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Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?
Bisson J, McAlpine JB, Friesen JB, Chen SN, Graham J, Pauli GF. Bisson J, et al. Among authors: friesen jb. J Med Chem. 2016 Mar 10;59(5):1671-90. doi: 10.1021/acs.jmedchem.5b01009. Epub 2015 Oct 27. J Med Chem. 2016. PMID: 26505758 Free PMC article. Review.
An experimental implementation of chemical subtraction.
Chen SN, Turner A, Jaki BU, Nikolic D, van Breemen RB, Friesen JB, Pauli GF. Chen SN, et al. Among authors: friesen jb. J Pharm Biomed Anal. 2008 Mar 13;46(4):692-8. doi: 10.1016/j.jpba.2007.12.014. Epub 2007 Dec 17. J Pharm Biomed Anal. 2008. PMID: 18234463 Free PMC article.
Countercurrent separation of natural products.
Pauli GF, Pro SM, Friesen JB. Pauli GF, et al. Among authors: friesen jb. J Nat Prod. 2008 Aug;71(8):1489-508. doi: 10.1021/np800144q. Epub 2008 Jul 31. J Nat Prod. 2008. PMID: 18666799 Review.
58 results