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8-Prenyl naringenin is a potent ERalpha selective phytoestrogen present in hops and beer.
Schaefer O, Hümpel M, Fritzemeier KH, Bohlmann R, Schleuning WD. Schaefer O, et al. J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):359-60. doi: 10.1016/s0960-0760(03)00050-5. J Steroid Biochem Mol Biol. 2003. PMID: 12711023 No abstract available.
Effects of estradiol, estrogen receptor subtype-selective agonists and genistein on glucose metabolism in leptin resistant female Zucker diabetic fatty (ZDF) rats.
Weigt C, Hertrampf T, Flenker U, Hülsemann F, Kurnaz P, Fritzemeier KH, Diel P. Weigt C, et al. Among authors: fritzemeier kh. J Steroid Biochem Mol Biol. 2015 Nov;154:12-22. doi: 10.1016/j.jsbmb.2015.06.002. Epub 2015 Jun 29. J Steroid Biochem Mol Biol. 2015. PMID: 26134426
Dissecting physiological roles of estrogen receptor alpha and beta with potent selective ligands from structure-based design.
Hillisch A, Peters O, Kosemund D, Müller G, Walter A, Schneider B, Reddersen G, Elger W, Fritzemeier KH. Hillisch A, et al. Mol Endocrinol. 2004 Jul;18(7):1599-609. doi: 10.1210/me.2004-0050. Epub 2004 Apr 22. Mol Endocrinol. 2004. PMID: 15105439
In vivo characterization of estrogen receptor modulators with reduced genomic versus nongenomic activity in vitro.
Otto C, Fuchs I, Altmann H, Klewer M, Schwarz G, Bohlmann R, Nguyen D, Zorn L, Vonk R, Prelle K, Osterman T, Malmström C, Fritzemeier KH. Otto C, et al. J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):95-100. doi: 10.1016/j.jsbmb.2008.05.003. Epub 2008 Jul 7. J Steroid Biochem Mol Biol. 2008. PMID: 18606537
Identification of estrogen receptor ligands leading to activation of non-genomic signaling pathways while exhibiting only weak transcriptional activity.
Wessler S, Otto C, Wilck N, Stangl V, Fritzemeier KH. Wessler S, et al. J Steroid Biochem Mol Biol. 2006 Jan;98(1):25-35. doi: 10.1016/j.jsbmb.2005.08.003. Epub 2005 Oct 3. J Steroid Biochem Mol Biol. 2006. PMID: 16203130
Impact of isotype-selective estrogen receptor agonists on ovarian function.
Hegele-Hartung C, Siebel P, Peters O, Kosemund D, Müller G, Hillisch A, Walter A, Kraetzschmar J, Fritzemeier KH. Hegele-Hartung C, et al. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5129-34. doi: 10.1073/pnas.0306720101. Epub 2004 Mar 22. Proc Natl Acad Sci U S A. 2004. PMID: 15037755 Free PMC article.
GPR30 does not mediate estrogenic responses in reproductive organs in mice.
Otto C, Fuchs I, Kauselmann G, Kern H, Zevnik B, Andreasen P, Schwarz G, Altmann H, Klewer M, Schoor M, Vonk R, Fritzemeier KH. Otto C, et al. Biol Reprod. 2009 Jan;80(1):34-41. doi: 10.1095/biolreprod.108.071175. Epub 2008 Sep 17. Biol Reprod. 2009. PMID: 18799753
Protein-structure-based prediction of animal model suitability for pharmacodynamic studies of subtype-selective estrogens.
Toschi L, Hilbig J, Wintermantel T, Engelhaupt A, Walter A, Fritzemeier KH, Hillisch A. Toschi L, et al. ChemMedChem. 2006 Nov;1(11):1237-48. doi: 10.1002/cmdc.200600183. ChemMedChem. 2006. PMID: 17001712
G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol.
Otto C, Rohde-Schulz B, Schwarz G, Fuchs I, Klewer M, Brittain D, Langer G, Bader B, Prelle K, Nubbemeyer R, Fritzemeier KH. Otto C, et al. Endocrinology. 2008 Oct;149(10):4846-56. doi: 10.1210/en.2008-0269. Epub 2008 Jun 19. Endocrinology. 2008. PMID: 18566127
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