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Year Number of Results
1952 1
1953 1
1956 1
1963 1
1970 2
1971 8
1972 22
1973 19
1974 39
1975 53
1976 121
1977 224
1978 309
1979 394
1980 628
1981 790
1982 1051
1983 1185
1984 1453
1985 1641
1986 1765
1987 1706
1988 1928
1989 2116
1990 2216
1991 2403
1992 2524
1993 2731
1994 2822
1995 2850
1996 2855
1997 2923
1998 2966
1999 3135
2000 3133
2001 3053
2002 3151
2003 3075
2004 3236
2005 3066
2006 3106
2007 2970
2008 3122
2009 2981
2010 3048
2011 3017
2012 3043
2013 3186
2014 2956
2015 2893
2016 2733
2017 2595
2018 2481
2019 2509
2020 2556
2021 2312
2022 1845
2023 1649
2024 1866
2025 2241
2026 1147

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107,864 results

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Page 1
The Molecular Basis of G Protein-Coupled Receptor Activation.
Weis WI, Kobilka BK. Weis WI, et al. Annu Rev Biochem. 2018 Jun 20;87:897-919. doi: 10.1146/annurev-biochem-060614-033910. Annu Rev Biochem. 2018. PMID: 29925258 Free PMC article. Review.
G protein-coupled receptors (GPCRs) mediate the majority of cellular responses to external stimuli. ...Active states of GPCRs form by small rearrangements of the ligand-binding, or orthosteric, site that are amplified into larger conformational …
G protein-coupled receptors (GPCRs) mediate the majority of cellular responses to external stimuli. ...Active st …
G protein-coupled receptor pharmacology-The next generation.
Bräuner-Osborne H, Rosenkilde MM, Gether U, Gloriam DE. Bräuner-Osborne H, et al. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6:3-4. doi: 10.1111/bcpt.13291. Epub 2019 Aug 21. Basic Clin Pharmacol Toxicol. 2020. PMID: 31301209 No abstract available.
Melatonin receptor structure and signaling.
Okamoto HH, Cecon E, Nureki O, Rivara S, Jockers R. Okamoto HH, et al. J Pineal Res. 2024 Apr;76(3):e12952. doi: 10.1111/jpi.12952. J Pineal Res. 2024. PMID: 38587234 Review.
Melatonin (5-methoxy-N-acetyltryptamine) binds with high affinity and specificity to membrane receptors. Several receptor subtypes exist in different species, of which the mammalian MT(1) and MT(2) receptors are the best-characterized. They are members of the …
Melatonin (5-methoxy-N-acetyltryptamine) binds with high affinity and specificity to membrane receptors. Several receptor subt …
Rational design of biased G protein-coupled receptor agonists.
Gurevich VV. Gurevich VV. Mol Pharmacol. 2025 Dec;107(12):100089. doi: 10.1016/j.molpha.2025.100089. Epub 2025 Nov 19. Mol Pharmacol. 2025. PMID: 41349424 Free article. Review.
Activation of most G protein-coupled receptors (GPCRs) initiates several branches of signaling. The consequences of some of these can be therapeutically beneficial, whereas others may cause unwanted side effects. ...SIGNIFICANCE STATEMENT: Because arre …
Activation of most G protein-coupled receptors (GPCRs) initiates several branches of signaling. The consequences …
Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor.
Miller LJ, Dong M, Harikumar KG. Miller LJ, et al. Br J Pharmacol. 2012 May;166(1):18-26. doi: 10.1111/j.1476-5381.2011.01463.x. Br J Pharmacol. 2012. PMID: 21542831 Free PMC article. Review.
The secretin receptor is a prototypic member of family B G protein-coupled receptors that binds and responds to a linear 27-residue peptide natural ligand. ...The amino terminus of secretin is directed toward the core helical bundle domain of th …
The secretin receptor is a prototypic member of family B G protein-coupled receptors that binds and respo …
GPCR activation and GRK2 assembly by a biased intracellular agonist.
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE. Duan J, et al. Nature. 2023 Aug;620(7974):676-681. doi: 10.1038/s41586-023-06395-9. Epub 2023 Aug 2. Nature. 2023. PMID: 37532940
Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) desensitizes G-protein signalling and promotes arrestin signalling, which is also modulated by biased ligands(1-6). ...The binding mode of SBI-553 is compatible with a …
Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) desensitizes G-protein signalling …
Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells.
Wager-Miller J, Mackie K. Wager-Miller J, et al. Methods Mol Biol. 2023;2576:395-406. doi: 10.1007/978-1-0716-2728-0_33. Methods Mol Biol. 2023. PMID: 36152205
Measuring the functional behavior of G protein-coupled receptors (GPCRs) has been a major focus of academic and pharmaceutical research for many decades. These efforts have led to the development of many assays to measure the downstream effects of liga …
Measuring the functional behavior of G protein-coupled receptors (GPCRs) has been a major focus of academic and …
Characterization of the GTPgammaS release function of a G protein-coupled receptor.
Bohn LM, Stahl EL. Bohn LM, et al. Nat Commun. 2025 Dec 17;16(1):11193. doi: 10.1038/s41467-025-66516-y. Nat Commun. 2025. PMID: 41407695 Free PMC article.
G protein-coupled receptor (GPCR) signaling is one of the most ubiquitous and sensitive forms of cell surface reception. ...Further, we show that agonists have the potential to preferentially stimulate GTP binding or GTP release. This release se …
G protein-coupled receptor (GPCR) signaling is one of the most ubiquitous and sensitive forms of cell surface re …
Activation of G protein-coupled receptor 39 alleviates neuropathic pain and chronic inflammation.
Cheng F, Yan F, Yang A, Liu J, Ma J. Cheng F, et al. J Biochem Mol Toxicol. 2024 Jan;38(1):e23545. doi: 10.1002/jbt.23545. Epub 2023 Oct 16. J Biochem Mol Toxicol. 2024. PMID: 37842769
It is claimed that activated microglia-mediated neuroinflammation participates in the development of NP, which is regulated by p38 mitogen-activated protein kinase (MAPK)/nuclear factor-kappaappa B (NF-kappaB) p65 signaling. G protein-coupled receptor …
It is claimed that activated microglia-mediated neuroinflammation participates in the development of NP, which is regulated by p38 mitogen-a …
107,864 results
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