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Glimepiride combined with morning insulin glargine, bedtime neutral protamine hagedorn insulin, or bedtime insulin glargine in patients with type 2 diabetes. A randomized, controlled trial.
Fritsche A, Schweitzer MA, Häring HU; 4001 Study Group. Fritsche A, et al. Ann Intern Med. 2003 Jun 17;138(12):952-9. doi: 10.7326/0003-4819-138-12-200306170-00006. Ann Intern Med. 2003. PMID: 12809451 Clinical Trial.
The insulin dose was titrated by using a predefined regimen to achieve fasting blood glucose levels of 5.56 mmol/L or lower (< or =100 mg/dL). MEASUREMENTS: Hemoglobin A(1c) values, blood glucose levels, insulin dose, and body weight. RESULTS: Hemoglobin A
The insulin dose was titrated by using a predefined regimen to achieve fasting blood glucose levels of 5.56 mmol/L or lower (< or …
Necrotizing fasciitis caused by unencapsulated Haemophilus influenzae.
Stumvoll M, Fritsche A. Stumvoll M, et al. Among authors: fritsche a. Clin Infect Dis. 1997 Aug;25(2):327. doi: 10.1086/516908. Clin Infect Dis. 1997. PMID: 9332536 No abstract available.
Diabetes teaching program improves glycemic control and preserves perception of hypoglycemia.
Fritsche A, Stumvoll M, Renn W, Schmülling RM. Fritsche A, et al. Diabetes Res Clin Pract. 1998 May;40(2):129-35. doi: 10.1016/s0168-8227(98)00047-3. Diabetes Res Clin Pract. 1998. PMID: 9681278

Group H had a lower overall accuracy of BG estimation (P = 0.048) and a lower overall sensitivity for detecting BG levels < 3.9 mmol/l (P = 0.03) than group N. ...On the contrary, patients with a history of severe hypoglycemia improved their awareness of B

Group H had a lower overall accuracy of BG estimation (P = 0.048) and a lower overall sensitivity for detecting BG levels < …
Effect of hypoglycemia on beta-adrenergic sensitivity in normal and type 1 diabetic subjects.
Fritsche A, Stumvoll M, Grüb M, Sieslack S, Renn W, Schmülling RM, Häring HU, Gerich JE. Fritsche A, et al. Diabetes Care. 1998 Sep;21(9):1505-10. doi: 10.2337/diacare.21.9.1505. Diabetes Care. 1998. PMID: 9727899
Beta-adrenergic sensitivity was measured with the isoproterenol test after a hyperinsulinemic euglycemic clamp and after a hyperinsulinemic hypoglycemic clamp. ...A unifying hypothesis is presented for the pathogenesis of hypoglycemia unawareness in type 1 di …
Beta-adrenergic sensitivity was measured with the isoproterenol test after a hyperinsulinemic euglycemic clamp and after a hyp …
Evidence for inhibition of leptin secretion by catecholamines in man.
Fritsche A, Wahl HG, Metzinger E, Renn W, Kellerer M, Häring H, Stumvoll M. Fritsche A, et al. Exp Clin Endocrinol Diabetes. 1998;106(5):415-8. doi: 10.1055/s-0029-1212008. Exp Clin Endocrinol Diabetes. 1998. PMID: 9831308
Leptin concentrations were determined during both a euglycemic and hypoglycemic hyperinsulinemic clamp study in 10 normal and 10 type I diabetic subjects. ...In conclusion our results indicate that catecholamines play a suppressive role in the regulation of leptin s …
Leptin concentrations were determined during both a euglycemic and hypoglycemic hyperinsulinemic clamp study in 10 normal and 10 type …
Long term effect of a structured inpatient diabetes teaching and treatment programme in type 2 diabetic patients: influence of mode of follow-up.
Fritsche A, Stumvoll M, Goebbel S, Reinauer KM, Schmülling RM, Häring HU. Fritsche A, et al. Diabetes Res Clin Pract. 1999 Nov;46(2):135-41. doi: 10.1016/s0168-8227(99)00081-9. Diabetes Res Clin Pract. 1999. PMID: 10724092
In addition, differences in the mode of follow-up by a university diabetes centre (UDC) versus general practitioner (GP) were assessed. ...Patients had a significantly better knowledge of diabetes and diet 2 years after the programme. For all parameters tested, none …
In addition, differences in the mode of follow-up by a university diabetes centre (UDC) versus general practitioner (GP) were assesse …
Leptin levels in humans are acutely suppressed by isoproterenol despite acipimox-induced inhibition of lipolysis, but not by free fatty acids.
Stumvoll M, Fritsche A, Tschritter O, Lehmann R, Wahl HG, Renn W, Häring H. Stumvoll M, et al. Among authors: fritsche a. Metabolism. 2000 Mar;49(3):335-9. doi: 10.1016/s0026-0495(00)90198-7. Metabolism. 2000. PMID: 10726911
To dissect differential effects on leptin secretion, we performed two experimental protocols in 11 lean healthy subjects in addition to a saline infusion plus oral acipimox to suppress lipolysis (SAL + ACX) as a control experiment: (1) isoproterenol (approximately 3 …
To dissect differential effects on leptin secretion, we performed two experimental protocols in 11 lean healthy subjects in addition to a
A novel hyperglycaemic clamp for characterization of islet function in humans: assessment of three different secretagogues, maximal insulin response and reproducibility.
Fritsche A, Stefan N, Hardt E, Schützenauer S, Häring H, Stumvoll M. Fritsche A, et al. Eur J Clin Invest. 2000 May;30(5):411-8. doi: 10.1046/j.1365-2362.2000.00649.x. Eur J Clin Invest. 2000. PMID: 10809901 Clinical Trial.
MATERIALS AND METHODS: We designed a novel test assessing plasma insulin and C-peptide in response to 3 different secretagogues. ...On a third occasion 6 subjects additionally received an arginine bolus at > 25 mM blood glucose, a test hitherto claimed to …
MATERIALS AND METHODS: We designed a novel test assessing plasma insulin and C-peptide in response to 3 different secretagogues. ...O …
A 60 minute hyperglycemic clamp is sufficient to assess both phases of insulin secretion.
Stumvoll M, Fritsche A, Stefan N, Häring H. Stumvoll M, et al. Among authors: fritsche a. Horm Metab Res. 2000 Jun;32(6):230-2. doi: 10.1055/s-2007-978626. Horm Metab Res. 2000. PMID: 10898552
In order to achieve a reasonable insulin plateau for the second phase, it has become common practice to clamp for 120 or even 180 minutes at 10 mM. ...In conclusion, a one-hour hyperglycemic clamp can provide the standard measurement of first phase insulin secretion …
In order to achieve a reasonable insulin plateau for the second phase, it has become common practice to clamp for 120 or even 180 min …
Intensive insulin therapy combined with metformin in obese type 2 diabetic patients.
Fritsche A, Schmülling RM, Häring HU, Stumvoll M. Fritsche A, et al. Acta Diabetol. 2000 Mar;37(1):13-8. doi: 10.1007/s005920070030. Acta Diabetol. 2000. PMID: 10928231 Clinical Trial.
Patients were randomly assigned to either metformin or placebo treatment (double-blind) for 10 weeks and after a 2 week washout period received the opposite treatment, respectively, for 10 additional weeks. ...With respect to glycemia and lipids, adjunct metformin can be …
Patients were randomly assigned to either metformin or placebo treatment (double-blind) for 10 weeks and after a 2 week washout perio …
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