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1,778 results
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ASK family proteins in stress response and disease.
Fujisawa T, Takeda K, Ichijo H. Fujisawa T, et al. Mol Biotechnol. 2007 Sep;37(1):13-8. doi: 10.1007/s12033-007-0053-x. Mol Biotechnol. 2007. PMID: 17914158 Review.
SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.
Homma K, Fujisawa T, Tsuburaya N, Yamaguchi N, Kadowaki H, Takeda K, Nishitoh H, Matsuzawa A, Naguro I, Ichijo H. Homma K, et al. Among authors: fujisawa t. Mol Cell. 2013 Oct 10;52(1):75-86. doi: 10.1016/j.molcel.2013.08.038. Epub 2013 Sep 26. Mol Cell. 2013. PMID: 24076220
The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.
Fujisawa T, Takahashi M, Tsukamoto Y, Yamaguchi N, Nakoji M, Endo M, Kodaira H, Hayashi Y, Nishitoh H, Naguro I, Homma K, Ichijo H. Fujisawa T, et al. Hum Mol Genet. 2016 Jan 15;25(2):245-53. doi: 10.1093/hmg/ddv467. Epub 2015 Nov 24. Hum Mol Genet. 2016. PMID: 26604152
Therapeutic application of apoptosis signal-regulating kinase 1 inhibitors.
Fujisawa T. Fujisawa T. Adv Biol Regul. 2017 Dec;66:85-90. doi: 10.1016/j.jbior.2017.10.004. Epub 2017 Oct 16. Adv Biol Regul. 2017. PMID: 29066277 Review.
The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1.
Sugawara S, Kanamaru Y, Sekine S, Maekawa L, Takahashi A, Yamamoto T, Watanabe K, Fujisawa T, Hattori K, Ichijo H. Sugawara S, et al. Among authors: fujisawa t. J Biol Chem. 2020 Apr 24;295(17):5588-5601. doi: 10.1074/jbc.RA119.011508. Epub 2020 Mar 6. J Biol Chem. 2020. PMID: 32144202
Apoptosis signal-regulating kinase 1 (ASK1) as a therapeutic target for neurological diseases.
Takenaka S, Fujisawa T, Ichijo H. Takenaka S, et al. Among authors: fujisawa t. Expert Opin Ther Targets. 2020 Nov;24(11):1061-1064. doi: 10.1080/14728222.2020.1821648. Epub 2020 Sep 30. Expert Opin Ther Targets. 2020. PMID: 32930624 No abstract available.
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.
Fujisawa T, Homma K, Yamaguchi N, Kadowaki H, Tsuburaya N, Naguro I, Matsuzawa A, Takeda K, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Ichijo H. Fujisawa T, et al. Ann Neurol. 2012 Nov;72(5):739-49. doi: 10.1002/ana.23668. Ann Neurol. 2012. PMID: 23280792
[ASK1-MAP kinase signaling pathway as a therapeutic target for human diseases].
Fujisawa T, Ichijo H. Fujisawa T, et al. Nihon Rinsho. 2014 May;72(5):957-65. Nihon Rinsho. 2014. PMID: 24912301 Review. Japanese.
A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.
Fujisawa T, Yamaguchi N, Kadowaki H, Tsukamoto Y, Tsuburaya N, Tsubota A, Takahashi H, Naguro I, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Homma K, Ichijo H. Fujisawa T, et al. Neurobiol Dis. 2015 Oct;82:478-486. doi: 10.1016/j.nbd.2015.08.010. Epub 2015 Aug 18. Neurobiol Dis. 2015. PMID: 26297318
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.
Tsuburaya N, Homma K, Higuchi T, Balia A, Yamakoshi H, Shibata N, Nakamura S, Nakagawa H, Ikeda SI, Umezawa N, Kato N, Yokoshima S, Shibuya M, Shimonishi M, Kojima H, Okabe T, Nagano T, Naguro I, Imamura K, Inoue H, Fujisawa T, Ichijo H. Tsuburaya N, et al. Among authors: fujisawa t. Nat Commun. 2018 Jul 10;9(1):2668. doi: 10.1038/s41467-018-05127-2. Nat Commun. 2018. PMID: 29991716 Free PMC article.
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