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Induction of metallothionein by manganese is completely dependent on interleukin-6 production.
Kobayashi K, Kuroda J, Shibata N, Hasegawa T, Seko Y, Satoh M, Tohyama C, Takano H, Imura N, Sakabe K, Fujishiro H, Himeno S. Kobayashi K, et al. Among authors: Fujishiro H. J Pharmacol Exp Ther. 2007 Feb;320(2):721-7. doi: 10.1124/jpet.106.112912. Epub 2006 Oct 25. J Pharmacol Exp Ther. 2007. PMID: 17065364
Subsequently, serum levels of serum amyloid A (SAA), an acute-phase protein induced by IL-6, increased with a peak at 24 h. However, no increase in serum alanine aminotransferase activity was observed, suggesting that manganese enhanced the production of IL-6 and SAA without causing liver injury. ...
Subsequently, serum levels of serum amyloid A (SAA), an acute-phase protein induced by IL-6, increased with a peak at 24 h. However, …
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