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Functional genomic analysis of peripheral blood during early acute renal allograft rejection.
Günther OP, Balshaw RF, Scherer A, Hollander Z, Mui A, Triche TJ, Freue GC, Li G, Ng RT, Wilson-McManus J, McMaster WR, McManus BM, Keown PA; Biomarkers in Transplantation Team. Günther OP, et al. Transplantation. 2009 Oct 15;88(7):942-51. doi: 10.1097/TP.0b013e3181b7ccc6. Transplantation. 2009. PMID: 19935467
BACKGROUND: Acute graft rejection is an important clinical problem in renal transplantation and an adverse predictor for long-term graft survival. Peripheral blood biomarkers that provide evidence of early graft rejection ma …
BACKGROUND: Acute graft rejection is an important clinical problem in renal transplantation and an adverse predi …
New developments in transplant proteomics.
Ho J, Hirt-Minkowski P, Wilkins JA. Ho J, et al. Curr Opin Nephrol Hypertens. 2017 May;26(3):229-234. doi: 10.1097/MNH.0000000000000319. Curr Opin Nephrol Hypertens. 2017. PMID: 28221173 Review.
PURPOSE OF REVIEW: Despite modern immunosuppression, renal allograft rejection remains a major contributor to graft loss. ...Finally, an in-depth exploration of peripheral blood mononuclear cells identified differential proteoform expression in …
PURPOSE OF REVIEW: Despite modern immunosuppression, renal allograft rejection remains a major contributor to graft los …
Pretransplant transcriptomic signature in peripheral blood predicts early acute rejection.
Zhang W, Yi Z, Wei C, Keung KL, Sun Z, Xi C, Woytovich C, Farouk S, Gallon L, Menon MC, Magee C, Najafian N, Samaniego MD, Djamali A, Alexander SI, Rosales IA, Smith RN, O'Connell PJ, Colvin R, Cravedi P, Murphy B. Zhang W, et al. JCI Insight. 2019 Jun 6;4(11):e127543. doi: 10.1172/jci.insight.127543. eCollection 2019 Jun 6. JCI Insight. 2019. PMID: 31167967 Free PMC article.
Commonly available clinical parameters fail to predict early acute cellular rejection (EAR, occurring within 6 months after transplant), a major risk factor for graft loss after kidney transplantation. We performed whole-blood RNA sequencing at …
Commonly available clinical parameters fail to predict early acute cellular rejection (EAR, occurring within 6 months a …
Effects of sample timing and treatment on gene expression in early acute renal allograft rejection.
Günther OP, Lin D, Balshaw RF, Ng RT, Hollander Z, Wilson-McManus J, McMaster WR, McManus BM, Keown PA; Biomarkers in Transplantation Team. Günther OP, et al. Transplantation. 2011 Feb 15;91(3):323-9. doi: 10.1097/TP.0b013e3182029b16. Transplantation. 2011. PMID: 21107303
BACKGROUND: We have shown that genomic biomarkers in peripheral blood provide evidence of early graft rejection and may offer an important option for posttransplant monitoring, and we are working to improve this signature to maximize assay perfo …
BACKGROUND: We have shown that genomic biomarkers in peripheral blood provide evidence of early graft rejecti