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Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method
Li L, et al. Cancer Gene Ther 2010. Among authors: Fujisaki H. PMID 19745843 Free PMC article.
Transfection of eGFP mRNA into ex vivo expanded NK cells (N=5) or purified unstimulated NK cells from peripheral blood (N=4) resulted in good cell viability with eGFP expression in 85+/-6% and 86+/-4%, 24 h after transfection, respectively. ...The target-specific cytotoxicity for anti-CD19-BB-z mRNA-transfected NK cells was observed as early as 3 h after transfection and persisted for up to 3 days. ...
Transfection of eGFP mRNA into ex vivo expanded NK cells (N=5) or purified unstimulated NK cells from peripheral blood (N=4) resulted in goo …
A clinically adaptable method to enhance the cytotoxicity of natural killer cells against B-cell malignancies
Shimasaki N, et al. Cytotherapy 2012. Among authors: Fujisaki H. PMID 22458956
Receptor expression was detectable 6 h after electroporation, reaching maximum levels at 24-48 h; specific anti-CD19 cytotoxicity was observed at 96 h. ...Median receptor expression after 24 h was 82.0%; NK cells transfected under these conditions exerted considerable cytotoxicity in xenograft models of B-cell leukemia. ...
Receptor expression was detectable 6 h after electroporation, reaching maximum levels at 24-48 h; specific anti-CD19 cytotoxic …
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