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Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent.
Aminkeng F, Ross CJ, Rassekh SR, Brunham LR, Sistonen J, Dube MP, Ibrahim M, Nyambo TB, Omar SA, Froment A, Bodo JM, Tishkoff S, Carleton BC, Hayden MR; Canadian Pharmacogenomics Network for Drug Safety Consortium. Aminkeng F, et al. Among authors: froment a. Pharmacogenomics J. 2014 Apr;14(2):160-70. doi: 10.1038/tpj.2013.13. Epub 2013 Apr 16. Pharmacogenomics J. 2014. PMID: 23588107 Free PMC article.
Effects of natural selection and gene conversion on the evolution of human glycophorins coding for MNS blood polymorphisms in malaria-endemic African populations.
Ko WY, Kaercher KA, Giombini E, Marcatili P, Froment A, Ibrahim M, Lema G, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA. Ko WY, et al. Among authors: froment a. Am J Hum Genet. 2011 Jun 10;88(6):741-754. doi: 10.1016/j.ajhg.2011.05.005. Am J Hum Genet. 2011. PMID: 21664997 Free PMC article.
Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Rucker JB, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA. Campbell MC, et al. Among authors: froment a. Mol Biol Evol. 2014 Feb;31(2):288-302. doi: 10.1093/molbev/mst211. Epub 2013 Oct 30. Mol Biol Evol. 2014. PMID: 24177185 Free PMC article.
Genetic origins of lactase persistence and the spread of pastoralism in Africa.
Ranciaro A, Campbell MC, Hirbo JB, Ko WY, Froment A, Anagnostou P, Kotze MJ, Ibrahim M, Nyambo T, Omar SA, Tishkoff SA. Ranciaro A, et al. Among authors: froment a. Am J Hum Genet. 2014 Apr 3;94(4):496-510. doi: 10.1016/j.ajhg.2014.02.009. Epub 2014 Mar 13. Am J Hum Genet. 2014. PMID: 24630847 Free PMC article.
Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa.
Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo J, Thompson S, Woldemeskel D, Froment A, Omar SA, Bodo JM, Nyambo T, Belay G, Drayna D, Breslin PA, Tishkoff SA. Campbell MC, et al. Among authors: froment a. J Hum Genet. 2014 Jun;59(6):349-52. doi: 10.1038/jhg.2014.29. Epub 2014 May 1. J Hum Genet. 2014. PMID: 24785689 Free PMC article.
197 results