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Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.
Furuta M, Carroll R, Martin S, Swift HH, Ravazzola M, Orci L, Steiner DF. Furuta M, et al. J Biol Chem. 1998 Feb 6;273(6):3431-7. doi: 10.1074/jbc.273.6.3431. J Biol Chem. 1998. PMID: 9452465 Free article.
Recently we generated mice lacking active PC2 due to a disruption of the PC2 gene (Furuta, M., Yano, H., Zhou, A., Rouille, Y., Holst, J. J., Carroll, R. J., Ravazzola, M., Orci, L., Furuta, H., and Steiner, D. F. (1997) Proc. Natl. ...
Recently we generated mice lacking active PC2 due to a disruption of the PC2 gene (Furuta, M., Yano, H., Zhou, A., Rouille, Y. …
Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice.
Furuta M, Zhou A, Webb G, Carroll R, Ravazzola M, Orci L, Steiner DF. Furuta M, et al. J Biol Chem. 2001 Jul 20;276(29):27197-202. doi: 10.1074/jbc.M103362200. Epub 2001 May 16. J Biol Chem. 2001. PMID: 11356850 Free article.
Their islets show marked alpha (A)-cell hyperplasia, suggesting a possible defect in glucagon processing (Furuta, M., Yano, H., Zhou, A., Rouille, Y., Holst, J., Carroll, R., Ravazzola, M., Orci, L., Furuta, H., and Steiner, D. (1997) Proc. ...
Their islets show marked alpha (A)-cell hyperplasia, suggesting a possible defect in glucagon processing (Furuta, M., Yano, H. …
725 results