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244 results
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Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells.
Friesen C, Herr I, Krammer PH, Debatin KM. Friesen C, et al. Nat Med. 1996 May;2(5):574-7. doi: 10.1038/nm0596-574. Nat Med. 1996. PMID: 8616718
Cell death sensitization of leukemia cells by opioid receptor activation.
Friesen C, Roscher M, Hormann I, Fichtner I, Alt A, Hilger RA, Debatin KM, Miltner E. Friesen C, et al. Oncotarget. 2013 May;4(5):677-90. doi: 10.18632/oncotarget.952. Oncotarget. 2013. PMID: 23633472 Free PMC article.
Methadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance.
Friesen C, Roscher M, Alt A, Miltner E. Friesen C, et al. Cancer Res. 2008 Aug 1;68(15):6059-64. doi: 10.1158/0008-5472.CAN-08-1227. Cancer Res. 2008. PMID: 18676827
DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.
Friesen C, Uhl M, Pannicke U, Schwarz K, Miltner E, Debatin KM. Friesen C, et al. Mol Biol Cell. 2008 Aug;19(8):3283-9. doi: 10.1091/mbc.e08-03-0306. Epub 2008 May 28. Mol Biol Cell. 2008. PMID: 18508926 Free PMC article.
123I-ITdU-mediated nanoirradiation of DNA efficiently induces cell kill in HL60 leukemia cells and in doxorubicin-, beta-, or gamma-radiation-resistant cell lines.
Reske SN, Deisenhofer S, Glatting G, Zlatopolskiy BD, Morgenroth A, Vogg AT, Buck AK, Friesen C. Reske SN, et al. Among authors: friesen c. J Nucl Med. 2007 Jun;48(6):1000-7. doi: 10.2967/jnumed.107.040337. Epub 2007 May 15. J Nucl Med. 2007. PMID: 17504875
Breaking chemoresistance and radioresistance with [213Bi]anti-CD45 antibodies in leukemia cells.
Friesen C, Glatting G, Koop B, Schwarz K, Morgenstern A, Apostolidis C, Debatin KM, Reske SN. Friesen C, et al. Cancer Res. 2007 Mar 1;67(5):1950-8. doi: 10.1158/0008-5472.CAN-06-3569. Cancer Res. 2007. PMID: 17332322
Natural killer resistance of a drug-resistant leukemia cell line, mediated by up-regulation of HLA class I expression.
Classen CF, Falk CS, Friesen C, Fulda S, Herr I, Debatin KM. Classen CF, et al. Among authors: friesen c. Haematologica. 2003 May;88(5):509-21. Haematologica. 2003. PMID: 12745270
Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells.
Friesen C, Lubatschofski A, Kotzerke J, Buchmann I, Reske SN, Debatin KM. Friesen C, et al. Eur J Nucl Med Mol Imaging. 2003 Sep;30(9):1251-61. doi: 10.1007/s00259-003-1216-z. Epub 2003 Jun 26. Eur J Nucl Med Mol Imaging. 2003. PMID: 12830326
Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma.
Friesen C, Hormann I, Roscher M, Fichtner I, Alt A, Hilger R, Debatin KM, Miltner E. Friesen C, et al. Cell Cycle. 2014;13(10):1560-70. doi: 10.4161/cc.28493. Epub 2014 Mar 12. Cell Cycle. 2014. PMID: 24626197 Free PMC article.
A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells.
Friesen C, Kiess Y, Debatin KM. Friesen C, et al. Cell Death Differ. 2004 Jul;11 Suppl 1:S73-85. doi: 10.1038/sj.cdd.4401431. Cell Death Differ. 2004. PMID: 15105835
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