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Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding.
Fabbretti A, Schedlbauer A, Brandi L, Kaminishi T, Giuliodori AM, Garofalo R, Ochoa-Lizarralde B, Takemoto C, Yokoyama S, Connell SR, Gualerzi CO, Fucini P. Fabbretti A, et al. Among authors: fucini p. Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2286-95. doi: 10.1073/pnas.1521156113. Epub 2016 Apr 6. Proc Natl Acad Sci U S A. 2016. PMID: 27071098 Free PMC article.
A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit.
Schedlbauer A, Iturrioz I, Ochoa-Lizarralde B, Diercks T, López-Alonso JP, Lavin JL, Kaminishi T, Çapuni R, Dhimole N, de Astigarraga E, Gil-Carton D, Fucini P, Connell SR. Schedlbauer A, et al. Among authors: fucini p. Sci Adv. 2021 Jun 4;7(23):eabf7547. doi: 10.1126/sciadv.abf7547. Print 2021 Jun. Sci Adv. 2021. PMID: 34088665 Free PMC article.
RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket.
López-Alonso JP, Kaminishi T, Kikuchi T, Hirata Y, Iturrioz I, Dhimole N, Schedlbauer A, Hase Y, Goto S, Kurita D, Muto A, Zhou S, Naoe C, Mills DJ, Gil-Carton D, Takemoto C, Himeno H, Fucini P, Connell SR. López-Alonso JP, et al. Among authors: fucini p. Nucleic Acids Res. 2017 Jun 20;45(11):6945-6959. doi: 10.1093/nar/gkx324. Nucleic Acids Res. 2017. PMID: 28482099 Free PMC article.
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