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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
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1957 1
1958 1
1959 1
1962 2
1963 1
1964 2
1968 1
1969 1
1970 5
1971 32
1972 42
1973 50
1974 63
1975 155
1976 287
1977 384
1978 399
1979 463
1980 678
1981 810
1982 1018
1983 1158
1984 1444
1985 1703
1986 1832
1987 1734
1988 1940
1989 2141
1990 2418
1991 2641
1992 2704
1993 3088
1994 3219
1995 3490
1996 3686
1997 4062
1998 4446
1999 4695
2000 5199
2001 5280
2002 5632
2003 5874
2004 6092
2005 6356
2006 6886
2007 7087
2008 7262
2009 7169
2010 7354
2011 7530
2012 7830
2013 7762
2014 7504
2015 7437
2016 7184
2017 6895
2018 6720
2019 6657
2020 6695
2021 6104
2022 5037
2023 4251
2024 5152
2025 5894
2026 3332

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202,544 results

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Page 1
The Molecular Basis of G Protein-Coupled Receptor Activation.
Weis WI, Kobilka BK. Weis WI, et al. Annu Rev Biochem. 2018 Jun 20;87:897-919. doi: 10.1146/annurev-biochem-060614-033910. Annu Rev Biochem. 2018. PMID: 29925258 Free PMC article. Review.
G protein-coupled receptors (GPCRs) mediate the majority of cellular responses to external stimuli. ...GPCRs can also activate distinct signaling pathways through arrestins. Active states of GPCRs form by small rearrangements of the ligan …
G protein-coupled receptors (GPCRs) mediate the majority of cellular responses to external stimuli. ...GPCRs can …
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL. Yu FX, et al. Cell. 2012 Aug 17;150(4):780-91. doi: 10.1016/j.cell.2012.06.037. Epub 2012 Aug 2. Cell. 2012. PMID: 22863277 Free PMC article.
Here, we report that the Hippo pathway is regulated by G-protein-coupled receptor (GPCR) signaling. Serum-borne lysophosphatidic acid (LPA) and sphingosine 1-phosphophate (S1P) act through G12/13-coupled receptors to inhibit the Hippo pathway ki …
Here, we report that the Hippo pathway is regulated by G-protein-coupled receptor (GPCR) signaling. Serum-borne …
Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk.
Lao-Peregrin C, Xiang G, Kim J, Srivastava I, Fall AB, Gerhard DM, Kohtala P, Kim D, Song M, Garcia-Marcos M, Levitz J, Lee FS. Lao-Peregrin C, et al. Cell Rep. 2024 Jan 23;43(1):113595. doi: 10.1016/j.celrep.2023.113595. Epub 2023 Dec 19. Cell Rep. 2024. PMID: 38117654 Free PMC article.
However, both the molecular mechanisms and the physiological roles of crosstalk between receptors, especially those from different superfamilies, are poorly understood. We find that the receptor tyrosine kinase (RTK) TrkB and the G-protein-coupled r …
However, both the molecular mechanisms and the physiological roles of crosstalk between receptors, especially those from different su …
Mechanisms of adhesion G protein-coupled receptor activation.
Vizurraga A, Adhikari R, Yeung J, Yu M, Tall GG. Vizurraga A, et al. J Biol Chem. 2020 Oct 9;295(41):14065-14083. doi: 10.1074/jbc.REV120.007423. Epub 2020 Aug 6. J Biol Chem. 2020. PMID: 32763969 Free PMC article. Review.
Adhesion G protein-coupled receptors (AGPCRs) are a thirty-three-member subfamily of Class B GPCRs that control a wide array of physiological processes and are implicated in disease. ...Currently, there is no existing structure of an activated A …
Adhesion G protein-coupled receptors (AGPCRs) are a thirty-three-member subfamily of Class B GPCRs that control …
New Insights into Modes of GPCR Activation.
Wang W, Qiao Y, Li Z. Wang W, et al. Trends Pharmacol Sci. 2018 Apr;39(4):367-386. doi: 10.1016/j.tips.2018.01.001. Epub 2018 Jan 31. Trends Pharmacol Sci. 2018. PMID: 29395118 Review.
In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of heterotrimeric G proteins on the membrane and then activate downstream signaling pathways. More recently, GPCRs have been found to couple to different …
In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of heterotrimeric G …
G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.
Szwabowski GL, Griffing M, Mugabe EJ, O'Malley D, Baker LN, Baker DL, Parrill AL. Szwabowski GL, et al. Int J Mol Sci. 2024 Jun 22;25(13):6876. doi: 10.3390/ijms25136876. Int J Mol Sci. 2024. PMID: 38999982 Free PMC article.
G protein-coupled receptor (GPCR) transmembrane protein family members play essential roles in physiology. ...A binary classifier which treated agonists, antagonists, and inverse agonists as active and all other ligands as inactive proved highly …
G protein-coupled receptor (GPCR) transmembrane protein family members play essential roles in physiology. ...A …
G Protein-Coupled Receptor Signaling Through beta-Arrestin-Dependent Mechanisms.
Jean-Charles PY, Kaur S, Shenoy SK. Jean-Charles PY, et al. J Cardiovasc Pharmacol. 2017 Sep;70(3):142-158. doi: 10.1097/FJC.0000000000000482. J Cardiovasc Pharmacol. 2017. PMID: 28328745 Free PMC article. Review.
beta-arrestin1 (or arrestin2) and beta-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic adaptor proteins that were originally discovered for their inhibitory role in G protein-coupled receptor (GPCR) signaling through heterotrimeric G prot …
beta-arrestin1 (or arrestin2) and beta-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic adaptor proteins that were originally d …
G Protein-coupled Receptor Biased Agonism.
Hodavance SY, Gareri C, Torok RD, Rockman HA. Hodavance SY, et al. J Cardiovasc Pharmacol. 2016 Mar;67(3):193-202. doi: 10.1097/FJC.0000000000000356. J Cardiovasc Pharmacol. 2016. PMID: 26751266 Free PMC article. Review.
G protein-coupled receptors are the largest family of targets for current therapeutics. ...Subsequently, the revised concept of biased agonism emerged, where different ligands at the same G protein-coupled receptor selective …
G protein-coupled receptors are the largest family of targets for current therapeutics. ...Subsequently, the rev …
Activation of G-protein-coupled receptor 183 initiates inflammatory pain via macrophage CCL22 secretion.
Qi Z, Zhong W, Jiao B, Chen K, Yang X, Wang L, Zeng W, Huang J, Xie J. Qi Z, et al. Eur J Pharmacol. 2023 Sep 5;954:175872. doi: 10.1016/j.ejphar.2023.175872. Epub 2023 Jun 21. Eur J Pharmacol. 2023. PMID: 37353188
Chronic pain is a major public health problem with limited effective therapeutic options. G-protein-coupled receptors play a significant role in pain modulation; however, whether and how G-protein-coupled receptor 183 partic …
Chronic pain is a major public health problem with limited effective therapeutic options. G-protein-coupled receptor …
Structural basis for lipid-mediated activation of G protein-coupled receptor GPR55.
Claff T, Ebenhoch R, Kley JT, Magarkar A, Nar H, Weichert D. Claff T, et al. Nat Commun. 2025 Feb 25;16(1):1973. doi: 10.1038/s41467-025-57204-y. Nat Commun. 2025. PMID: 40000629 Free PMC article.
GPR55 is an orphan G protein-coupled receptor (GPCR) and represents a promising drug target for cancer, inflammation, and metabolic diseases. The endogenous activation of lipid GPCRs can be solely mediated by membrane components and different li …
GPR55 is an orphan G protein-coupled receptor (GPCR) and represents a promising drug target for cancer, inflamma …
202,544 results
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