Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2008 1
2009 2
2010 2
2011 3
2012 1
2013 4
2014 5
2015 1
2016 3
2017 4
2018 7
2019 3
2021 6
2022 1
2023 4
2024 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

42 results

Results by year

Filters applied: . Clear all
Page 1
Novel enzymology in futalosine-dependent menaquinone biosynthesis.
Joshi S, Fedoseyenko D, Mahanta N, Manion H, Naseem S, Dairi T, Begley TP. Joshi S, et al. Curr Opin Chem Biol. 2018 Dec;47:134-141. doi: 10.1016/j.cbpa.2018.09.015. Epub 2018 Nov 15. Curr Opin Chem Biol. 2018. PMID: 30447488 Review.
The recently discovered futalosine-dependent menaquinone biosynthesis pathway employs radical chemistry for the naphthoquinol core assembly. ...The enzymology of the tailoring reactions after dihydroxynaphthoic acid formation remains to be elucidated. Since the futalosi …
The recently discovered futalosine-dependent menaquinone biosynthesis pathway employs radical chemistry for the naphthoquinol core as …
Inhibition of the futalosine pathway for menaquinone biosynthesis suppresses Chlamydia trachomatis infection.
Dudiak BM, Nguyen TM, Needham D, Outlaw TC, McCafferty DG. Dudiak BM, et al. FEBS Lett. 2021 Dec;595(24):2995-3005. doi: 10.1002/1873-3468.14223. Epub 2021 Nov 16. FEBS Lett. 2021. PMID: 34741525 Free PMC article.
Chlamydia trachomatis, an obligate intracellular bacterium with limited metabolic capabilities, possesses the futalosine pathway for menaquinone biosynthesis. Futalosine pathway enzymes have promise as narrow-spectrum antibiotic targets, but the activity and essenti …
Chlamydia trachomatis, an obligate intracellular bacterium with limited metabolic capabilities, possesses the futalosine pathway for …
Identification of pulvomycin as an inhibitor of the futalosine pathway.
Ogasawara Y, Umetsu S, Inahashi Y, Nonaka K, Dairi T. Ogasawara Y, et al. J Antibiot (Tokyo). 2021 Nov;74(11):825-829. doi: 10.1038/s41429-021-00465-8. Epub 2021 Aug 20. J Antibiot (Tokyo). 2021. PMID: 34417567 Free article.
Menaquinone is biosynthesized from chorismate using either the well-known canonical pathway established by pioneering studies in model microorganisms or the futalosine pathway, which we discovered in Streptomyces. Because Helicobacter pylori, which causes stomach cancer, u …
Menaquinone is biosynthesized from chorismate using either the well-known canonical pathway established by pioneering studies in model micro …
Futalosine and its derivatives, new nucleoside analogs.
Hosokawa N, Naganawa H, Kasahara T, Hattori S, Hamada M, Takeuchi T, Yamamoto S, Tsuchiya KS, Hori M. Hosokawa N, et al. Chem Pharm Bull (Tokyo). 1999 Jul;47(7):1032-4. doi: 10.1248/cpb.47.1032. Chem Pharm Bull (Tokyo). 1999. PMID: 10576935
Futalosine, a new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. Some chemical derivatives of futalosine were prepared. 6-O-Methylfutalosine methylester inhibited growth of HeLa-S3 cells in vitro (IC50 = 19.5 micrograms/ml) …
Futalosine, a new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. Some chemical derivatives …
The futalosine pathway played an important role in menaquinone biosynthesis during early prokaryote evolution.
Zhi XY, Yao JC, Tang SK, Huang Y, Li HW, Li WJ. Zhi XY, et al. Genome Biol Evol. 2014 Jan;6(1):149-60. doi: 10.1093/gbe/evu007. Genome Biol Evol. 2014. PMID: 24398376 Free PMC article.
Although the classical MK pathway was found in 32.1% of the proteomes, more than twice the proportion containing the futalosine pathway, the latter was found in a broader taxonomic range of organisms (18 of 31 phyla). ...Therefore, the organization of the futalosine …
Although the classical MK pathway was found in 32.1% of the proteomes, more than twice the proportion containing the futalosine pathw …
Mechanism of chorismate dehydratase MqnA, the first enzyme of the futalosine pathway, proceeds via substrate-assisted catalysis.
Prasad A, Breithaupt C, Nguyen DA, Lilie H, Ziegler J, Stubbs MT. Prasad A, et al. J Biol Chem. 2022 Dec;298(12):102601. doi: 10.1016/j.jbc.2022.102601. Epub 2022 Oct 18. J Biol Chem. 2022. PMID: 36265588 Free PMC article.
MqnA, the only chorismate dehydratase known so far, catalyzes the initial step in the biosynthesis of menaquinone via the futalosine pathway. Details of the MqnA reaction mechanism remain unclear. Here, we present crystal structures of Streptomyces coelicolor MqnA and its …
MqnA, the only chorismate dehydratase known so far, catalyzes the initial step in the biosynthesis of menaquinone via the futalosine …
Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway.
Shimizu Y, Ogasawara Y, Matsumoto A, Dairi T. Shimizu Y, et al. J Antibiot (Tokyo). 2018 Nov;71(11):968-970. doi: 10.1038/s41429-018-0087-2. Epub 2018 Aug 8. J Antibiot (Tokyo). 2018. PMID: 30089869
We searched for specific inhibitors of the futalosine pathway, non-canonical pathway of menaquinone biosynthesis operating in Helicobacter pylori, from metabolites produced by actinomycetes. ...K15-0223 as a specific inhibitor of the futalosine pathway. We also show …
We searched for specific inhibitors of the futalosine pathway, non-canonical pathway of menaquinone biosynthesis operating in Helicob …
Diversity of the early step of the futalosine pathway.
Arakawa C, Kuratsu M, Furihata K, Hiratsuka T, Itoh N, Seto H, Dairi T. Arakawa C, et al. Antimicrob Agents Chemother. 2011 Feb;55(2):913-6. doi: 10.1128/AAC.01362-10. Epub 2010 Nov 22. Antimicrob Agents Chemother. 2011. PMID: 21098241 Free PMC article.
We recently demonstrated that the futalosine pathway was operating in some bacteria for the biosynthesis of menaquinone and that futalosine was converted into dehypoxanthinyl futalosine (DHFL) by an MqnB of Thermus thermophilus. In this study, we found that a …
We recently demonstrated that the futalosine pathway was operating in some bacteria for the biosynthesis of menaquinone and that f …
Immucillins in Infectious Diseases.
Evans GB, Tyler PC, Schramm VL. Evans GB, et al. ACS Infect Dis. 2018 Feb 9;4(2):107-117. doi: 10.1021/acsinfecdis.7b00172. Epub 2017 Dec 5. ACS Infect Dis. 2018. PMID: 29151351 Free PMC article. Review.
42 results