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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
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1989 5
1991 8
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1994 7
1995 8
1996 19
1997 13
1998 12
1999 14
2000 19
2001 17
2002 21
2003 30
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2005 26
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2007 36
2008 28
2009 33
2010 27
2011 19
2012 34
2013 33
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622 results

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Page 1
Severe congenital neutropenias.
Skokowa J, Dale DC, Touw IP, Zeidler C, Welte K. Skokowa J, et al. Nat Rev Dis Primers. 2017 Jun 8;3:17032. doi: 10.1038/nrdp.2017.32. Nat Rev Dis Primers. 2017. PMID: 28593997 Free PMC article. Review.
The most frequent pathogenic defects are autosomal dominant mutations in ELANE, which encodes neutrophil elastase, and autosomal recessive mutations in HAX1, whose product contributes to the activation of the granulocyte colony-stimulating factor (G-CSF) signalling …
The most frequent pathogenic defects are autosomal dominant mutations in ELANE, which encodes neutrophil elastase, and autosomal recessive m …
G Protein-Coupled Receptors: A Century of Research and Discovery.
Liu S, Anderson PJ, Rajagopal S, Lefkowitz RJ, Rockman HA. Liu S, et al. Circ Res. 2024 Jun 21;135(1):174-197. doi: 10.1161/CIRCRESAHA.124.323067. Epub 2024 Jun 20. Circ Res. 2024. PMID: 38900852 Free PMC article. Review.
GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors, are the largest receptor family in the human genome, with 800 members. ...Sharing a conserved structure comprised of 7 transmembrane alpha-helices, GPCRs couple to heterotrimeric …
GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors, are the largest receptor family in the human gen …
Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling.
Cheng Y, Zhang M, Li C, Su L, Fu L, Wu S, Xu C, Sun B, Chen L. Cheng Y, et al. Nat Commun. 2025 Feb 4;16(1):1332. doi: 10.1038/s41467-025-55970-3. Nat Commun. 2025. PMID: 39905000 Free PMC article.
Here, we confirm that angiogenic factor 1 with a G patch and FHA domain (AGGF1) is elevated in the diabetics and induces retinal angiogenesis. ...Additionally, we discover that sodium-glucose cotransporter 2 inhibitors (SGLT2i) could inhibit the AGGF1 signalling …
Here, we confirm that angiogenic factor 1 with a G patch and FHA domain (AGGF1) is elevated in the diabetics and induces retinal angi …
miR-369-3p ameliorates diabetes-associated atherosclerosis by regulating macrophage succinate-GPR91 signalling.
Rawal S, Randhawa V, Rizvi SHM, Sachan M, Wara AK, Pérez-Cremades D, Weisbrod RM, Hamburg NM, Feinberg MW. Rawal S, et al. Cardiovasc Res. 2024 Nov 25;120(14):1693-1712. doi: 10.1093/cvr/cvae102. Cardiovasc Res. 2024. PMID: 38703377 Free PMC article.
Identifying critical factors to restore metabolic alterations and promote resolution of inflammation remains an unmet goal. MicroRNAs orchestrate multiple signalling events in macrophages, yet their therapeutic potential in diabetes-associated atherosclerosis remain …
Identifying critical factors to restore metabolic alterations and promote resolution of inflammation remains an unmet goal. MicroRNAs orches …
Atypical G(alphai) signal transduction.
Perrault R, Zahradka P. Perrault R, et al. Curr Vasc Pharmacol. 2014 Mar;12(2):258-70. doi: 10.2174/1570161112666140226122512. Curr Vasc Pharmacol. 2014. PMID: 24568155 Review.
G protein signaling is an extremely complex event that is involved in almost every cellular process. ...We then describe a novel concept in G(alphai/o) signaling, namely that the pathways induced by agonist binding circumvent the typical …
G protein signaling is an extremely complex event that is involved in almost every cellular process. ...We then describ …
Platelet signaling-a primer.
Goggs R, Poole AW. Goggs R, et al. J Vet Emerg Crit Care (San Antonio). 2012 Feb;22(1):5-29. doi: 10.1111/j.1476-4431.2011.00704.x. Epub 2012 Feb 3. J Vet Emerg Crit Care (San Antonio). 2012. PMID: 22316389 Review.
OBJECTIVE: To review the receptors and signal transduction pathways involved in platelet plug formation and to highlight links between platelets, leukocytes, endothelium, and the coagulation system. ...Activation of these receptors leads to various important …
OBJECTIVE: To review the receptors and signal transduction pathways involved in platelet plug formation and to highligh …
The metabolic sensor AMPK: Twelve enzymes in one.
Smiles WJ, Ovens AJ, Oakhill JS, Kofler B. Smiles WJ, et al. Mol Metab. 2024 Dec;90:102042. doi: 10.1016/j.molmet.2024.102042. Epub 2024 Oct 2. Mol Metab. 2024. PMID: 39362600 Free PMC article. Review.
Finally, we delve into current debate over whether AMPK can form novel protein complexes (e.g., dimers lacking the alpha-subunit), altogether highlighting opportunities for future and impactful research. ...These differences may explain to some extent why in certain …
Finally, we delve into current debate over whether AMPK can form novel protein complexes (e.g., dimers lacking the alpha-subun …
The Role of G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology.
Xu F, Ma J, Wang X, Wang X, Fang W, Sun J, Li Z, Liu J. Xu F, et al. Biomolecules. 2023 Sep 19;13(9):1410. doi: 10.3390/biom13091410. Biomolecules. 2023. PMID: 37759810 Free PMC article. Review.
Although nuclear estrogen receptors, including estrogen receptor-alpha and estrogen receptor-beta, have been shown to be classical receptors that mediate genomic effects, studies now show that GPER mainly mediates rapid signaling events as well as transcripti …
Although nuclear estrogen receptors, including estrogen receptor-alpha and estrogen receptor-beta, have been shown to be classical re …
Targeting molecular pathways to control immune checkpoint inhibitor toxicities.
Reschke R, Sullivan RJ, Lipson EJ, Enk AH, Gajewski TF, Hassel JC. Reschke R, et al. Trends Immunol. 2025 Jan;46(1):61-73. doi: 10.1016/j.it.2024.11.014. Epub 2024 Dec 27. Trends Immunol. 2025. PMID: 39732529 Free article. Review.
It examines key immune cells, such as T cell subsets and myeloid cells, which are instrumental in irAE pathogenesis, alongside an in-depth analysis of cytokine signaling [interleukin (IL)-6, IL-17, IL-4), interferon gamma (IFN-gamma), IL-1beta, tumor necrosis factor alp …
It examines key immune cells, such as T cell subsets and myeloid cells, which are instrumental in irAE pathogenesis, alongside an in-depth a …
Integrin-dependent signal transduction.
Lafrenie RM, Yamada KM. Lafrenie RM, et al. J Cell Biochem. 1996 Jun 15;61(4):543-53. doi: 10.1002/(sici)1097-4644(19960616)61:4<543::aid-jcb7>3.0.co;2-o. J Cell Biochem. 1996. PMID: 8806077 Review.
In some instances activation of transcription factors and induction of gene expression have also been demonstrated. Components of key signaling pathways involving integrins are beginning to be identified. Some studies have shown that integrins form multi-component c …
In some instances activation of transcription factors and induction of gene expression have also been demonstrated. Components of key sig …
622 results