Frimurer TM - Search Results

1

Molecular mechanism of 7TM receptor activation--a global toggle switch model.

Schwartz TW, Frimurer TM, Holst B, Rosenkilde MM, Elling CE. Schwartz TW, et al. Among authors: frimurer tm. Annu Rev Pharmacol Toxicol. 2006;46:481-519. doi: 10.1146/annurev.pharmtox.46.120604.141218. Annu Rev Pharmacol Toxicol. 2006. PMID: 16402913 Review.

2

Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119.

Engelstoft MS, Norn C, Hauge M, Holliday ND, Elster L, Lehmann J, Jones RM, Frimurer TM, Schwartz TW. Engelstoft MS, et al. Among authors: frimurer tm. Br J Pharmacol. 2014 Dec;171(24):5774-89. doi: 10.1111/bph.12877. Br J Pharmacol. 2014. PMID: 25117266 Free PMC article.

3

Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2.

Jensen PC, Thiele S, Steen A, Elder A, Kolbeck R, Ghosh S, Frimurer TM, Rosenkilde MM. Jensen PC, et al. Among authors: frimurer tm. Br J Pharmacol. 2012 May;166(1):258-75. doi: 10.1111/j.1476-5381.2011.01771.x. Br J Pharmacol. 2012. PMID: 22050085 Free PMC article.

4

Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5).

Steen A, Sparre-Ulrich AH, Thiele S, Guo D, Frimurer TM, Rosenkilde MM. Steen A, et al. Among authors: frimurer tm. Br J Pharmacol. 2014 Mar;171(6):1566-79. doi: 10.1111/bph.12553. Br J Pharmacol. 2014. PMID: 24328926 Free PMC article.

5

Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5).

Karlshøj S, Amarandi RM, Larsen O, Daugvilaite V, Steen A, Brvar M, Pui A, Frimurer TM, Ulven T, Rosenkilde MM. Karlshøj S, et al. Among authors: frimurer tm. J Biol Chem. 2016 Dec 23;291(52):26860-26874. doi: 10.1074/jbc.M116.740183. Epub 2016 Nov 10. J Biol Chem. 2016. PMID: 27834679 Free PMC article.

6

Biased agonism and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus-induced gene 2.

Daugvilaite V, Madsen CM, Lückmann M, Echeverria CC, Sailer AW, Frimurer TM, Rosenkilde MM, Benned-Jensen T. Daugvilaite V, et al. Among authors: frimurer tm. Br J Pharmacol. 2017 Jul;174(13):2031-2042. doi: 10.1111/bph.13801. Epub 2017 May 4. Br J Pharmacol. 2017. PMID: 28369721 Free PMC article.

7

Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183).

Benned-Jensen T, Norn C, Laurent S, Madsen CM, Larsen HM, Arfelt KN, Wolf RM, Frimurer T, Sailer AW, Rosenkilde MM. Benned-Jensen T, et al. J Biol Chem. 2012 Oct 12;287(42):35470-35483. doi: 10.1074/jbc.M112.387894. Epub 2012 Aug 8. J Biol Chem. 2012. PMID: 22875855 Free PMC article.

8

Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism.

Holst B, Mokrosinski J, Lang M, Brandt E, Nygaard R, Frimurer TM, Beck-Sickinger AG, Schwartz TW. Holst B, et al. Among authors: frimurer tm. J Biol Chem. 2007 May 25;282(21):15799-811. doi: 10.1074/jbc.M609796200. Epub 2007 Mar 19. J Biol Chem. 2007. PMID: 17371869

9

Biased Gs versus Gq proteins and β-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network.

Valentin-Hansen L, Frimurer TM, Mokrosinski J, Holliday ND, Schwartz TW. Valentin-Hansen L, et al. Among authors: frimurer tm. J Biol Chem. 2015 Oct 2;290(40):24495-508. doi: 10.1074/jbc.M115.641944. Epub 2015 Aug 12. J Biol Chem. 2015. PMID: 26269596 Free PMC article.

10

Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7.

Steen A, Thiele S, Guo D, Hansen LS, Frimurer TM, Rosenkilde MM. Steen A, et al. Among authors: frimurer tm. J Biol Chem. 2013 May 3;288(18):12511-21. doi: 10.1074/jbc.M112.449587. Epub 2013 Mar 14. J Biol Chem. 2013. PMID: 23493400 Free PMC article.

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