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Characterization of beta-adrenoceptor antagonists as substrates and inhibitors of the drug transporter P-glycoprotein.
Bachmakov I, Werner U, Endress B, Auge D, Fromm MF. Bachmakov I, et al. Among authors: fromm mf. Fundam Clin Pharmacol. 2006 Jun;20(3):273-82. doi: 10.1111/j.1472-8206.2006.00408.x. Fundam Clin Pharmacol. 2006. PMID: 16671962
Shed human enterocytes as a tool for the study of expression and function of intestinal drug-metabolizing enzymes and transporters.
Glaeser H, Drescher S, van der Kuip H, Behrens C, Geick A, Burk O, Dent J, Somogyi A, Von Richter O, Griese EU, Eichelbaum M, Fromm MF. Glaeser H, et al. Among authors: fromm mf. Clin Pharmacol Ther. 2002 Mar;71(3):131-40. doi: 10.1067/mcp.2002.121370. Clin Pharmacol Ther. 2002. PMID: 11907487 Clinical Trial.
MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.
Drescher S, Schaeffeler E, Hitzl M, Hofmann U, Schwab M, Brinkmann U, Eichelbaum M, Fromm MF. Drescher S, et al. Among authors: fromm mf. Br J Clin Pharmacol. 2002 May;53(5):526-34. doi: 10.1046/j.1365-2125.2002.01591.x. Br J Clin Pharmacol. 2002. PMID: 11994059 Free PMC article. Clinical Trial.
Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.
Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF. Bhardwaj RK, et al. Among authors: fromm mf. J Pharmacol Exp Ther. 2002 Aug;302(2):645-50. doi: 10.1124/jpet.102.034728. J Pharmacol Exp Ther. 2002. PMID: 12130727
Genetic polymorphisms of the human MDR1 drug transporter.
Schwab M, Eichelbaum M, Fromm MF. Schwab M, et al. Among authors: fromm mf. Annu Rev Pharmacol Toxicol. 2003;43:285-307. doi: 10.1146/annurev.pharmtox.43.100901.140233. Epub 2002 Jan 10. Annu Rev Pharmacol Toxicol. 2003. PMID: 12359865 Review.
The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans.
Fromm MF. Fromm MF. Adv Drug Deliv Rev. 2002 Nov 18;54(10):1295-310. doi: 10.1016/s0169-409x(02)00064-9. Adv Drug Deliv Rev. 2002. PMID: 12406646 Review.
Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene.
Johne A, Köpke K, Gerloff T, Mai I, Rietbrock S, Meisel C, Hoffmeyer S, Kerb R, Fromm MF, Brinkmann U, Eichelbaum M, Brockmöller J, Cascorbi I, Roots I. Johne A, et al. Among authors: fromm mf. Clin Pharmacol Ther. 2002 Nov;72(5):584-94. doi: 10.1067/mcp.2002.129196. Clin Pharmacol Ther. 2002. PMID: 12426522
Genetically determined differences in P-glycoprotein function: implications for disease risk.
Fromm MF. Fromm MF. Toxicology. 2002 Dec 27;181-182:299-303. doi: 10.1016/s0300-483x(02)00297-4. Toxicology. 2002. PMID: 12505329 Review.
Influence of omeprazole on multidrug resistance protein 3 expression in human liver.
Hitzl M, Klein K, Zanger UM, Fritz P, Nüssler AK, Neuhaus P, Fromm MF. Hitzl M, et al. Among authors: fromm mf. J Pharmacol Exp Ther. 2003 Feb;304(2):524-30. doi: 10.1124/jpet.102.043547. J Pharmacol Exp Ther. 2003. PMID: 12538803
P-glycoprotein-mediated intestinal and biliary digoxin transport in humans.
Drescher S, Glaeser H, Mürdter T, Hitzl M, Eichelbaum M, Fromm MF. Drescher S, et al. Among authors: fromm mf. Clin Pharmacol Ther. 2003 Mar;73(3):223-31. doi: 10.1067/mcp.2003.27. Clin Pharmacol Ther. 2003. PMID: 12621387
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