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Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound.
Okoye AA, Hansen SG, Vaidya M, Fukazawa Y, Park H, Duell DM, Lum R, Hughes CM, Ventura AB, Ainslie E, Ford JC, Morrow D, Gilbride RM, Legasse AW, Hesselgesser J, Geleziunas R, Li Y, Oswald K, Shoemaker R, Fast R, Bosche WJ, Borate BR, Edlefsen PT, Axthelm MK, Picker LJ, Lifson JD. Okoye AA, et al. Among authors: fukazawa y. Nat Med. 2018 Sep;24(9):1430-1440. doi: 10.1038/s41591-018-0130-7. Epub 2018 Aug 6. Nat Med. 2018. PMID: 30082858 Free PMC article.
Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines.
Fukazawa Y, Park H, Cameron MJ, Lefebvre F, Lum R, Coombes N, Mahyari E, Hagen SI, Bae JY, Reyes MD 3rd, Swanson T, Legasse AW, Sylwester A, Hansen SG, Smith AT, Stafova P, Shoemaker R, Li Y, Oswald K, Axthelm MK, McDermott A, Ferrari G, Montefiori DC, Edlefsen PT, Piatak M Jr, Lifson JD, Sékaly RP, Picker LJ. Fukazawa Y, et al. Nat Med. 2012 Nov;18(11):1673-81. doi: 10.1038/nm.2934. Epub 2012 Sep 9. Nat Med. 2012. PMID: 22961108 Free PMC article.
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers.
Fukazawa Y, Lum R, Okoye AA, Park H, Matsuda K, Bae JY, Hagen SI, Shoemaker R, Deleage C, Lucero C, Morcock D, Swanson T, Legasse AW, Axthelm MK, Hesselgesser J, Geleziunas R, Hirsch VM, Edlefsen PT, Piatak M Jr, Estes JD, Lifson JD, Picker LJ. Fukazawa Y, et al. Nat Med. 2015 Feb;21(2):132-9. doi: 10.1038/nm.3781. Epub 2015 Jan 19. Nat Med. 2015. PMID: 25599132 Free PMC article.
Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques.
Okoye AA, DeGottardi MQ, Fukazawa Y, Vaidya M, Abana CO, Konfe AL, Fachko DN, Duell DM, Li H, Lum R, Gao L, Park BS, Skalsky RL, Lewis AD, Axthelm MK, Lifson JD, Wong SW, Picker LJ. Okoye AA, et al. Among authors: fukazawa y. J Immunol. 2019 Dec 1;203(11):2928-2943. doi: 10.4049/jimmunol.1900792. Epub 2019 Oct 25. J Immunol. 2019. PMID: 31653683 Free PMC article.
CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification.
Okoye AA, Duell DD, Fukazawa Y, Varco-Merth B, Marenco A, Behrens H, Chaunzwa M, Selseth AN, Gilbride RM, Shao J, Edlefsen PT, Geleziunas R, Pinkevych M, Davenport MP, Busman-Sahay K, Nekorchuk M, Park H, Smedley J, Axthelm MK, Estes JD, Hansen SG, Keele BF, Lifson JD, Picker LJ. Okoye AA, et al. Among authors: fukazawa y. J Clin Invest. 2021 Apr 15;131(8):e141677. doi: 10.1172/JCI141677. J Clin Invest. 2021. PMID: 33630764 Free PMC article.
Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy.
Barrenäs F, Hansen SG, Law L, Driscoll C, Green RR, Smith E, Chang J, Golez I, Urion T, Peng X, Whitmore L, Newhouse D, Hughes CM, Morrow D, Randall KT, Selseth AN, Ford JC, Gilbride RM, Randall BE, Ainslie E, Oswald K, Shoemaker R, Fast R, Bosche WJ, Axthelm MK, Fukazawa Y, Pavlakis GN, Felber BK, Fourati S, Sekaly RP, Lifson JD, Komorowski J, Kosmider E, Shao D, Song W, Edlefsen PT, Picker LJ, Gale M Jr. Barrenäs F, et al. Among authors: fukazawa y. PLoS Pathog. 2021 Jul 6;17(7):e1009278. doi: 10.1371/journal.ppat.1009278. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34228762 Free PMC article.
Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques.
Haeseleer F, Fukazawa Y, Park H, Varco-Merth B, Rust BJ, Smedley JV, Eichholz K, Peterson CW, Mason R, Kiem HP, Roederer M, Picker LJ, Okoye AA, Corey L. Haeseleer F, et al. Among authors: fukazawa y. Mol Ther Methods Clin Dev. 2021 Jun 24;22:304-319. doi: 10.1016/j.omtm.2021.06.008. eCollection 2021 Sep 10. Mol Ther Methods Clin Dev. 2021. PMID: 34485613 Free PMC article.
The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription.
Okoye AA, Fromentin R, Takata H, Brehm JH, Fukazawa Y, Randall B, Pardons M, Tai V, Tang J, Smedley J, Axthelm M, Lifson JD, Picker LJ, Favre D, Trautmann L, Chomont N. Okoye AA, et al. Among authors: fukazawa y. PLoS Pathog. 2022 Jan 18;18(1):e1010245. doi: 10.1371/journal.ppat.1010245. eCollection 2022 Jan. PLoS Pathog. 2022. PMID: 35041707 Free PMC article.
Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy.
Varco-Merth BD, Brantley W, Marenco A, Duell DD, Fachko DN, Richardson B, Busman-Sahay K, Shao D, Flores W, Engelman K, Fukazawa Y, Wong SW, Skalsky RL, Smedley J, Axthelm MK, Lifson JD, Estes JD, Edlefsen PT, Picker LJ, Cameron CM, Henrich TJ, Okoye AA. Varco-Merth BD, et al. Among authors: fukazawa y. J Clin Invest. 2022 May 16;132(10):e156063. doi: 10.1172/JCI156063. J Clin Invest. 2022. PMID: 35316218 Free PMC article.
351 results