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Page 1
DNA-RNA hybrids: the risks of DNA breakage during transcription.
Aguilera A, Gómez-González B. Aguilera A, et al. Nat Struct Mol Biol. 2017 May 4;24(5):439-443. doi: 10.1038/nsmb.3395. Nat Struct Mol Biol. 2017. PMID: 28471430
Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex.
Gómez-González B, Aguilera A. Gómez-González B, et al. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8409-14. doi: 10.1073/pnas.0702836104. Epub 2007 May 8. Proc Natl Acad Sci U S A. 2007. PMID: 17488823 Free PMC article.
Genome instability: a mechanistic view of its causes and consequences.
Aguilera A, Gómez-González B. Aguilera A, et al. Nat Rev Genet. 2008 Mar;9(3):204-17. doi: 10.1038/nrg2268. Nat Rev Genet. 2008. PMID: 18227811 Review.
The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.
González-Aguilera C, Tous C, Gómez-González B, Huertas P, Luna R, Aguilera A. González-Aguilera C, et al. Mol Biol Cell. 2008 Oct;19(10):4310-8. doi: 10.1091/mbc.e08-04-0355. Epub 2008 Jul 30. Mol Biol Cell. 2008. PMID: 18667528 Free PMC article.
DNA repair in mammalian cells: DNA double-strand break repair: how to fix a broken relationship.
Pardo B, Gómez-González B, Aguilera A. Pardo B, et al. Cell Mol Life Sci. 2009 Mar;66(6):1039-56. doi: 10.1007/s00018-009-8740-3. Cell Mol Life Sci. 2009. PMID: 19153654 Review.
R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX.
Gómez-González B, Aguilera A. Gómez-González B, et al. Nucleic Acids Res. 2009 Jul;37(13):4315-21. doi: 10.1093/nar/gkp385. Epub 2009 May 18. Nucleic Acids Res. 2009. PMID: 19451165 Free PMC article.
The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants.
Gómez-González B, Felipe-Abrio I, Aguilera A. Gómez-González B, et al. Mol Cell Biol. 2009 Oct;29(19):5203-13. doi: 10.1128/MCB.00402-09. Epub 2009 Aug 3. Mol Cell Biol. 2009. PMID: 19651896 Free PMC article.
Chromosomal translocations caused by either pol32-dependent or pol32-independent triparental break-induced replication.
Ruiz JF, Gómez-González B, Aguilera A. Ruiz JF, et al. Mol Cell Biol. 2009 Oct;29(20):5441-54. doi: 10.1128/MCB.00256-09. Epub 2009 Aug 3. Mol Cell Biol. 2009. PMID: 19651902 Free PMC article.
Yeast Sen1 helicase protects the genome from transcription-associated instability.
Mischo HE, Gómez-González B, Grzechnik P, Rondón AG, Wei W, Steinmetz L, Aguilera A, Proudfoot NJ. Mischo HE, et al. Mol Cell. 2011 Jan 7;41(1):21-32. doi: 10.1016/j.molcel.2010.12.007. Mol Cell. 2011. PMID: 21211720 Free PMC article.
AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.
Ruiz JF, Gómez-González B, Aguilera A. Ruiz JF, et al. PLoS Genet. 2011 Feb;7(2):e1002009. doi: 10.1371/journal.pgen.1002009. Epub 2011 Feb 24. PLoS Genet. 2011. PMID: 21383964 Free PMC article.
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