Modelling acute antibody-mediated rejection of human kidney transplants using ex-vivo warm machine perfusion.
Chandak P, Phillips BL, Bennett D, Uwechue R, Kessaris N, Shaw O, Maggs T, Woodford L, Veniard D, Perera R, Parmar K, Hunt BJ, Callaghan C, Dorling A, Mamode N.
Chandak P, et al.
EBioMedicine. 2022 Dec;86:104365. doi: 10.1016/j.ebiom.2022.104365. Epub 2022 Nov 22.
EBioMedicine. 2022.
PMID: 36427468
Free PMC article.
Here, using 12 human kidneys and ex-vivo normothermic machine perfusion, we demonstrate phenotypes of AMR after addition of antibodies against either human HLA class I or blood group antigens (A, B), thus modelling clinical AMR that can follow HLA incompatible (HLAi) or bl …
Here, using 12 human kidneys and ex-vivo normothermic machine perfusion, we demonstrate phenotypes of AMR after addition of antibodies again …