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Physiologic evaluation of 4 weeks of nocturnal nasal positive pressure ventilation in stable hypercapnic patients with chronic obstructive pulmonary disease.
Nava S, Fanfulla F, Frigerio P, Navalesi P. Nava S, et al. Among authors: frigerio p. Respiration. 2001;68(6):573-83. doi: 10.1159/000050575. Respiration. 2001. PMID: 11786711

RESULTS: By the end of the 4 weeks NIMV had induced a slight but significant (p < 0.01) reduction in resting PaCO(2) (53.78 +/- 5.64 mm Hg) associated with a decrease in the pressure time product of the diaphragm per minute (from 172 +/- 60 to 136 +/- 61 cm H(2)O/l/s;

RESULTS: By the end of the 4 weeks NIMV had induced a slight but significant (p < 0.01) reduction in resting PaCO(2) (53.78 +/- 5.

Physiologic evaluation of noninvasive mechanical ventilation delivered with three types of masks in patients with chronic hypercapnic respiratory failure.
Navalesi P, Fanfulla F, Frigerio P, Gregoretti C, Nava S. Navalesi P, et al. Among authors: frigerio p. Crit Care Med. 2000 Jun;28(6):1785-90. doi: 10.1097/00003246-200006000-00015. Crit Care Med. 2000. PMID: 10890620 Clinical Trial.

Overall, a nasal mask was better tolerated than the other two interfaces (p < .005 vs. nasal plugs and full-face mask). PaCO2 was significantly lower (p < .01) with a full-face mask or nasal plugs than with a nasal mask (49.5 +/- 9.4 torr, 49.7 +/- 8 torr, and

Overall, a nasal mask was better tolerated than the other two interfaces (p < .005 vs. nasal plugs and full-face mask). PaCO2 was

Evaluation of patient skin breakdown and comfort with a new face mask for non-invasive ventilation: a multi-center study.
Gregoretti C, Confalonieri M, Navalesi P, Squadrone V, Frigerio P, Beltrame F, Carbone G, Conti G, Gamna F, Nava S, Calderini E, Skrobik Y, Antonelli M. Gregoretti C, et al. Among authors: frigerio p. Intensive Care Med. 2002 Mar;28(3):278-84. doi: 10.1007/s00134-002-1208-7. Epub 2002 Feb 6. Intensive Care Med. 2002. PMID: 11904656 Clinical Trial.
Skin breakdown was significantly higher in the CMs group over the study period ( p<0.001). Patient comfort was higher in the PM group after 24 and 48 h ( p=0.008 and p<0.001, respectively). ...Eye irritation was slightly higher in the PM versus CMs grou …
Skin breakdown was significantly higher in the CMs group over the study period ( p<0.001). Patient comfort was higher in the PM gr …
Noninvasive vs invasive ventilation in COPD patients with severe acute respiratory failure deemed to require ventilatory assistance.
Squadrone E, Frigerio P, Fogliati C, Gregoretti C, Conti G, Antonelli M, Costa R, Baiardi P, Navalesi P. Squadrone E, et al. Among authors: frigerio p. Intensive Care Med. 2004 Jul;30(7):1303-10. doi: 10.1007/s00134-004-2320-7. Epub 2004 Jun 12. Intensive Care Med. 2004. PMID: 15197438 Clinical Trial.
The NIV group had fewer complications ( P = 0.01) and showed a trend toward a lower proportion of patients remaining on mechanical ventilation after 30 days ( P = 0.056). ...
The NIV group had fewer complications ( P = 0.01) and showed a trend toward a lower proportion of patients remaining on mechanical ve …
Chest physiotherapy improves lung aeration in hypersecretive critically ill patients: a pilot randomized physiological study.
Longhini F, Bruni A, Garofalo E, Ronco C, Gusmano A, Cammarota G, Pasin L, Frigerio P, Chiumello D, Navalesi P. Longhini F, et al. Among authors: frigerio p. Crit Care. 2020 Aug 3;24(1):479. doi: 10.1186/s13054-020-03198-6. Crit Care. 2020. PMID: 32746877 Free PMC article. Clinical Trial.
Rate of reintubation in mechanically ventilated neurosurgical and neurologic patients: evaluation of a systematic approach to weaning and extubation.
Navalesi P, Frigerio P, Moretti MP, Sommariva M, Vesconi S, Baiardi P, Levati A. Navalesi P, et al. Among authors: frigerio p. Crit Care Med. 2008 Nov;36(11):2986-92. doi: 10.1097/CCM.0b013e31818b35f2. Crit Care Med. 2008. PMID: 18824909 Clinical Trial.
MAIN RESULTS: The rate of reintubation was lower in the intervention (5%) than in the control (12.5%) group (p = 0.047). There was no difference in any of the other outcome variables (secondary end points). Simplified Acute Physiologic Score II (adjusted odds ratio 1.042 p …
MAIN RESULTS: The rate of reintubation was lower in the intervention (5%) than in the control (12.5%) group (p = 0.047). There was no …
Prolonged weaning: from the intensive care unit to home.
Navalesi P, Frigerio P, Patzlaff A, Häußermann S, Henseke P, Kubitschek M. Navalesi P, et al. Among authors: frigerio p. Rev Port Pneumol. 2014 Sep-Oct;20(5):264-72. doi: 10.1016/j.rppneu.2014.04.006. Epub 2014 Jun 26. Rev Port Pneumol. 2014. PMID: 24975297 Review.
Bench Comparative Assessment of Mechanically Assisted Cough Devices.
Frigerio P, Longhini F, Sommariva M, Stagni EG, Curto F, Redaelli T, Ciboldi M, Simonds AK, Navalesi P. Frigerio P, et al. Respir Care. 2015 Jul;60(7):975-82. doi: 10.4187/respcare.03809. Epub 2015 May 5. Respir Care. 2015. PMID: 25944939
Evaluation of a systematic approach to weaning of tracheotomized neurological patients: an early interrupted randomized controlled trial.
Vaschetto R, Frigerio P, Sommariva M, Boggero A, Rondi V, Grossi F, Cavuto S, Nava S, Corte FD, Navalesi P. Vaschetto R, et al. Among authors: frigerio p. Ann Intensive Care. 2015 Dec;5(1):54. doi: 10.1186/s13613-015-0098-0. Epub 2015 Dec 23. Ann Intensive Care. 2015. PMID: 26698596 Free PMC article.
Twenty-one patients (24 %) in the intervention group and 27 (33 %) controls were reconnected to the ventilator within 48 h (p = 0.222). ...
Twenty-one patients (24 %) in the intervention group and 27 (33 %) controls were reconnected to the ventilator within 48 h (p = 0.222 …
Sleep apnea and periodic leg movements in the first year after spinal cord injury.
Proserpio P, Lanza A, Sambusida K, Fratticci L, Frigerio P, Sommariva M, Stagni EG, Redaelli T, De Carli F, Nobili L. Proserpio P, et al. Among authors: frigerio p. Sleep Med. 2015 Jan;16(1):59-66. doi: 10.1016/j.sleep.2014.07.019. Epub 2014 Oct 7. Sleep Med. 2015. PMID: 25454844
The frequency of SDB was higher in tetraplegic with respect to paraplegic patients (Wald statistic: 7.71; P = 0.0055), whereas PLMs were significantly more frequent in patients with an incomplete motor lesion than in subjects with a complete motor lesion (Wald statistic: 6 …
The frequency of SDB was higher in tetraplegic with respect to paraplegic patients (Wald statistic: 7.71; P = 0.0055), whereas PLMs w …
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