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The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.
Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. Slaughter A, et al. Among authors: fuchs jr. Retrovirology. 2014 Nov 25;11:100. doi: 10.1186/s12977-014-0100-1. Retrovirology. 2014. PMID: 25421939 Free PMC article.
Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.
Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M. Kessl JJ, et al. Among authors: fuchs jr. J Biol Chem. 2012 May 11;287(20):16801-11. doi: 10.1074/jbc.M112.354373. Epub 2012 Mar 21. J Biol Chem. 2012. PMID: 22437836 Free PMC article.
HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.
Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH, Engelman A. Wang H, et al. Among authors: fuchs jr. Nucleic Acids Res. 2012 Dec;40(22):11518-30. doi: 10.1093/nar/gks913. Epub 2012 Oct 5. Nucleic Acids Res. 2012. PMID: 23042676 Free PMC article.
Bioactive flavaglines and other constituents isolated from Aglaia perviridis.
Pan L, Acuña UM, Li J, Jena N, Ninh TN, Pannell CM, Chai H, Fuchs JR, Carcache de Blanco EJ, Soejarto DD, Kinghorn AD. Pan L, et al. Among authors: fuchs jr. J Nat Prod. 2013 Mar 22;76(3):394-404. doi: 10.1021/np3007588. Epub 2013 Jan 9. J Nat Prod. 2013. PMID: 23301897 Free PMC article.
The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. Feng L, et al. Among authors: fuchs jr. J Biol Chem. 2013 May 31;288(22):15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24. J Biol Chem. 2013. PMID: 23615903 Free PMC article.
A new class of multimerization selective inhibitors of HIV-1 integrase.
Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. Sharma A, et al. Among authors: fuchs jr. PLoS Pathog. 2014 May 29;10(5):e1004171. doi: 10.1371/journal.ppat.1004171. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24874515 Free PMC article.
149 results