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Modelling acute antibody-mediated rejection of human kidney transplants using ex-vivo warm machine perfusion.
Chandak P, Phillips BL, Bennett D, Uwechue R, Kessaris N, Shaw O, Maggs T, Woodford L, Veniard D, Perera R, Parmar K, Hunt BJ, Callaghan C, Dorling A, Mamode N. Chandak P, et al. EBioMedicine. 2022 Dec;86:104365. doi: 10.1016/j.ebiom.2022.104365. Epub 2022 Nov 22. EBioMedicine. 2022. PMID: 36427468 Free PMC article.
For the ABOi model, high titre FFP of the relevant blood group antibody was added. Renal blood flow index (RBFi, mL/min/100 g), C3 desArg, prothrombin fragments 1 + 2 and histology were determined. Our endpoints included haemodynamic changes, thrombosis, and biopsy …
For the ABOi model, high titre FFP of the relevant blood group antibody was added. Renal blood flow index (RBFi, mL/min/100 g), C3 …
Recommendations for Use of Meningococcal Conjugate Vaccines in HIV-Infected Persons - Advisory Committee on Immunization Practices, 2016.
MacNeil JR, Rubin LG, Patton M, Ortega-Sanchez IR, Martin SW. MacNeil JR, et al. MMWR Morb Mortal Wkly Rep. 2016 Nov 4;65(43):1189-1194. doi: 10.15585/mmwr.mm6543a3. MMWR Morb Mortal Wkly Rep. 2016. PMID: 27811836 Free article.
ACIP has previously recommended routine vaccination of persons aged 2 months who have certain medical conditions that increase risk for meningococcal disease (1), including persons who have persistent (e.g., genetic) deficiencies in the complement pathway (e.g., C3, …
ACIP has previously recommended routine vaccination of persons aged 2 months who have certain medical conditions that increase risk for meni …
Updated recommendation from the Advisory Committee on Immunization Practices (ACIP) for revaccination of persons at prolonged increased risk for meningococcal disease.
Centers for Disease Control and Prevention (CDC). Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep. 2009 Sep 25;58(37):1042-3. MMWR Morb Mortal Wkly Rep. 2009. PMID: 19779400 Free article.
Persons at prolonged increased risk for meningococcal disease include 1) persons with increased susceptibility such as persistent complement component deficiencies (e.g., C3, properdin, Factor D, and late complement component deficiencies), 2) persons with anatomic …
Persons at prolonged increased risk for meningococcal disease include 1) persons with increased susceptibility such as persistent complement …
Controlling the complement system in inflammation.
Kirschfink M. Kirschfink M. Immunopharmacology. 1997 Dec;38(1-2):51-62. doi: 10.1016/s0162-3109(97)00057-x. Immunopharmacology. 1997. PMID: 9476114 Review.
Attempts to efficiently inhibit complement include the application of endogenous soluble complement inhibitors (C1-inhibitor, recombinant soluble complement receptor 1- rsCR1), the administration of antibodies, either blocking key proteins of the cascade reaction (e.g. …
Attempts to efficiently inhibit complement include the application of endogenous soluble complement inhibitors (C1-inhibitor, recombinant so …