Efficacy and Safety of Continued Treatment With Mirikizumab in a Phase 2 Trial of Patients With Ulcerative Colitis.

Sandborn WJ, Ferrante M, Bhandari BR, Berliba E, Hibi T, D'Haens GR, Tuttle JL, Krueger K, Friedrich S, Durante M, Arora V, Naegeli AN, Schmitz J, Feagan BG. Sandborn WJ, et al. Among authors: friedrich s. Clin Gastroenterol Hepatol. 2022 Jan;20(1):105-115.e14. doi: 10.1016/j.cgh.2020.09.028. Epub 2020 Sep 18. Clin Gastroenterol Hepatol. 2022. PMID: 32950748 Free article. Clinical Trial.

7

Semagacestat pharmacokinetics are not significantly affected by formulation, food, or time of dosing in healthy participants.

Willis BA, Zhang W, Ayan-Oshodi M, Lowe SL, Annes WF, Sirois PJ, Friedrich S, de la Peña A. Willis BA, et al. Among authors: friedrich s. J Clin Pharmacol. 2012 Jun;52(6):904-13. doi: 10.1177/0091270011407195. Epub 2011 Jul 1. J Clin Pharmacol. 2012. PMID: 21724950 Clinical Trial.

8

A Multidose Study to Examine the Effect of Food on Evacetrapib Exposure at Steady State.

Small DS, Zhang W, Royalty J, Cannady EA, Downs D, Friedrich S, Suico JG. Small DS, et al. Among authors: friedrich s. J Cardiovasc Pharmacol Ther. 2015 Sep;20(5):483-9. doi: 10.1177/1074248415575153. Epub 2015 Mar 3. J Cardiovasc Pharmacol Ther. 2015. PMID: 25736283 Free PMC article. Clinical Trial.

9

Evacetrapib: in vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors.

Cannady EA, Wang MD, Friedrich S, Rehmel JL, Yi P, Small DS, Zhang W, Suico JG. Cannady EA, et al. Among authors: friedrich s. Pharmacol Res Perspect. 2015 Oct;3(5):e00179. doi: 10.1002/prp2.179. Epub 2015 Oct 12. Pharmacol Res Perspect. 2015. PMID: 26516590 Free PMC article.

10

Exposure-Response Modeling to Characterize the Relationship Between Ixekizumab Serum Drug Concentrations and Efficacy Responses at Week 12 in Patients With Moderate to Severe Plaque Psoriasis.

Chigutsa E, Velez de Mendizabal N, Chua L, Heathman M, Friedrich S, Jackson K, Reich K. Chigutsa E, et al. Among authors: friedrich s. J Clin Pharmacol. 2018 Nov;58(11):1489-1500. doi: 10.1002/jcph.1268. Epub 2018 Jun 7. J Clin Pharmacol. 2018. PMID: 29878382 Clinical Trial.

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