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A two-in-one antibody engineered from a humanized interleukin 4 antibody through mutation in heavy chain complementarity-determining regions.
Lee CV, Koenig P, Fuh G. Lee CV, et al. Among authors: fuh g. MAbs. 2014 May-Jun;6(3):622-7. doi: 10.4161/mabs.28483. Epub 2014 Mar 11. MAbs. 2014. PMID: 24618680 Free PMC article.
The molecular basis for growth hormone-receptor interactions.
Wells JA, Cunningham BC, Fuh G, Lowman HB, Bass SH, Mulkerrin MG, Ultsch M, deVos AM. Wells JA, et al. Among authors: fuh g. Recent Prog Horm Res. 1993;48:253-75. Recent Prog Horm Res. 1993. PMID: 8441850 Review.
Recently, based upon this proposed mechanism, we produced potent antagonists to the hGH receptor (Fuh et al., 1992) and hPRL receptor (G. Fuh, P. Colosi, W. Wood, and J. ...
Recently, based upon this proposed mechanism, we produced potent antagonists to the hGH receptor (Fuh et al., 1992) and hPRL receptor …
Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity.
Pearce KH Jr, Cunningham BC, Fuh G, Teeri T, Wells JA. Pearce KH Jr, et al. Among authors: fuh g. Biochemistry. 1999 Jan 5;38(1):81-9. doi: 10.1021/bi9817008. Biochemistry. 1999. PMID: 9890885
Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
Chen Y, Wiesmann C, Fuh G, Li B, Christinger HW, McKay P, de Vos AM, Lowman HB. Chen Y, et al. Among authors: fuh g. J Mol Biol. 1999 Nov 5;293(4):865-81. doi: 10.1006/jmbi.1999.3192. J Mol Biol. 1999. PMID: 10543973
Analysis of PDZ domain-ligand interactions using carboxyl-terminal phage display.
Fuh G, Pisabarro MT, Li Y, Quan C, Lasky LA, Sidhu SS. Fuh G, et al. J Biol Chem. 2000 Jul 14;275(28):21486-91. doi: 10.1074/jbc.275.28.21486. J Biol Chem. 2000. PMID: 10887205
Bivalent antibody phage display mimics natural immunoglobulin.
Lee CV, Sidhu SS, Fuh G. Lee CV, et al. Among authors: fuh g. J Immunol Methods. 2004 Jan;284(1-2):119-32. doi: 10.1016/j.jim.2003.11.001. J Immunol Methods. 2004. PMID: 14736422
Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions.
Sidhu SS, Li B, Chen Y, Fellouse FA, Eigenbrot C, Fuh G. Sidhu SS, et al. Among authors: fuh g. J Mol Biol. 2004 Apr 23;338(2):299-310. doi: 10.1016/j.jmb.2004.02.050. J Mol Biol. 2004. PMID: 15066433
High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold.
Lee CV, Liang WC, Dennis MS, Eigenbrot C, Sidhu SS, Fuh G. Lee CV, et al. Among authors: fuh g. J Mol Biol. 2004 Jul 23;340(5):1073-93. doi: 10.1016/j.jmb.2004.05.051. J Mol Biol. 2004. PMID: 15236968
Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF.
Liang WC, Wu X, Peale FV, Lee CV, Meng YG, Gutierrez J, Fu L, Malik AK, Gerber HP, Ferrara N, Fuh G. Liang WC, et al. Among authors: fuh g. J Biol Chem. 2006 Jan 13;281(2):951-61. doi: 10.1074/jbc.M508199200. Epub 2005 Nov 7. J Biol Chem. 2006. PMID: 16278208
Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
Fuh G, Wu P, Liang WC, Ultsch M, Lee CV, Moffat B, Wiesmann C. Fuh G, et al. J Biol Chem. 2006 Mar 10;281(10):6625-31. doi: 10.1074/jbc.M507783200. Epub 2005 Dec 22. J Biol Chem. 2006. PMID: 16373345
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