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Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.
Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Teichman SL, et al. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. J Clin Endocrinol Metab. 2006. PMID: 16352683 Clinical Trial.
Octreotide as primary therapy for acromegaly.
Newman CB, Melmed S, George A, Torigian D, Duhaney M, Snyder P, Young W, Klibanski A, Molitch ME, Gagel R, Sheeler L, Cook D, Malarkey W, Jackson I, Vance ML, Barkan A, Frohman L, Kleinberg DL. Newman CB, et al. J Clin Endocrinol Metab. 1998 Sep;83(9):3034-40. doi: 10.1210/jcem.83.9.5109. J Clin Endocrinol Metab. 1998. PMID: 9745397 Clinical Trial.
Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.
Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ. Sackmann-Sala L, et al. Among authors: frohman la. Growth Horm IGF Res. 2009 Dec;19(6):471-7. doi: 10.1016/j.ghir.2009.03.001. Epub 2009 Apr 21. Growth Horm IGF Res. 2009. PMID: 19386527 Free PMC article.
Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.
Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Alba M, et al. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. doi: 10.1152/ajpendo.00201.2006. Epub 2006 Jul 5. Am J Physiol Endocrinol Metab. 2006. PMID: 16822960
A subcutaneous octreotide hydrogel implant for the treatment of acromegaly.
Gadelha MR, Chieffo C, Bai SA, Hu X, Frohman LA. Gadelha MR, et al. Among authors: frohman la. Endocr Pract. 2012 Nov-Dec;18(6):870-81. doi: 10.4158/EP11388.OR. Endocr Pract. 2012. PMID: 22784835 Clinical Trial.
Efficacy and safety of an octreotide implant in the treatment of patients with acromegaly.
Chieffo C, Cook D, Xiang Q, Frohman LA. Chieffo C, et al. Among authors: frohman la. J Clin Endocrinol Metab. 2013 Oct;98(10):4047-54. doi: 10.1210/jc.2013-2262. Epub 2013 Aug 22. J Clin Endocrinol Metab. 2013. PMID: 23969184 Clinical Trial.
Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.
Ionescu M, Frohman LA. Ionescu M, et al. J Clin Endocrinol Metab. 2006 Dec;91(12):4792-7. doi: 10.1210/jc.2006-1702. Epub 2006 Oct 3. J Clin Endocrinol Metab. 2006. PMID: 17018654 Clinical Trial.
Tumor deletion mapping on chromosome 11q13 in eight families with isolated familial somatotropinoma and in 15 sporadic somatotropinomas.
Soares BS, Eguchi K, Frohman LA. Soares BS, et al. J Clin Endocrinol Metab. 2005 Dec;90(12):6580-7. doi: 10.1210/jc.2005-1478. Epub 2005 Sep 27. J Clin Endocrinol Metab. 2005. PMID: 16189251
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