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15 results
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Joint modelling of confounding factors and prominent genetic regulators provides increased accuracy in genetical genomics studies.
Fusi N, Stegle O, Lawrence ND. Fusi N, et al. PLoS Comput Biol. 2012 Jan;8(1):e1002330. doi: 10.1371/journal.pcbi.1002330. Epub 2012 Jan 5. PLoS Comput Biol. 2012. PMID: 22241974 Free PMC article.
Flexible Modeling of Genetic Effects on Function-Valued Traits.
Fusi N, Listgarten J. Fusi N, et al. J Comput Biol. 2017 Jun;24(6):524-535. doi: 10.1089/cmb.2016.0174. Epub 2017 Jan 5. J Comput Biol. 2017. PMID: 28056190
Detecting regulatory gene-environment interactions with unmeasured environmental factors.
Fusi N, Lippert C, Borgwardt K, Lawrence ND, Stegle O. Fusi N, et al. Bioinformatics. 2013 Jun 1;29(11):1382-9. doi: 10.1093/bioinformatics/btt148. Epub 2013 Apr 4. Bioinformatics. 2013. PMID: 23559640
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.
Doench JG, Fusi N, Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten J, Root DE. Doench JG, et al. Among authors: fusi n. Nat Biotechnol. 2016 Feb;34(2):184-191. doi: 10.1038/nbt.3437. Epub 2016 Jan 18. Nat Biotechnol. 2016. PMID: 26780180 Free PMC article.
Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens.
Najm FJ, Strand C, Donovan KF, Hegde M, Sanson KR, Vaimberg EW, Sullender ME, Hartenian E, Kalani Z, Fusi N, Listgarten J, Younger ST, Bernstein BE, Root DE, Doench JG. Najm FJ, et al. Among authors: fusi n. Nat Biotechnol. 2018 Feb;36(2):179-189. doi: 10.1038/nbt.4048. Epub 2017 Dec 18. Nat Biotechnol. 2018. PMID: 29251726 Free PMC article.
Warped linear mixed models for the genetic analysis of transformed phenotypes.
Fusi N, Lippert C, Lawrence ND, Stegle O. Fusi N, et al. Nat Commun. 2014 Sep 19;5:4890. doi: 10.1038/ncomms5890. Nat Commun. 2014. PMID: 25234577 Free PMC article.
Further improvements to linear mixed models for genome-wide association studies.
Widmer C, Lippert C, Weissbrod O, Fusi N, Kadie C, Davidson R, Listgarten J, Heckerman D. Widmer C, et al. Among authors: fusi n. Sci Rep. 2014 Nov 12;4:6874. doi: 10.1038/srep06874. Sci Rep. 2014. PMID: 25387525 Free PMC article.
Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity.
Brockington A, Ning K, Heath PR, Wood E, Kirby J, Fusi N, Lawrence N, Wharton SB, Ince PG, Shaw PJ. Brockington A, et al. Among authors: fusi n. Acta Neuropathol. 2013 Jan;125(1):95-109. doi: 10.1007/s00401-012-1058-5. Epub 2012 Nov 13. Acta Neuropathol. 2013. PMID: 23143228 Free PMC article.
Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs.
Listgarten J, Weinstein M, Kleinstiver BP, Sousa AA, Joung JK, Crawford J, Gao K, Hoang L, Elibol M, Doench JG, Fusi N. Listgarten J, et al. Among authors: fusi n. Nat Biomed Eng. 2018 Jan;2(1):38-47. doi: 10.1038/s41551-017-0178-6. Epub 2018 Jan 10. Nat Biomed Eng. 2018. PMID: 29998038 Free PMC article.
A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control.
Bartha I, Carlson JM, Brumme CJ, McLaren PJ, Brumme ZL, John M, Haas DW, Martinez-Picado J, Dalmau J, López-Galíndez C, Casado C, Rauch A, Günthard HF, Bernasconi E, Vernazza P, Klimkait T, Yerly S, O'Brien SJ, Listgarten J, Pfeifer N, Lippert C, Fusi N, Kutalik Z, Allen TM, Müller V, Harrigan PR, Heckerman D, Telenti A, Fellay J. Bartha I, et al. Among authors: fusi n. Elife. 2013 Oct 29;2:e01123. doi: 10.7554/eLife.01123. Elife. 2013. PMID: 24171102 Free PMC article.
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