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Effect of the pattern of elevated free fatty acids on insulin sensitivity and insulin secretion in healthy humans.
Stefan N, Wahl HG, Fritsche A, Häring H, Stumvoll M. Stefan N, et al. Among authors: fritsche a. Horm Metab Res. 2001 Jul;33(7):432-8. doi: 10.1055/s-2001-16231. Horm Metab Res. 2001. PMID: 11507682 Clinical Trial.
A hyperglycemic clamp (approx. 8 mM, 140 min) was performed before and 5 and 24 hours after both lipid infusions to determine insulin sensitivity and insulin secretion simultaneously. ...
A hyperglycemic clamp (approx. 8 mM, 140 min) was performed before and 5 and 24 hours after both lipid infusions to determine insulin
Effect of hypoglycemia on beta-adrenergic sensitivity in normal and type 1 diabetic subjects.
Fritsche A, Stumvoll M, Grüb M, Sieslack S, Renn W, Schmülling RM, Häring HU, Gerich JE. Fritsche A, et al. Diabetes Care. 1998 Sep;21(9):1505-10. doi: 10.2337/diacare.21.9.1505. Diabetes Care. 1998. PMID: 9727899
Beta-adrenergic sensitivity was measured with the isoproterenol test after a hyperinsulinemic euglycemic clamp and after a hyperinsulinemic hypoglycemic clamp. ...A unifying hypothesis is presented for the pathogenesis of hypoglycemia unawareness in type 1 di …
Beta-adrenergic sensitivity was measured with the isoproterenol test after a hyperinsulinemic euglycemic clamp and after a hyp …
Evidence for inhibition of leptin secretion by catecholamines in man.
Fritsche A, Wahl HG, Metzinger E, Renn W, Kellerer M, Häring H, Stumvoll M. Fritsche A, et al. Exp Clin Endocrinol Diabetes. 1998;106(5):415-8. doi: 10.1055/s-0029-1212008. Exp Clin Endocrinol Diabetes. 1998. PMID: 9831308
Leptin concentrations were determined during both a euglycemic and hypoglycemic hyperinsulinemic clamp study in 10 normal and 10 type I diabetic subjects. ...In conclusion our results indicate that catecholamines play a suppressive role in the regulation of leptin s …
Leptin concentrations were determined during both a euglycemic and hypoglycemic hyperinsulinemic clamp study in 10 normal and 10 type …
Leptin levels in humans are acutely suppressed by isoproterenol despite acipimox-induced inhibition of lipolysis, but not by free fatty acids.
Stumvoll M, Fritsche A, Tschritter O, Lehmann R, Wahl HG, Renn W, Häring H. Stumvoll M, et al. Among authors: fritsche a. Metabolism. 2000 Mar;49(3):335-9. doi: 10.1016/s0026-0495(00)90198-7. Metabolism. 2000. PMID: 10726911
To dissect differential effects on leptin secretion, we performed two experimental protocols in 11 lean healthy subjects in addition to a saline infusion plus oral acipimox to suppress lipolysis (SAL + ACX) as a control experiment: (1) isoproterenol (approximately 3 …
To dissect differential effects on leptin secretion, we performed two experimental protocols in 11 lean healthy subjects in addition to a
A novel hyperglycaemic clamp for characterization of islet function in humans: assessment of three different secretagogues, maximal insulin response and reproducibility.
Fritsche A, Stefan N, Hardt E, Schützenauer S, Häring H, Stumvoll M. Fritsche A, et al. Eur J Clin Invest. 2000 May;30(5):411-8. doi: 10.1046/j.1365-2362.2000.00649.x. Eur J Clin Invest. 2000. PMID: 10809901 Clinical Trial.
MATERIALS AND METHODS: We designed a novel test assessing plasma insulin and C-peptide in response to 3 different secretagogues. ...On a third occasion 6 subjects additionally received an arginine bolus at > 25 mM blood glucose, a test hitherto claimed to …
MATERIALS AND METHODS: We designed a novel test assessing plasma insulin and C-peptide in response to 3 different secretagogues. ...O …
A 60 minute hyperglycemic clamp is sufficient to assess both phases of insulin secretion.
Stumvoll M, Fritsche A, Stefan N, Häring H. Stumvoll M, et al. Among authors: fritsche a. Horm Metab Res. 2000 Jun;32(6):230-2. doi: 10.1055/s-2007-978626. Horm Metab Res. 2000. PMID: 10898552
In order to achieve a reasonable insulin plateau for the second phase, it has become common practice to clamp for 120 or even 180 minutes at 10 mM. ...In conclusion, a one-hour hyperglycemic clamp can provide the standard measurement of first phase insulin secretion …
In order to achieve a reasonable insulin plateau for the second phase, it has become common practice to clamp for 120 or even 180 min …
Intensive insulin therapy combined with metformin in obese type 2 diabetic patients.
Fritsche A, Schmülling RM, Häring HU, Stumvoll M. Fritsche A, et al. Acta Diabetol. 2000 Mar;37(1):13-8. doi: 10.1007/s005920070030. Acta Diabetol. 2000. PMID: 10928231 Clinical Trial.
Patients were randomly assigned to either metformin or placebo treatment (double-blind) for 10 weeks and after a 2 week washout period received the opposite treatment, respectively, for 10 additional weeks. ...With respect to glycemia and lipids, adjunct metformin can be …
Patients were randomly assigned to either metformin or placebo treatment (double-blind) for 10 weeks and after a 2 week washout perio …
Characterisation of beta-cell dysfunction of impaired glucose tolerance: evidence for impairment of incretin-induced insulin secretion.
Fritsche A, Stefan N, Hardt E, Häring H, Stumvoll M. Fritsche A, et al. Diabetologia. 2000 Jul;43(7):852-8. doi: 10.1007/s001250051461. Diabetologia. 2000. PMID: 10952457
A modified hyperglycaemic clamp (10 mmol/1) with a standard 2-h square-wave hyperglycaemia, an additional glucagon-like-peptide (GLP)-1 phase (1.5 pmol x kg(-1) x min(-1) over 80 min) and a final arginine bolus (5 g) was used to assess various phases of insul
A modified hyperglycaemic clamp (10 mmol/1) with a standard 2-h square-wave hyperglycaemia, an additional glucagon-like-peptid
Stimulatory effect of increased non-esterified fatty acid concentrations on proinsulin processing in healthy humans.
Stefan N, Fritsche A, Madaus A, Häring H, Stumvoll M. Stefan N, et al. Among authors: fritsche a. Diabetologia. 2000 Nov;43(11):1368-73. doi: 10.1007/s001250051540. Diabetologia. 2000. PMID: 11126404
METHODS: We did a hyperglycaemic clamp (130 min duration, 8 mmol/l glucose, with a 5-g arginine bolus at min 120) before and after a 5-h infusion of Intralipid/heparin in 14 healthy subjects. Of the subjects eight underwent a saline control experiment. …
METHODS: We did a hyperglycaemic clamp (130 min duration, 8 mmol/l glucose, with a 5-g arginine bolus at min 120) before and a …
Evidence against a rate-limiting role of proinsulin processing for maximal insulin secretion in subjects with impaired glucose tolerance and beta-cell dysfunction.
Stumvoll M, Fritsche A, Stefan N, Hardt E, Häring H. Stumvoll M, et al. Among authors: fritsche a. J Clin Endocrinol Metab. 2001 Mar;86(3):1235-9. doi: 10.1210/jcem.86.3.7331. J Clin Endocrinol Metab. 2001. PMID: 11238514
This strongly argues against the hypothesis that defective processing of proinsulin to insulin represents a major component of the beta-cell dysfunction in IGT....
This strongly argues against the hypothesis that defective processing of proinsulin to insulin represents a major component of the be …
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