Funk C - Search Results

1

New strategies to address drug-drug interactions involving OATPs.

Poirier A, Funk C, Lavé T, Noé J. Poirier A, et al. Among authors: funk c. Curr Opin Drug Discov Devel. 2007 Jan;10(1):74-83. Curr Opin Drug Discov Devel. 2007. PMID: 17265745 Review.

2

Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat.

Funk C, Ponelle C, Scheuermann G, Pantze M. Funk C, et al. Mol Pharmacol. 2001 Mar;59(3):627-35. Mol Pharmacol. 2001. PMID: 11179459

3

Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate.

Funk C, Pantze M, Jehle L, Ponelle C, Scheuermann G, Lazendic M, Gasser R. Funk C, et al. Toxicology. 2001 Oct 5;167(1):83-98. doi: 10.1016/s0300-483x(01)00460-7. Toxicology. 2001. PMID: 11557132

4

Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

Noé J, Portmann R, Brun ME, Funk C. Noé J, et al. Among authors: funk c. Drug Metab Dispos. 2007 Aug;35(8):1308-14. doi: 10.1124/dmd.106.012930. Epub 2007 Apr 30. Drug Metab Dispos. 2007. PMID: 17470528

5

The role of hepatic transporters in drug elimination.

Funk C. Funk C. Expert Opin Drug Metab Toxicol. 2008 Apr;4(4):363-79. doi: 10.1517/17425255.4.4.363. Expert Opin Drug Metab Toxicol. 2008. PMID: 18433342 Review.

6

Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model.

Poirier A, Lavé T, Portmann R, Brun ME, Senner F, Kansy M, Grimm HP, Funk C. Poirier A, et al. Among authors: funk c. Drug Metab Dispos. 2008 Dec;36(12):2434-44. doi: 10.1124/dmd.108.020750. Epub 2008 Sep 22. Drug Metab Dispos. 2008. PMID: 18809732

7

Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system.

Hoffmann G, Funk C, Fowler S, Otteneder MB, Breidenbach A, Rayner CR, Chu T, Prinssen EP. Hoffmann G, et al. Among authors: funk c. Antimicrob Agents Chemother. 2009 Nov;53(11):4753-61. doi: 10.1128/AAC.01541-08. Epub 2009 Aug 31. Antimicrob Agents Chemother. 2009. PMID: 19721074 Free PMC article.

8

Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine.

Poirier A, Funk C, Scherrmann JM, Lavé T. Poirier A, et al. Among authors: funk c. Mol Pharm. 2009 Nov-Dec;6(6):1716-33. doi: 10.1021/mp8002495. Mol Pharm. 2009. PMID: 19739673

9

Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data.

Poirier A, Cascais AC, Funk C, Lavé T. Poirier A, et al. Among authors: funk c. J Pharmacokinet Pharmacodyn. 2009 Dec;36(6):585-611. doi: 10.1007/s10928-009-9139-3. Epub 2009 Nov 20. J Pharmacokinet Pharmacodyn. 2009. PMID: 19936896

10

Prediction of pharmacokinetic profile of valsartan in humans based on in vitro uptake-transport data.

Poirier A, Cascais AC, Funk C, Lavé T. Poirier A, et al. Among authors: funk c. Chem Biodivers. 2009 Nov;6(11):1975-87. doi: 10.1002/cbdv.200900116. Chem Biodivers. 2009. PMID: 19937834

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