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Targeted delivery of lopinavir to HIV reservoirs in the mesenteric lymphatic system by lipophilic ester prodrug approach.
Qin C, Chu Y, Feng W, Fromont C, He S, Ali J, Lee JB, Zgair A, Berton M, Bettonte S, Liu R, Yang L, Monmaturapoj T, Medrano-Padial C, Ugalde AAR, Vetrugno D, Ee SY, Sheriston C, Wu Y, Stocks MJ, Fischer PM, Gershkovich P. Qin C, et al. Among authors: fromont c. J Control Release. 2021 Jan 10;329:1077-1089. doi: 10.1016/j.jconrel.2020.10.036. Epub 2020 Oct 20. J Control Release. 2021. PMID: 33091528
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini GP, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaya V, Morgan J, Sorrell FJ, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers SP, Cheetham SC, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S. Fromont C, et al. J Med Chem. 2020 Jul 9;63(13):6784-6801. doi: 10.1021/acs.jmedchem.9b01803. Epub 2020 Jun 22. J Med Chem. 2020. PMID: 32433887 Free PMC article.
Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Zyryanova AF, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ, Ron D. Zyryanova AF, et al. Among authors: fromont c. Science. 2018 Mar 30;359(6383):1533-1536. doi: 10.1126/science.aar5129. Science. 2018. PMID: 29599245 Free PMC article.
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