Fuhrer W - Search Results

1

Nonpeptidic angiotensin II antagonists: synthesis and in vitro activity of a series of novel naphthalene and tetrahydronaphthalene derivatives.

Bühlmayer P, Criscione L, Fuhrer W, Furet P, de Gasparo M, Stutz S, Whitebread S. Bühlmayer P, et al. Among authors: fuhrer w. J Med Chem. 1991 Oct;34(10):3105-14. doi: 10.1021/jm00114a021. J Med Chem. 1991. PMID: 1920360

2

Synthesis and biological activity of some transition-state inhibitors of human renin.

Bühlmayer P, Caselli A, Fuhrer W, Göschke R, Rasetti V, Rüeger H, Stanton JL, Criscione L, Wood JM. Bühlmayer P, et al. Among authors: fuhrer w. J Med Chem. 1988 Sep;31(9):1839-46. doi: 10.1021/jm00117a027. J Med Chem. 1988. PMID: 3137345

3

Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin.

Göschke R, Stutz S, Rasetti V, Cohen NC, Rahuel J, Rigollier P, Baum HP, Forgiarini P, Schnell CR, Wagner T, Gruetter MG, Fuhrer W, Schilling W, Cumin F, Wood JM, Maibaum J. Göschke R, et al. Among authors: fuhrer w. J Med Chem. 2007 Oct 4;50(20):4818-31. doi: 10.1021/jm070314y. Epub 2007 Sep 8. J Med Chem. 2007. PMID: 17824679

4

5-Methyl-6-phenyl-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazocine-2,4-dione (BA 41899): representative of a novel class of purely calcium-sensitizing agents.

Herold P, Herzig JW, Wenk P, Leutert T, Zbinden P, Fuhrer W, Stutz S, Schenker K, Meier M, Rihs G. Herold P, et al. Among authors: fuhrer w. J Med Chem. 1995 Jul 21;38(15):2946-54. doi: 10.1021/jm00015a017. J Med Chem. 1995. PMID: 7636855

5

Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets.

Maibaum J, Stutz S, Göschke R, Rigollier P, Yamaguchi Y, Cumin F, Rahuel J, Baum HP, Cohen NC, Schnell CR, Fuhrer W, Gruetter MG, Schilling W, Wood JM. Maibaum J, et al. Among authors: fuhrer w. J Med Chem. 2007 Oct 4;50(20):4832-44. doi: 10.1021/jm070316i. Epub 2007 Sep 8. J Med Chem. 2007. PMID: 17824680

6

Renin inhibitors. Synthesis of transition-state analogue inhibitors containing phosphorus acid derivatives at the scissile bond.

Allen MC, Fuhrer W, Tuck B, Wade R, Wood JM. Allen MC, et al. Among authors: fuhrer w. J Med Chem. 1989 Jul;32(7):1652-61. doi: 10.1021/jm00127a041. J Med Chem. 1989. PMID: 2661820

7

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin.

Rahuel J, Rasetti V, Maibaum J, Rüeger H, Göschke R, Cohen NC, Stutz S, Cumin F, Fuhrer W, Wood JM, Grütter MG. Rahuel J, et al. Among authors: fuhrer w. Chem Biol. 2000 Jul;7(7):493-504. doi: 10.1016/s1074-5521(00)00134-4. Chem Biol. 2000. PMID: 10903938

8

Structure-based design of aliskiren, a novel orally effective renin inhibitor.

Wood JM, Maibaum J, Rahuel J, Grütter MG, Cohen NC, Rasetti V, Rüger H, Göschke R, Stutz S, Fuhrer W, Schilling W, Rigollier P, Yamaguchi Y, Cumin F, Baum HP, Schnell CR, Herold P, Mah R, Jensen C, O'Brien E, Stanton A, Bedigian MP. Wood JM, et al. Among authors: fuhrer w. Biochem Biophys Res Commun. 2003 Sep 5;308(4):698-705. doi: 10.1016/s0006-291x(03)01451-7. Biochem Biophys Res Commun. 2003. PMID: 12927775

9

Beta-adrenergic blocking agents: substituted phenylalkanolamines. Effect of side-chain length on beta-blocking potency in vitro.

Fuhrer W, Ostermayer F, Zimmermann M, Meier M, Müller H. Fuhrer W, et al. J Med Chem. 1984 Jul;27(7):831-6. doi: 10.1021/jm00373a003. J Med Chem. 1984. PMID: 6145802

10

CGP 22979A, a renal vasodilator with natriuretic properties.

Hofbauer KG, Sonnenburg C, Stalder R, Criscione L, Kraetz J, Fuhrer W, Habicht E. Hofbauer KG, et al. Among authors: fuhrer w. J Pharmacol Exp Ther. 1985 Mar;232(3):838-44. J Pharmacol Exp Ther. 1985. PMID: 3973831

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